Elsevier Inc. arginine lysine chromatin remodeling pathway DNA modification pathway phosphoSTY methylarginine ubiquitinlysine methyllysine acetyllysine histone chaperones Kdeubiquitinases ---> ubiquitinlysine COMPASS complexes ---> lysine PRC2 complex ---> lysine gene expression histone octamer Rme-readers P-readers Kdeubiquitinases Kdemethylases Kme-readers Kac-readers Kdeacetylases Kacetylases ---> gene expression P-readers ---- phosphoSTY Kacetylases ---> lysine Kacetylases methylarginine ---- Rme-readers PRC1 complex ---> lysine acetyllysine ---- Kac-readers Kme-readers ---- methyllysine histone chaperones ---- histone octamer histone chaperones ---- PTM histone octamer Kdeacetylases ---> acetyllysine Kdemethylases ---> methyllysine Kme-readers ---> gene expression Kac-readers ---> gene expression Rmethylases Rmethylases ---> arginine unmodified-Kreaders lncRNAs, chromatin modification ---> gene expression lncRNAs, chromatin modification PTM histone octamer Kmehylases Kmehylases ---> lysine lysine ---- unmodified-Kreaders COMPASS complexes PRC1 complex PRC2 complex PRC1 complex ---| gene expression COMPASS complexes --+> gene expression PRC2 complex ---| gene expression Kdeubiquitinases --+> gene expression Kdeacetylases ---| gene expression