| URN | urn:agi-llid:5730 |
|---|---|
| Total Entities | 0 |
| Connectivity | 310 |
| Name | Ptgds |
| Description | prostaglandin D2 synthase 21kDa (brain) |
| Notes | The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | transporter activity |
|---|---|
| small molecule binding | |
| fatty acid binding | |
| retinoid binding | |
| isomerase activity | |
| prostaglandin-D synthase activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| nuclear membrane | |
| nuclear envelope | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| rough endoplasmic reticulum | |
| nucleus | |
| extracellular space |
| GO Biological Process | fatty acid biosynthetic process |
|---|---|
| fatty acid metabolic process | |
| response to glucocorticoid stimulus | |
| regulation of circadian sleep-wake cycle, sleep | |
| transport | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| prostaglandin metabolic process |
| Pathway | TLR4/AP-1 Expression Targets |
|---|---|
| IL1B Expression Targets | |
| prostanoid biosynthetic pathway |
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| response to glucocorticoid stimulus | |
| regulation of circadian sleep-wake cycle, sleep | |
| transport | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| prostaglandin metabolic process | |
| transporter activity | |
| small molecule binding | |
| fatty acid binding | |
| retinoid binding | |
| isomerase activity | |
| prostaglandin-D synthase activity | |
| membrane | |
| extracellular region | |
| nuclear membrane | |
| nuclear envelope | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| rough endoplasmic reticulum | |
| nucleus | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5730 |
|---|
| Hugo ID | 9592 |
|---|
| Human chromosome position | 9q34.2-q34.3 |
|---|
| LocusLink ID | 5730 |
|---|---|
| 19215 | |
| 25526 |
| Alias | PDS |
|---|---|
| PGD2 | |
| PGDS | |
| LPGDS | |
| PGDS2 | |
| L-PGDS | |
| RP11-229P13.6 | |
| prostaglandin-H2 D-isomerase | |
| cerebrin-28 | |
| PGD2 synthase | |
| beta-trace protein | |
| prostaglandin D synthase | |
| prostaglandin-D2 synthase | |
| glutathione-independent PGD synthase | |
| glutathione-independent PGD synthetase | |
| lipocalin-type prostaglandin D synthase | |
| lipocalin-type prostaglandin-D synthase | |
| 21kDa | |
| Ptgs3 | |
| RP23-47P18.11-006 | |
| prostaglandin D2 synthase (21 kDa, brain) | |
| PH2DISO | |
| Prostaglandin D2 synthetase | |
| prostaglandin D synthetase | |
| Prostaglandin D2 synthase | |
| prostaglandin D2 synthase (21kD, brain) | |
| prostaglandin D2 synthase (brain) | |
| prostaglandin D2 synthase 21kDa | |
| prostaglandin D2 synthetase (21 kDa, brain) | |
| prostaglandin D2 synthetase (21kD, brain) | |
| RP23-47P18.11 | |
| prostaglandin D2 synthetase (brain) | |
| prostaglandin H2 D-isomerase | |
| PTGDS | |
| prostaglandin D2 synthetase 21kDa | |
| 21kDa prostaglandin D2 synthetase | |
| 21kDa prostaglandin D2 synthase | |
| PGD2S | |
| hPGD2S | |
| lipocalin-type prostaglandin-D synthetase | |
| PGD2 synthetase | |
| OTTMUSP00000013069 | |
| OTTMUSP00000013068 | |
| OTTMUSP00000013067 | |
| OTTHUMP00000022642 | |
| OTTHUMP00000022640 | |
| OTTHUMP00000022638 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 176803 |
|---|
| Unigene ID | Hs.446429 |
|---|---|
| Mm.1008 | |
| Rn.11400 |
| KEGG ID | hsa:5730 |
|---|---|
| mmu:19215 | |
| rno:25526 |
| Swiss-Prot Accession | P41222 |
|---|---|
| O09114 | |
| Q3V2G5 | |
| P22057 | |
| O09157 | |
| O35091 | |
| Q62169 | |
| B2R727 | |
| Q5SQ10 | |
| Q7M4P3 | |
| Q9UC22 | |
| Q9UCC9 | |
| Q9UCD9 |
| EC Number | 5.3.99.2 |
|---|
| GO ID | 0005504 |
|---|---|
| 0004667 | |
| 0005501 | |
| 0036094 | |
| 0005215 | |
| 0001516 | |
| 0045187 | |
| 0051384 | |
| 0006810 | |
| 0005794 | |
| 0005576 | |
| 0005615 | |
| 0031965 | |
| 0048471 | |
| 0005791 | |
| 0016853 | |
| 0006633 | |
| 0006631 | |
| 0006629 | |
| 0006693 | |
| 0005737 | |
| 0005783 | |
| 0016020 | |
| 0005634 | |
| 0005635 |
| PIR ID | S57748 |
|---|---|
| A32202 | |
| S65717 | |
| A44455 | |
| PH1567 |
| Swiss-Prot ID | PTGDS_MOUSE |
|---|---|
| PTGDS_RAT | |
| PTGDS_HUMAN |
| Cell Localization | Rough endoplasmic reticulum |
|---|---|
| Nucleus membrane | |
| Golgi apparatus | |
| Cytoplasm | |
| perinuclear region | |
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00114252 |
|---|---|
| IPI01016182 | |
| IPI00203102 | |
| IPI00013179 |
| Mouse chromosome position | 2 12.9 cM |
|---|
| Rat chromosome position | 3p13 |
|---|
| Homologene ID | 737 |
|---|
| MGI ID | 99261 |
|---|
| RGD ID | 3433 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|