Protein Tbxas1

URN	urn:agi-llid:6916
Total Entities	0
Connectivity	88
Name	Tbxas1
Description	thromboxane A synthase 1 (platelet)
Notes	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Ariadne Ontology	Prostaglandins, Thromboxane synthesis

GO Molecular Function	electron carrier activity
	heme binding
	metal ion binding
	iron ion binding
	isomerase activity
	oxidoreductase activity
	monooxygenase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
	thromboxane-A synthase activity

GO Cellular Component	membrane
	endoplasmic reticulum membrane
	integral to membrane
	endoplasmic reticulum

GO Biological Process	metabolic process
	xenobiotic metabolic process
	fatty acid biosynthetic process
	fatty acid metabolic process
	cellular chloride ion homeostasis
	positive regulation of vasoconstriction
	lipid metabolic process
	prostaglandin biosynthetic process
	oxidation-reduction process
	small molecule metabolic process
	icosanoid metabolic process
	prostaglandin metabolic process

Pathway	prostanoid biosynthetic pathway

Group	Prostaglandins, Thromboxane synthesis
	metabolic process
	xenobiotic metabolic process
	fatty acid biosynthetic process
	fatty acid metabolic process
	cellular chloride ion homeostasis
	positive regulation of vasoconstriction
	lipid metabolic process
	prostaglandin biosynthetic process
	oxidation-reduction process
	small molecule metabolic process
	icosanoid metabolic process
	prostaglandin metabolic process
	electron carrier activity
	heme binding
	metal ion binding
	iron ion binding
	isomerase activity
	oxidoreductase activity
	monooxygenase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
	thromboxane-A synthase activity
	membrane
	endoplasmic reticulum membrane
	integral to membrane
	endoplasmic reticulum

MedScan ID	6916

Hugo ID	11609

Human chromosome position	7q34-q35

Alias	TS
	TXS
	CYP5
	THAS
	TXAS
	CYP5A1
	GHOSAL
	BDPLT14
	thromboxane-A synthase
	TXA synthase
	cytochrome P450 5A1
	platelet, cytochrome P450, subfamily V
	cytochrome P450, family 5, subfamily A, polypeptide 1
	thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
	ThromboxA ane synthase 1
	ThromboxA ane synthetase I
	ThromboxA ane synthetase 1
	thromboxane A synthetase I
	thromboxane A synthase 1 (platelet)
	thromboxane A synthase I
	thromboxane A synthetase 1
	thromboxane A synthetase 1 (platelet)
	thromboxane A synthase 1
	Thromboxane-A synthetase
	TXS-I
	TXS-II
	ThromboxA ane synthase I
	OTTHUMP00000211928
	TXA synthetase
	FLJ52771
	CYP5A I
	OTTHUMP00000211930
	cytochrome P4505A1
	OTTHUMP00000211927
	Tbxas I
	OTTHUMP00000211931
	P450 (CYP) 5A1
	P450 5A1
	P4505A1
	OTTHUMP00000211929
	Tbxas1

EC Number	5.3.99.5

Cell Localization	Endoplasmic reticulum membrane
	Plasma membrane

Mouse chromosome position	6 20.5 cM

Rat chromosome position	4q21-q22

Homologene ID	55549

MGI ID	98497

RGD ID	3826

Primary Cell Localization	Plasma membrane