Protein Ptgs1

URN	urn:agi-llid:5742
Total Entities	0
Connectivity	925
Name	Ptgs1
Description	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Notes	This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Ariadne Ontology	Prostaglandins, Thromboxane synthesis
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	lipid binding
	heme binding
	metal ion binding
	oxidoreductase activity
	prostaglandin-endoperoxide synthase activity
	peroxidase activity
	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

GO Cellular Component	membrane
	endoplasmic reticulum membrane
	nuclear envelope
	plasma membrane
	cytoplasmic part
	cytoplasm
	endoplasmic reticulum
	Golgi apparatus
	intracellular membrane-bounded organelle
	nucleus
	photoreceptor outer segment

GO Biological Process	maintenance of blood-brain barrier
	regulation of cell proliferation
	negative regulation of epinephrine secretion
	negative regulation of norepinephrine secretion
	keratinocyte differentiation
	xenobiotic metabolic process
	fatty acid biosynthetic process
	fatty acid metabolic process
	cyclooxygenase pathway
	response to organic nitrogen
	response to corticosterone stimulus
	response to fatty acid
	response to oxidative stress
	learning
	memory
	positive regulation of vasoconstriction
	positive regulation of smooth muscle contraction
	aging
	sensory perception of pain
	lipid metabolic process
	prostaglandin biosynthetic process
	oxidation-reduction process
	small molecule metabolic process
	prostaglandin metabolic process
	regulation of blood pressure

Pathway	ROS and RNS in Regulation of Vasoconstriction and Vasodilation
	TNF/CREB Expression Targets
	TNF/ELK-SRF Expression Targets
	TNF/NF-kB Expression Targets
	TLR4/AP-1/EGR1/HIF1A Expression Targets
	TNF/AP-1 Expression Targets
	paracetamol drug pathway
	prostanoid biosynthetic pathway

Group	Prostaglandins, Thromboxane synthesis
	maintenance of blood-brain barrier
	regulation of cell proliferation
	negative regulation of epinephrine secretion
	negative regulation of norepinephrine secretion
	keratinocyte differentiation
	xenobiotic metabolic process
	fatty acid biosynthetic process
	fatty acid metabolic process
	cyclooxygenase pathway
	response to organic nitrogen
	response to corticosterone stimulus
	response to fatty acid
	response to oxidative stress
	learning
	memory
	positive regulation of vasoconstriction
	positive regulation of smooth muscle contraction
	aging
	sensory perception of pain
	lipid metabolic process
	prostaglandin biosynthetic process
	oxidation-reduction process
	small molecule metabolic process
	prostaglandin metabolic process
	regulation of blood pressure
	lipid binding
	heme binding
	metal ion binding
	oxidoreductase activity
	prostaglandin-endoperoxide synthase activity
	peroxidase activity
	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
	membrane
	endoplasmic reticulum membrane
	nuclear envelope
	plasma membrane
	cytoplasmic part
	cytoplasm
	endoplasmic reticulum
	Golgi apparatus
	intracellular membrane-bounded organelle
	nucleus
	photoreceptor outer segment
	Secreted proteins
	Biofluids assayable substances

MedScan ID	5742

Hugo ID	9604

Human chromosome position	9q32-q33.3

Alias	COX1
	COX3
	PHS1
	PCOX1
	PES-1
	PGHS1
	PTGHS
	PGG/HS
	PGHS-1
	RP11-542K23.6
	prostaglandin G/H synthase 1
	PGH synthase 1
	cyclooxygenase-1
	prostaglandin H2 synthase 1
	Cox-1
	Cox-3
	PHS 1
	RP23-454A14.3
	cyclooxygenase 1
	cyclooxygenase 3
	prostaglandin G/H synthase and cyclooxygenase
	prostaglandin-endoperoxide synthase 1 isoform 1
	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
	prostaglandin-endoperoxide synthase 1
	Prostaglandin H2 synthetase I
	prostaglandin-endoperoxide synthase 1 isoform 2
	Prostaglandin H2 synthase I
	prostaglandin-endoperoxide synthetase 1 isoform 2
	prostaglandin G/H synthetase and cyclooxygenase I
	prostaglandin G/H synthetase and cyclooxygenase 1
	Prostaglandin H2 synthetase 1
	prostaglandin-endoperoxide synthase I
	prostaglandin-endoperoxide synthetase 1
	prostaglandin-endoperoxide synthetase 1 isoform 1
	prostaglandin-endoperoxide synthetase I
	Ptgs I
	Ptgs1
	prostaglandin G/H synthase and cyclooxygenase 1
	prostaglandin G/H synthetase and cyclooxygenase
	prostaglandin-endoperoxide synthetase 1 (prostaglandin G/H synthetase and cyclooxygenase)
	PCOX I
	prostaglandin G/H synthase and cyclooxygenase I
	Prostaglandin G/H synthetase 1
	LOC360359
	LOC497767
	OTTHUMP00000022052
	OTTMUSP00000013094
	PHS I
	OTTHUMP00000022053
	PGH synthase I
	Cyclooxygenase I
	PGHS I
	PGH synthetase I
	PGH synthetase 1

OMIM ID	176805

EC Number	1.14.99.1

Cell Localization	Microsome membrane
	Endoplasmic reticulum membrane
	Plasma membrane

Mouse chromosome position	2 29.0 cM

Rat chromosome position	3p11

Homologene ID	743

MGI ID	97797

RGD ID	3439

Primary Cell Localization	Plasma membrane