| URN | urn:agi-llid:3395 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1118 |
| Name | Ido1 |
| Description | indoleamine 2,3-dioxygenase 1 |
| Notes | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| dioxygenase activity | |
| tryptophan 2,3-dioxygenase activity | |
| indoleamine 2,3-dioxygenase activity | |
| electron carrier activity | |
| oxygen binding | |
| amino acid binding | |
| heme binding | |
| metal ion binding |
| GO Cellular Component | smooth muscle contractile fiber |
|---|---|
| cytoplasm | |
| cytosol | |
| stereocilium bundle |
| GO Biological Process | female pregnancy |
|---|---|
| positive regulation of T cell tolerance induction | |
| positive regulation of type 2 immune response | |
| negative regulation of T cell proliferation | |
| negative regulation of activated T cell proliferation | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| kynurenic acid biosynthetic process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| multicellular organismal response to stress | |
| positive regulation of interleukin-12 production | |
| cytokine production involved in inflammatory response | |
| negative regulation of interleukin-10 production | |
| positive regulation of apoptotic process | |
| negative regulation of T cell apoptotic process | |
| behavior | |
| response to lipopolysaccharide | |
| defense response | |
| inflammatory response | |
| positive regulation of chronic inflammatory response | |
| swimming behavior | |
| cellular nitrogen compound metabolic process |
| Pathway | Proteins Involved in Pathogenesis of Diffuse Large-B-cell Lymphoma |
|---|---|
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 1 | |
| Proteins Involved in Pathogenesis of HIV Type 1 Infection | |
| Proteins Involved in Pathogenesis of Cataract | |
| CD40LG/STAT Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| kynurenine metabolic pathway |
| Group | Aromatic amino acid metabolism |
|---|---|
| female pregnancy | |
| positive regulation of T cell tolerance induction | |
| positive regulation of type 2 immune response | |
| negative regulation of T cell proliferation | |
| negative regulation of activated T cell proliferation | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| kynurenic acid biosynthetic process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| oxidoreductase activity | |
| dioxygenase activity | |
| tryptophan 2,3-dioxygenase activity | |
| indoleamine 2,3-dioxygenase activity | |
| multicellular organismal response to stress | |
| positive regulation of interleukin-12 production | |
| cytokine production involved in inflammatory response | |
| negative regulation of interleukin-10 production | |
| positive regulation of apoptotic process | |
| negative regulation of T cell apoptotic process | |
| behavior | |
| response to lipopolysaccharide | |
| defense response | |
| inflammatory response | |
| positive regulation of chronic inflammatory response | |
| swimming behavior | |
| cellular nitrogen compound metabolic process | |
| electron carrier activity | |
| oxygen binding | |
| amino acid binding | |
| heme binding | |
| metal ion binding | |
| smooth muscle contractile fiber | |
| cytoplasm | |
| cytosol | |
| stereocilium bundle | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 3395 |
|---|---|
| 3620 | |
| 15930 | |
| 66029 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0033754 | |
| 0046872 | |
| 0004833 | |
| 0007610 | |
| 0034641 | |
| 0002534 | |
| 0007565 | |
| 0034276 | |
| 0033555 | |
| 0070233 | |
| 0046007 | |
| 0032693 | |
| 0002666 | |
| 0043065 | |
| 0002678 | |
| 0032735 | |
| 0002830 | |
| 0032496 | |
| 0044281 | |
| 0006569 | |
| 0019441 | |
| 0005829 | |
| 0030485 | |
| 0032421 | |
| 0016597 | |
| 0051213 | |
| 0016491 | |
| 0019825 | |
| 0006952 | |
| 0006954 | |
| 0042130 | |
| 0055114 | |
| 0036269 | |
| 0005737 |
| Alias | IDO |
|---|---|
| INDO | |
| IDO-1 | |
| indoleamine 2,3-dioxygenase 1 | |
| indole 2,3-dioxygenase | |
| indolamine 2,3 dioxygenase | |
| indoleamine-pyrrole 2,3-dioxygenase | |
| indoleamine-pyrrole 2,3 dioxygenase | |
| indoleamine 23-dioxygenase | |
| indoleamine 2,3 oxygenase | |
| indolamine dioxygenase | |
| OTTMUSP00000022552 | |
| indolylamine 2,3 dioxygenase | |
| MGC31194 | |
| indoleamine dioxygenase | |
| Indoleamine 2,3-dioxygenase | |
| IDO1 | |
| AI265623 | |
| OTTMUSP00000022551 |
| Mouse chromosome position | 8 |
|---|
| OMIM ID | 147435 |
|---|
| Rat chromosome position | 16q12.5 |
|---|
| Hugo ID | 6059 |
|---|
| Human chromosome position | 8p12-p11 |
|---|
| Swiss-Prot Accession | P14902 |
|---|---|
| P28776 | |
| Q9ERD9 | |
| Q540B4 |
| PIR ID | JH0492 |
|---|---|
| PC1161 |
| Unigene ID | Hs.840 |
|---|---|
| Mm.392 | |
| Rn.64513 |
| KEGG ID | hsa:3620 |
|---|---|
| mmu:15930 | |
| rno:66029 |
| Swiss-Prot ID | I23O1_MOUSE |
|---|---|
| I23O1_RAT | |
| I23O1_HUMAN |
| EC Number | 1.13.11.52 |
|---|
| Ensembl ID | ENSMUSG00000031551 |
|---|---|
| ENSMUSP00000033956 | |
| ENSMUST00000033956 | |
| ENSMUSP00000106295 | |
| ENSMUST00000110667 | |
| ENSRNOG00000031189 | |
| ENSRNOP00000050320 | |
| ENSRNOT00000051363 |
| Homologene ID | 48082 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 96416 |
|---|
| RGD ID | 619989 |
|---|
| MedScan ID | 3395 |
|---|