| URN | urn:agi-llid:130013 |
|---|---|
| Total Entities | 0 |
| Connectivity | 46 |
| Name | Acmsd |
| Description | aminocarboxymuconate semialdehyde decarboxylase |
| Notes | The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004] |
| GO Molecular Function | catalytic activity |
|---|---|
| lyase activity | |
| carboxy-lyase activity | |
| aminocarboxymuconate-semialdehyde decarboxylase activity | |
| metal ion binding |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| tryptophan catabolic process | |
| tryptophan metabolic process | |
| quinolinate metabolic process | |
| nicotinamide metabolic process | |
| cellular nitrogen compound metabolic process |
| Pathway | kynurenine metabolic pathway |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| metabolic process | |
| small molecule metabolic process | |
| tryptophan catabolic process | |
| tryptophan metabolic process | |
| quinolinate metabolic process | |
| nicotinamide metabolic process | |
| catalytic activity | |
| lyase activity | |
| carboxy-lyase activity | |
| aminocarboxymuconate-semialdehyde decarboxylase activity | |
| cellular nitrogen compound metabolic process | |
| metal ion binding | |
| cytosol |
| LocusLink ID | 130013 |
|---|---|
| 266645 | |
| 171385 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0001760 |
|---|---|
| 0046872 | |
| 0034641 | |
| 0046874 | |
| 0044281 | |
| 0006569 | |
| 0005829 | |
| 0016831 | |
| 0003824 | |
| 0016829 | |
| 0008152 | |
| 0006769 | |
| 0006568 |
| Alias | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
|---|---|
| picolinate carboxylase | |
| OTTHUMP00000162500 | |
| picolinic acid decarboxylase | |
| picolinic acid carboxylases | |
| picolinic acid carboxylase | |
| aminocarboxymuconate semialdehyde decarboxylase | |
| OTTHUMP00000162501 | |
| picolinic acid decarboxylases | |
| amino carboxymuconate semialdehyde decarboxylase | |
| ACMSD | |
| alpha-amino-beta-carboxymuconate-e-semialdehade decarboxylase | |
| alpha-amino-beta-carboxymuconate-e-semialdehade decarboxylases | |
| alpha-amino-beta-carboxymuconate-e-semialdehyde beta-decarboxylase | |
| alpha-amino-beta-carboxymuconate-e-semialdehyde beta-decarboxylases |
| Mouse chromosome position | 1 |
|---|
| OMIM ID | 608889 |
|---|
| Rat chromosome position | 13q12 |
|---|
| Hugo ID | 19288 |
|---|
| Human chromosome position | 2q21.3 |
|---|
| Swiss-Prot Accession | Q8TDX5 |
|---|---|
| Q8R519 | |
| Q8R5M5 | |
| B9EI97 | |
| Q3UNW3 | |
| Q3B7X3 | |
| Q53SR5 | |
| Q96KY2 |
| Unigene ID | Hs.655728 |
|---|---|
| Mm.25735 | |
| Rn.162389 |
| KEGG ID | hsa:130013 |
|---|---|
| mmu:266645 | |
| rno:171385 |
| Swiss-Prot ID | ACMSD_MOUSE |
|---|---|
| ACMSD_RAT | |
| ACMSD_HUMAN |
| EC Number | 4.1.1.45 |
|---|
| Ensembl ID | ENSG00000153086 |
|---|---|
| ENSP00000348459 | |
| ENST00000356140 | |
| ENSP00000376659 | |
| ENST00000392928 | |
| ENSP00000283054 | |
| ENST00000283054 | |
| ENSMUSG00000026348 | |
| ENSMUSP00000048482 | |
| ENSMUST00000038006 | |
| ENSRNOG00000003884 | |
| ENSRNOP00000005206 | |
| ENSRNOT00000005206 |
| Homologene ID | 44520 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2386323 |
|---|
| RGD ID | 620868 |
|---|
| MedScan ID | 130013 |
|---|