| URN | urn:agi-llid:9536 |
|---|---|
| Total Entities | 0 |
| Connectivity | 527 |
| Name | Ptges |
| Description | prostaglandin E synthase |
| Notes | The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | glutathione binding |
|---|---|
| isomerase activity | |
| prostaglandin-E synthase activity | |
| prostaglandin-D synthase activity |
| GO Cellular Component | membrane |
|---|---|
| nuclear envelope lumen | |
| integral to membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| intracellular membrane-bounded organelle | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| signal transduction | |
| negative regulation of cell proliferation | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| response to calcium ion | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to retinoic acid | |
| acute inflammatory response | |
| chronic inflammatory response | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| prostaglandin metabolic process |
| Pathway | TLR4/AP-1/EGR1/HIF1A Expression Targets |
|---|---|
| prostanoid biosynthetic pathway |
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| metabolic process | |
| signal transduction | |
| negative regulation of cell proliferation | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| response to calcium ion | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to retinoic acid | |
| acute inflammatory response | |
| chronic inflammatory response | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| prostaglandin metabolic process | |
| glutathione binding | |
| isomerase activity | |
| prostaglandin-E synthase activity | |
| prostaglandin-D synthase activity | |
| membrane | |
| nuclear envelope lumen | |
| integral to membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 9536 |
|---|
| Hugo ID | 9599 |
|---|
| Human chromosome position | 9q34.3 |
|---|
| LocusLink ID | 9536 |
|---|---|
| 64292 | |
| 59103 |
| Alias | PGES |
|---|---|
| MPGES | |
| PIG12 | |
| PP102 | |
| PP1294 | |
| MGST-IV | |
| MGST1L1 | |
| TP53I12 | |
| mPGES-1 | |
| MGST1-L1 | |
| prostaglandin E synthase | |
| MGST1-like 1 | |
| p53-induced gene 12 protein | |
| p53-induced apoptosis protein 12 | |
| glutathione S-transferase 1-like 1 | |
| microsomal prostaglandin E synthase 1 | |
| microsomal prostaglandin E synthase-1 | |
| tumor protein p53 inducible protein 12 | |
| microsomal glutathione S-transferase 1-like 1 | |
| D2Ertd369e | |
| 2410099E23Rik | |
| RP23-221O14.6 | |
| tumour protein p53 inducible protein 12 | |
| PP(102) | |
| p53-induced gene XII | |
| p53-induced gene 12 | |
| PP(1294) | |
| OTTMUSP00000012699 | |
| prostaglandin E synthetase | |
| OTTHUMP00000022345 | |
| PP-102 | |
| PTGES | |
| PP-1294 | |
| 2410099E23 | |
| 2410099E23Rik(2) | |
| cPGES | |
| DNA segment, Chr 2, ERATO Doi 369, expressed | |
| glutathione S-transferase 1-like I | |
| MGC10317 | |
| Microsomal glutathione S-transferase 1- like 1 | |
| MGC124930 | |
| MGST-IVs | |
| MGST1-like I | |
| MGST1-L I | |
| microsomal prostaglandin E synthetase-1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605172 |
|---|
| Unigene ID | Hs.146688 |
|---|---|
| Mm.28768 | |
| Rn.7730 |
| KEGG ID | hsa:9536 |
|---|---|
| mmu:64292 | |
| rno:59103 |
| Swiss-Prot Accession | O14684 |
|---|---|
| A2APZ9 | |
| Q8BNP8 | |
| Q9JM51 | |
| Q9JHF3 | |
| Q3T9C5 | |
| O14900 | |
| Q5SZC0 |
| EC Number | 5.3.99.3 |
|---|
| GO ID | 0043295 |
|---|---|
| 0050220 | |
| 0008285 | |
| 0001516 | |
| 0006693 | |
| 0007165 | |
| 0005737 | |
| 0016021 | |
| 0016020 | |
| 0005641 | |
| 0016853 | |
| 0004667 | |
| 0006633 | |
| 0006631 | |
| 0006629 | |
| 0008152 | |
| 0043231 | |
| 0005634 | |
| 0048471 | |
| 0002526 | |
| 0002544 | |
| 0051592 | |
| 0034097 | |
| 0032496 | |
| 0014070 | |
| 0032526 |
| Swiss-Prot ID | PTGES_MOUSE |
|---|---|
| PTGES_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00974637 |
|---|---|
| IPI00297858 |
| Mouse chromosome position | 2 24.0 cM |
|---|
| Rat chromosome position | 3p12 |
|---|
| Homologene ID | 3587 |
|---|
| MGI ID | 1927593 |
|---|
| RGD ID | 62076 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|