Ariadne Genomics Inc. Trichothiodystrophy Syndromes Cockayne Syndrome Xeroderma Pigmentosum Ercc2 ---> Trichothiodystrophy Syndromes Ercc2 ---> Xeroderma Pigmentosum Ercc2 Xpc ---> Xeroderma Pigmentosum Xpc Ddb1 ---> Xeroderma Pigmentosum Ddb1 Ercc3 ---> Trichothiodystrophy Syndromes Ercc4 ---> Xeroderma Pigmentosum Ercc5 ---> Xeroderma Pigmentosum Ercc5 Xpa ---> Xeroderma Pigmentosum Xpa Ercc4 Ercc3 ---> Xeroderma Pigmentosum Ercc3 Ercc8 ---> Cockayne Syndrome Ercc8 Ercc6 ---> Cockayne Syndrome Ercc6 Ddb2 pold complex Rpa complex Hmgn1 Gtf2h1 pole complex stalled polrII complex pole complex ---- Rpa complex pold complex ---- Rpa complex Polk ---- Rpa complex Xrcc1 Lig1 Lig3 ---- Xrcc1 Lig3 TFIIH complex Xab2 Pcna ---- Rfc complex Pcna ---- pole complex Cetn2 Rad23b Pcna ---- pold complex Pcna Polk Pcna ---- Polk Ercc1 Gtf2h2 Rfc complex chromatin modification/remodeling pathway