| URN | urn:agi-llid:6999 |
|---|---|
| Total Entities | 0 |
| Connectivity | 538 |
| Name | Tdo2 |
| Description | tryptophan 2,3-dioxygenase |
| Notes | This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| dioxygenase activity | |
| tryptophan 2,3-dioxygenase activity | |
| oxygen binding | |
| amino acid binding | |
| heme binding | |
| metal ion binding |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| tryptophan catabolic process to acetyl-CoA | |
| tryptophan metabolic process | |
| cellular nitrogen compound metabolic process |
| Pathway | Proteins Involved in Pathogenesis of Pulmonary Hypertension |
|---|---|
| kynurenine metabolic pathway |
| Group | Aromatic amino acid metabolism |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| tryptophan catabolic process to acetyl-CoA | |
| oxidoreductase activity | |
| dioxygenase activity | |
| tryptophan 2,3-dioxygenase activity | |
| tryptophan metabolic process | |
| cellular nitrogen compound metabolic process | |
| oxygen binding | |
| amino acid binding | |
| heme binding | |
| metal ion binding | |
| cytosol | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 6999 |
|---|---|
| 56720 | |
| 64206 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016597 |
|---|---|
| 0020037 | |
| 0046872 | |
| 0019825 | |
| 0004833 | |
| 0034641 | |
| 0044281 | |
| 0006569 | |
| 0019442 | |
| 0019441 | |
| 0005829 | |
| 0051213 | |
| 0016491 | |
| 0055114 | |
| 0006568 |
| Alias | TO |
|---|---|
| TDO | |
| TPH2 | |
| TRPO | |
| tryptophan 2,3-dioxygenase | |
| tryptophanase | |
| tryptophan oxygenase | |
| tryptophan pyrrolase | |
| tryptamin 2,3-dioxygenase | |
| chky | |
| AA407491 | |
| tdo variant1 | |
| tdo variant2 | |
| tryptophan-2,3-dioxygenase | |
| tryptophan-23-dioxygenase | |
| tryptophan 2,3-dioxygenase A | |
| tryptophanases | |
| tryptamine 2,3-dioxygenases | |
| tryptophan peroxidase | |
| tryptophan peroxidases | |
| tryptamine 2,3-dioxygenase | |
| L-tryptophan pyrrolase | |
| indolamine 2,3-dioxygenases | |
| L-tryptophan pyrrolases | |
| OTTMUSP00000026825 | |
| TDO2 | |
| indolamine 2,3-dioxygenase |
| Mouse chromosome position | 3 |
|---|
| OMIM ID | 191070 |
|---|
| Rat chromosome position | 2q33 |
|---|
| Hugo ID | 11708 |
|---|
| Human chromosome position | 4q31-q32 |
|---|
| Swiss-Prot Accession | P48775 |
|---|---|
| P48776 | |
| Q8VCW3 | |
| P21643 | |
| A8K053 | |
| Q5EBC2 | |
| Q6LBW3 |
| PIR ID | G02022 |
|---|---|
| A35484 |
| Unigene ID | Hs.183671 |
|---|---|
| Hs.593955 | |
| Mm.258622 | |
| Rn.1029 |
| KEGG ID | hsa:6999 |
|---|---|
| mmu:56720 | |
| rno:64206 |
| Swiss-Prot ID | T23O_HUMAN |
|---|---|
| T23O_MOUSE | |
| T23O_RAT |
| EC Number | 1.13.11.11 |
|---|
| Ensembl ID | ENSG00000151790 |
|---|---|
| ENSP00000444788 | |
| ENST00000536354 | |
| ENSRNOG00000011612 | |
| ENSRNOP00000015732 | |
| ENSRNOT00000015732 |
| Homologene ID | 4132 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1928486 |
|---|
| RGD ID | 68370 |
|---|
| MedScan ID | 6999 |
|---|