| URN | urn:agi-llid:27306 |
|---|---|
| Total Entities | 0 |
| Connectivity | 61 |
| Name | Hpgds |
| Description | hematopoietic prostaglandin D synthase |
| Notes | Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|
| GO Molecular Function | protein homodimerization activity |
|---|---|
| magnesium ion binding | |
| calcium ion binding | |
| isomerase activity | |
| transferase activity | |
| glutathione transferase activity | |
| prostaglandin-D synthase activity |
| GO Cellular Component | nucleolus |
|---|---|
| cytoplasm | |
| nucleus |
| GO Biological Process | signal transduction |
|---|---|
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| locomotory behavior | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| prostaglandin metabolic process |
| Pathway | prostanoid biosynthetic pathway |
|---|
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| signal transduction | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| locomotory behavior | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| prostaglandin metabolic process | |
| protein homodimerization activity | |
| magnesium ion binding | |
| calcium ion binding | |
| isomerase activity | |
| transferase activity | |
| glutathione transferase activity | |
| prostaglandin-D synthase activity | |
| nucleolus | |
| cytoplasm | |
| nucleus |
| MedScan ID | 27306 |
|---|
| Hugo ID | 17890 |
|---|
| Human chromosome position | 4q22.3 |
|---|
| LocusLink ID | 27306 |
|---|---|
| 54486 | |
| 58962 |
| Alias | GSTS |
|---|---|
| PGD2 | |
| PGDS | |
| GSTS1-1 | |
| hematopoietic prostaglandin D synthase | |
| GST class-sigma | |
| prostaglandin-H2 D-isomerase | |
| glutathione S-transferase sigma | |
| glutathione-dependent PGD synthase | |
| glutathione-dependent PGD synthetase | |
| hematopoietic prostaglandin D2 synthase | |
| glutathione-requiring prostaglandin D synthase | |
| H-PGDS | |
| Ptgds2 | |
| glutathione S-transferase | |
| prostaglandin D2 synthase 2, hematopoietic | |
| prostaglandin D2 synthase II | |
| MGC105397 | |
| MGC151112 | |
| MGC151114 | |
| prostaglandin D2 synthase 2 | |
| prostaglandin D2 synthetase 2 | |
| prostaglandin D2 synthetase 2, hematopoietic | |
| prostaglandin D2 synthetase II | |
| prostaglandin D2 synthetase, hematopoietic | |
| prostaglandin D2 synthase, hematopoietic | |
| 1IYH_C | |
| glutathione-requiring prostaglandin D synthetase | |
| hPGDS | |
| 1IYH_A | |
| hematopoietic prostaglandin D2 synthetase | |
| hematopoietic prostaglandin synthase | |
| hematopoietic prostaglandin synthetase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602598 |
|---|
| Unigene ID | Hs.128433 |
|---|---|
| Mm.410688 | |
| Rn.10837 |
| KEGG ID | hsa:27306 |
|---|---|
| mmu:54486 | |
| rno:58962 |
| Swiss-Prot Accession | O60760 |
|---|---|
| Q9JHF7 | |
| O35543 | |
| Q6FHT9 | |
| O35351 | |
| Q14AR4 | |
| Q8CA80 |
| EC Number | 5.3.99.2 |
|---|---|
| 2.5.1.18 |
| GO ID | 0005509 |
|---|---|
| 0004364 | |
| 0000287 | |
| 0004667 | |
| 0042803 | |
| 0007626 | |
| 0001516 | |
| 0006693 | |
| 0007165 | |
| 0005737 | |
| 0005730 | |
| 0005634 | |
| 0016853 | |
| 0016740 | |
| 0006633 | |
| 0006631 | |
| 0006629 |
| Swiss-Prot ID | HPGDS_HUMAN |
|---|---|
| HPGDS_RAT | |
| HPGDS_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Plasma membrane |
| IPI ID | IPI00219303 |
|---|---|
| IPI00231248 | |
| IPI00331387 |
| Mouse chromosome position | 6 |
|---|
| Rat chromosome position | 4q31 |
|---|
| Homologene ID | 113741 |
|---|
| MGI ID | 1859384 |
|---|
| RGD ID | 69251 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|