| URN | urn:agi-llid:8564 |
|---|---|
| Total Entities | 0 |
| Connectivity | 91 |
| Name | Kmo |
| Description | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| Notes | This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| monooxygenase activity | |
| kynurenine 3-monooxygenase activity | |
| NAD(P)H oxidase activity | |
| flavin adenine dinucleotide binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| mitochondrial outer membrane | |
| mitochondrial inner membrane | |
| cytosol | |
| mitochondrion |
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| quinolinate biosynthetic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| kynurenine metabolic process | |
| NAD metabolic process | |
| response to salt stress | |
| cellular nitrogen compound metabolic process |
| Pathway | kynurenine metabolic pathway |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| metabolic process | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| quinolinate biosynthetic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| oxidoreductase activity | |
| monooxygenase activity | |
| kynurenine 3-monooxygenase activity | |
| NAD(P)H oxidase activity | |
| kynurenine metabolic process | |
| NAD metabolic process | |
| response to salt stress | |
| cellular nitrogen compound metabolic process | |
| flavin adenine dinucleotide binding | |
| membrane | |
| integral component of membrane | |
| mitochondrial outer membrane | |
| mitochondrial inner membrane | |
| cytosol | |
| mitochondrion |
| LocusLink ID | 8564 |
|---|---|
| 98256 | |
| 59113 |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion outer membrane |
| GO ID | 0016174 |
|---|---|
| 0050660 | |
| 0004502 | |
| 0009435 | |
| 0034641 | |
| 0070189 | |
| 0019805 | |
| 0009651 | |
| 0044281 | |
| 0006569 | |
| 0019441 | |
| 0005829 | |
| 0016021 | |
| 0005743 | |
| 0005741 | |
| 0004497 | |
| 0016491 | |
| 0019674 | |
| 0008152 | |
| 0055114 | |
| 0019363 | |
| 0016020 | |
| 0005739 |
| Alias | dJ317G22.1 |
|---|---|
| RP1-317G22.1 | |
| kynurenine 3-monooxygenase | |
| kynurenine 3-hydroxylase | |
| AI046660 | |
| L-kynurenine-3-hydroxylase | |
| OTTHUMP00000037618 | |
| OTTMUSP00000031091 | |
| OTTHUMP00000037619 | |
| LOC128134 | |
| L-kynurenine-3-hydroxylases | |
| OTTHUMP00000044540 | |
| kynurenine hydroxylase | |
| kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | |
| kynurenine hydroxylases |
| Mouse chromosome position | 1 |
|---|
| OMIM ID | 603538 |
|---|
| Rat chromosome position | 13q25 |
|---|
| Hugo ID | 6381 |
|---|
| Human chromosome position | 1q42-q44 |
|---|
| Swiss-Prot Accession | A8K693 |
|---|---|
| O15229 | |
| Q91WN4 | |
| O88867 | |
| A2A2U8 | |
| A2A2U9 | |
| A2A2V0 | |
| Q5SY07 | |
| Q5SY08 | |
| Q5SY09 |
| Unigene ID | Hs.731056 |
|---|---|
| Hs.744065 | |
| Mm.27217 | |
| Rn.35029 |
| KEGG ID | hsa:8564 |
|---|---|
| mmu:98256 | |
| rno:59113 |
| Swiss-Prot ID | KMO_RAT |
|---|---|
| KMO_HUMAN | |
| KMO_MOUSE |
| EC Number | 1.14.13.9 |
|---|
| Ensembl ID | ENSG00000117009 |
|---|---|
| ENSP00000355517 | |
| ENST00000366559 | |
| ENSP00000355516 | |
| ENST00000366558 | |
| ENSMUSG00000039783 | |
| ENSMUSP00000038914 | |
| ENSMUST00000040250 |
| Homologene ID | 2729 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2138151 |
|---|
| RGD ID | 620610 |
|---|
| MedScan ID | 8564 |
|---|