| URN | urn:agi-llid:8942 |
|---|---|
| Total Entities | 0 |
| Connectivity | 70 |
| Name | Kynu |
| Description | kynureninase |
| Notes | Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| kynureninase activity | |
| protein homodimerization activity | |
| pyridoxal phosphate binding |
| GO Cellular Component | nucleolus |
|---|---|
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| response to interferon-gamma | |
| small molecule metabolic process | |
| quinolinate biosynthetic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| L-kynurenine catabolic process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| tryptophan catabolic process to acetyl-CoA | |
| anthranilate metabolic process | |
| response to vitamin B6 | |
| cellular nitrogen compound metabolic process |
| Pathway | kynurenine metabolic pathway |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| metabolic process | |
| response to interferon-gamma | |
| small molecule metabolic process | |
| quinolinate biosynthetic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| L-kynurenine catabolic process | |
| tryptophan catabolic process | |
| tryptophan catabolic process to kynurenine | |
| tryptophan catabolic process to acetyl-CoA | |
| anthranilate metabolic process | |
| response to vitamin B6 | |
| catalytic activity | |
| hydrolase activity | |
| kynureninase activity | |
| cellular nitrogen compound metabolic process | |
| protein homodimerization activity | |
| pyridoxal phosphate binding | |
| nucleolus | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 8942 |
|---|---|
| 70789 | |
| 116682 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0030429 |
|---|---|
| 0042803 | |
| 0030170 | |
| 0097053 | |
| 0009435 | |
| 0043420 | |
| 0034641 | |
| 0019805 | |
| 0034341 | |
| 0034516 | |
| 0044281 | |
| 0006569 | |
| 0019442 | |
| 0019441 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0005730 | |
| 0005634 | |
| 0003824 | |
| 0016787 | |
| 0008152 | |
| 0019363 |
| Alias | kynureninase |
|---|---|
| kynureninase (L-kynurenine hydrolase) | |
| 4432411A05Rik | |
| RP23-303O15.1 | |
| L-kynurenine hydrolase | |
| OTTMUSP00000013231 | |
| OTTMUSP00000013230 | |
| OTTHUMP00000204304 | |
| KYNU | |
| 4432411A05 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 605197 |
|---|
| Rat chromosome position | 3q12 |
|---|
| Hugo ID | 6469 |
|---|
| Human chromosome position | 2q22.2 |
|---|
| Swiss-Prot Accession | Q16719 |
|---|---|
| A2ARD6 | |
| Q9CXF0 | |
| P70712 | |
| B2RCZ5 | |
| D3DP79 | |
| Q6I9T2 | |
| Q9BVW3 | |
| Q68G25 | |
| Q7M0D0 | |
| Q9QW90 |
| PIR ID | G02652 |
|---|---|
| PS0370 | |
| S59898 | |
| T48675 |
| Unigene ID | Hs.470126 |
|---|---|
| Mm.105278 | |
| Rn.10575 |
| KEGG ID | hsa:8942 |
|---|---|
| mmu:70789 | |
| rno:116682 |
| Swiss-Prot ID | KYNU_HUMAN |
|---|---|
| KYNU_MOUSE | |
| KYNU_RAT |
| EC Number | 3.7.1.3 |
|---|
| Ensembl ID | ENSG00000115919 |
|---|---|
| ENSP00000364928 | |
| ENST00000375773 | |
| ENSP00000386731 | |
| ENST00000409512 | |
| ENSP00000264170 | |
| ENST00000264170 | |
| ENSMUSG00000026866 | |
| ENSMUSP00000028223 | |
| ENSMUST00000028223 | |
| ENSRNOG00000029993 | |
| ENSRNOP00000050947 | |
| ENSRNOT00000043533 |
| Homologene ID | 2925 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1918039 |
|---|
| RGD ID | 71061 |
|---|
| MedScan ID | 8942 |
|---|