| URN | urn:agi-llid:23498 |
|---|---|
| Total Entities | 0 |
| Connectivity | 28 |
| Name | Haao |
| Description | 3-hydroxyanthranilate 3,4-dioxygenase |
| Notes | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| dioxygenase activity | |
| 3-hydroxyanthranilate 3,4-dioxygenase activity | |
| electron carrier activity | |
| oxygen binding | |
| metal ion binding | |
| iron ion binding | |
| ferrous iron binding |
| GO Cellular Component | mitochondrial membrane |
|---|---|
| cytoplasm | |
| cytosol |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| quinolinate biosynthetic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| tryptophan catabolic process | |
| quinolinate metabolic process | |
| neuron cellular homeostasis | |
| response to cadmium ion | |
| response to zinc ion | |
| cellular nitrogen compound metabolic process |
| Pathway | kynurenine metabolic pathway |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| quinolinate biosynthetic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| tryptophan catabolic process | |
| oxidoreductase activity | |
| dioxygenase activity | |
| 3-hydroxyanthranilate 3,4-dioxygenase activity | |
| quinolinate metabolic process | |
| neuron cellular homeostasis | |
| response to cadmium ion | |
| response to zinc ion | |
| cellular nitrogen compound metabolic process | |
| electron carrier activity | |
| oxygen binding | |
| metal ion binding | |
| iron ion binding | |
| ferrous iron binding | |
| mitochondrial membrane | |
| cytoplasm | |
| cytosol |
| LocusLink ID | 23498 |
|---|---|
| 107766 | |
| 56823 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0000334 |
|---|---|
| 0009055 | |
| 0008198 | |
| 0019825 | |
| 0009435 | |
| 0034641 | |
| 0070050 | |
| 0019805 | |
| 0046686 | |
| 0010043 | |
| 0044281 | |
| 0006569 | |
| 0005829 | |
| 0031966 | |
| 0051213 | |
| 0005506 | |
| 0046872 | |
| 0016491 | |
| 0055114 | |
| 0019363 | |
| 0046874 | |
| 0005737 |
| Alias | HAO |
|---|---|
| 3-HAO | |
| 3-hydroxyanthranilate 3,4-dioxygenase | |
| HAD | |
| 3-hydroxyanthranilate oxygenase | |
| 3-hydroxyanthranilic acid dioxygenase | |
| 3HAO | |
| 3-HAOxase | |
| 0610007K21Rik | |
| 0610012J07Rik | |
| 3-hydroxyanthranilic acid oxidases | |
| 3-hydroxyanthranilic oxygenase | |
| RIKEN cDNA 0610012J07 gene | |
| RIKEN cDNA 0610007K21 gene | |
| 3-hydroxyanthranilic oxygenases | |
| 3-hydroxyanthranilic acid oxygenases | |
| 3-hydroxyanthranilic acid oxygenase | |
| 0610007K21 | |
| 3- hydroxyanthranilic acid dioxygenase | |
| 0610012J07 | |
| HAAO | |
| 3-hydroxyanthranilic acid oxidase |
| Mouse chromosome position | 17 |
|---|
| OMIM ID | 604521 |
|---|
| Rat chromosome position | 6q12 |
|---|
| Hugo ID | 4796 |
|---|
| Human chromosome position | 2p21 |
|---|
| Swiss-Prot Accession | P46952 |
|---|---|
| Q78JT3 | |
| P46953 | |
| Q52L88 | |
| P70474 | |
| Q5RKK0 | |
| Q64556 | |
| A6NE56 | |
| B4DIN2 | |
| Q53QZ7 | |
| Q8N6N9 |
| PIR ID | A54070 |
|---|
| Unigene ID | Hs.368805 |
|---|---|
| Mm.30100 | |
| Rn.48675 |
| KEGG ID | hsa:23498 |
|---|---|
| mmu:107766 | |
| rno:56823 |
| Swiss-Prot ID | 3HAO_MOUSE |
|---|---|
| 3HAO_RAT | |
| 3HAO_HUMAN |
| EC Number | 1.13.11.6 |
|---|
| Ensembl ID | ENSG00000162882 |
|---|---|
| ENSP00000294973 | |
| ENST00000294973 | |
| ENSMUSG00000000673 | |
| ENSMUSP00000000687 | |
| ENSMUST00000000687 | |
| ENSRNOG00000031263 | |
| ENSRNOP00000043835 | |
| ENSRNOT00000045996 |
| Homologene ID | 8148 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1349444 |
|---|
| RGD ID | 71071 |
|---|
| MedScan ID | 23498 |
|---|