| URN | urn:agi-llid:1159 |
|---|---|
| Total Entities | 0 |
| Connectivity | 170 |
| Name | CKMT1B |
| Description | creatine kinase, mitochondrial 1B |
| Notes | Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008] |
| Pathway | cardiolipin metabolic pathway |
|---|
| Group | Biofluids assayable substances |
|---|
| LocusLink ID | 1159 |
|---|
| Cell Localization | Mitochondrion inner membrane |
|---|
| Alias | CKMT |
|---|---|
| CKMT1 | |
| UMTCK | |
| creatine kinase U-type, mitochondrial | |
| U-MtCK | |
| mia-CK | |
| ubiquitous mitochondrial creatine kinase | |
| acidic-type mitochondrial creatine kinase | |
| creatine kinase, mitochondrial 1 (ubiquitous) | |
| CKMT1B | |
| Ckmt I | |
| ScCKmits | |
| Creatine kinase, mitochondrial | |
| mitochondrion creatine kinase | |
| creatine kinase mt mt | |
| creatine kinase mi mi | |
| creatine kinase isoenzyme mt mt | |
| creatine kinase isoenzyme mi mi | |
| UbCKmits | |
| U- MtCK | |
| ScCKmit | |
| OTTMUSP00000016246 | |
| OTTMUSP00000016245 | |
| Creatine kinase, ubiquitous mitochondrial | |
| Creatine kinase, mitochondrial 1 | |
| UbCKmit | |
| Creatine kinase, mitochondrial I | |
| OTTHUMP00000200125 | |
| mi-CK | |
| OTTHUMP00000066275 | |
| mitochondrial Creatine kinase 1 | |
| mitochondrial creatine kinase 1 (ubiquitous) | |
| mitochondrial Creatine kinase I | |
| Mt-CK | |
| mitochondrial Creatine kinase | |
| creatine kinase, mitochondrial 1B |
| OMIM ID | 123290 |
|---|
| Hugo ID | 1995 |
|---|---|
| 31736 |
| Human chromosome position | 15q15 |
|---|
| Swiss-Prot Accession | P12532 |
|---|---|
| B4DIT8 | |
| B7ZA09 | |
| Q0VAM3 | |
| Q32NF6 | |
| Q53FC4 |
| PIR ID | A31431 |
|---|
| Unigene ID | Hs.741420 |
|---|
| KEGG ID | hsa:1159 |
|---|---|
| hsa:548596 |
| Swiss-Prot ID | KCRU_HUMAN |
|---|
| EC Number | 2.7.3.2 |
|---|
| Ensembl ID | ENSG00000237289 |
|---|---|
| ENSP00000300283 | |
| ENST00000300283 | |
| ENSP00000413255 | |
| ENST00000441322 |
| Organism | Homo sapiens |
|---|
| RGD ID | 1345536 |
|---|
| MedScan ID | 1159 |
|---|