Elsevier Inc. cardiolipin --+> metabolite exchange ATP synthase (complex V) Ckmt1 ATP/ADP exchange ATP biosynthetic pathway respiratory complex IV respiratory complex III respiratory complex I phosphatidylglycerol ---> cardiolipin phosphatidic acid ---> CDP-diacylglycerol cytidine triphosphate ---> CDP-diacylglycerol CDP-diacylglycerol cardiolipin ---- CKMT1B cardiolipin ---> translocated cardiolipin CKMT1B ---- translocated cardiolipin Plscr3 ---- translocated cardiolipin Ckmt1 ---- translocated cardiolipin Nme4 ---- translocated cardiolipin cardiolipin ---- Nme4 CDP-diacylglycerol ---> phosphatidylglycerophosphate phosphatidylglycerophosphate ---> phosphatidylglycerol sustained mitochondrial injury translocated cardiolipin peroxidized cardiolipin Tamm41 Pgs1 Ptpmt1 Crls1 Taz CKMT1B Nme4 Plscr3 Cycs ---- translocated cardiolipin Cycs ---> peroxidized cardiolipin Cycs --+> intrinsic apoptotic pathway peroxidized cardiolipin --+> intrinsic apoptotic pathway phosphatidylglycerophosphate phosphatidylglycerol cytidine triphosphate phosphatidic acid mitochondrial autophagy pathway intrinsic apoptotic pathway mitochondrial injury Cycs cardiolipin metabolite exchange electron transport chain pathway cardiolipin ---- Ckmt1 cardiolipin --+> ATP biosynthetic pathway cardiolipin --+> electron transport chain pathway translocated cardiolipin --+> mitochondrial autophagy pathway Taz ---> cardiolipin