| URN | urn:agi-llid:4833 |
|---|---|
| Total Entities | 0 |
| Connectivity | 52 |
| Name | Nme4 |
| Description | NME/NM23 nucleoside diphosphate kinase 4 |
| Notes | The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008] |
| GO Molecular Function | nucleoside diphosphate kinase activity |
|---|---|
| transferase activity | |
| kinase activity | |
| protein complex binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding |
| GO Cellular Component | mitochondrial inner membrane |
|---|---|
| mitochondrial intermembrane space | |
| mitochondrion |
| GO Biological Process | small molecule metabolic process |
|---|---|
| nucleoside diphosphate phosphorylation | |
| GTP biosynthetic process | |
| CTP biosynthetic process | |
| UTP biosynthetic process | |
| nucleobase-containing small molecule metabolic process | |
| nucleoside metabolic process | |
| nucleobase-containing small molecule interconversion | |
| nucleotide metabolic process | |
| phosphorylation |
| Pathway | cardiolipin metabolic pathway |
|---|
| Group | Purine metabolism |
|---|---|
| Pyrimidine metabolism | |
| small molecule metabolic process | |
| nucleoside diphosphate phosphorylation | |
| nucleoside diphosphate kinase activity | |
| GTP biosynthetic process | |
| CTP biosynthetic process | |
| UTP biosynthetic process | |
| nucleobase-containing small molecule metabolic process | |
| nucleoside metabolic process | |
| nucleobase-containing small molecule interconversion | |
| nucleotide metabolic process | |
| transferase activity | |
| kinase activity | |
| phosphorylation | |
| protein complex binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| mitochondrial inner membrane | |
| mitochondrial intermembrane space | |
| mitochondrion |
| LocusLink ID | 4833 |
|---|---|
| 56520 | |
| 685679 |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion intermembrane space |
| GO ID | 0005524 |
|---|---|
| 0046872 | |
| 0004550 | |
| 0006241 | |
| 0006183 | |
| 0006228 | |
| 0015949 | |
| 0055086 | |
| 0009116 | |
| 0044281 | |
| 0005743 | |
| 0005758 | |
| 0005739 | |
| 0016301 | |
| 0000166 | |
| 0032403 | |
| 0016740 | |
| 0006165 | |
| 0009117 | |
| 0016310 |
| Alias | NDPK-D |
|---|---|
| NM23H4 | |
| nm23-H4 | |
| Z97634.4-011 | |
| nucleoside diphosphate kinase, mitochondrial | |
| NDK | |
| NDPKD | |
| NDP kinase D | |
| NDP kinase, mitochondrial | |
| nucleoside diphosphate kinase D | |
| non-metastatic cells 4, protein expressed in | |
| Nm23M4 | |
| NM23-M4 | |
| 2610027N22Rik | |
| 2810024O08Rik | |
| 5730493H09Rik | |
| expressed in non-metastatic cells 4, protein | |
| nucleoside diphosphate kinase 4 | |
| NM23D | |
| nucleoside diphosphate kinase IV | |
| non-metastatic cells 4, protein expressed in (nucleoside-diphosphate kinase | |
| OTTHUMP00000194917 | |
| nucleoside diphosphate kinase (nm23-M4) | |
| OTTHUMP00000194919 | |
| OTTHUMP00000206530 | |
| Z97634.4 | |
| RIKEN cDNA 2610027N22 gene | |
| RIKEN cDNA 2810024O08 gene | |
| NME/NM23 nucleoside diphosphate kinase 4 | |
| mitochondrial NDP kinase | |
| RIKEN cDNA 5730493H09 gene | |
| Nme4 | |
| 2810024O08 | |
| 5730493H09 | |
| LOC682382 | |
| NM23-M4)(nucleoside diphosphate kinase | |
| mitochondrial Nucleoside diphosphate kinase | |
| 2610027N22 |
| Mouse chromosome position | 17 |
|---|
| OMIM ID | 601818 |
|---|
| Rat chromosome position | 10q12 |
|---|
| Hugo ID | 7852 |
|---|
| Human chromosome position | 16p13.3 |
|---|
| Swiss-Prot Accession | O00746 |
|---|---|
| A2IDD0 | |
| Q9WV84 | |
| D3ZMT9 | |
| Q5U0M9 |
| Unigene ID | Hs.9235 |
|---|---|
| Mm.41787 | |
| Rn.145946 |
| KEGG ID | hsa:4833 |
|---|---|
| mmu:56520 | |
| rno:685679 |
| Swiss-Prot ID | NDKM_HUMAN |
|---|---|
| NDKM_MOUSE |
| EC Number | 2.7.4.6 |
|---|
| Ensembl ID | ENSG00000103202 |
|---|---|
| ENSP00000219479 | |
| ENST00000219479 | |
| ENSP00000380834 | |
| ENST00000397722 | |
| ENSMUSG00000024177 | |
| ENSMUSP00000025007 | |
| ENSMUST00000025007 | |
| ENSRNOG00000049152 | |
| ENSRNOP00000027593 | |
| ENSRNOT00000027593 |
| Homologene ID | 3673 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1931148 |
|---|
| RGD ID | 1591334 |
|---|
| MedScan ID | 4833 |
|---|