| URN | urn:agi-llid:80142 |
|---|---|
| Total Entities | 0 |
| Connectivity | 84 |
| Name | Ptges2 |
| Description | prostaglandin E synthase 2 |
| Notes | The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009] |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | electron carrier activity |
|---|---|
| DNA binding | |
| isomerase activity | |
| protein disulfide oxidoreductase activity | |
| prostaglandin-E synthase activity |
| GO Cellular Component | membrane |
|---|---|
| Golgi membrane | |
| integral to membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| cytosol | |
| Golgi apparatus | |
| nucleus |
| GO Biological Process | cell redox homeostasis |
|---|---|
| positive regulation of transcription, DNA-dependent | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| secretion | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| oxidation-reduction process | |
| prostaglandin metabolic process |
| Pathway | prostanoid biosynthetic pathway |
|---|
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| cell redox homeostasis | |
| positive regulation of transcription, DNA-dependent | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| secretion | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| oxidation-reduction process | |
| prostaglandin metabolic process | |
| electron carrier activity | |
| DNA binding | |
| isomerase activity | |
| protein disulfide oxidoreductase activity | |
| prostaglandin-E synthase activity | |
| membrane | |
| Golgi membrane | |
| integral to membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| cytosol | |
| Golgi apparatus | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 80142 |
|---|
| Hugo ID | 17822 |
|---|
| Human chromosome position | 9q34.11 |
|---|
| LocusLink ID | 80142 |
|---|---|
| 96979 | |
| 311865 |
| Alias | GBF1 |
|---|---|
| GBF-1 | |
| PGES2 | |
| C9orf15 | |
| mPGES-2 | |
| RP11-395P17.2 | |
| prostaglandin E synthase 2 | |
| GATE-binding factor 1 | |
| microsomal prostaglandin E synthase-2 | |
| membrane-associated prostaglandin E synthase 2 | |
| gamma-interferon-activated transcriptional element-binding factor 1 | |
| C79137 | |
| Mpges2 | |
| 0610038H10Rik | |
| RP23-375I1.1 | |
| microsomal prostaglandin E synthase 2 | |
| PGE2 isomerases | |
| prostaglandin E synthetase II | |
| prostaglandin E synthetase 2 | |
| prostaglandin E synthase II | |
| PGH-PGE isomerases | |
| prostaglandin endoperoxide E isomerase | |
| prostaglandin H-E isomerases | |
| PGE2 isomerase | |
| PGE isomerases | |
| PGE isomerase | |
| PGH-PGE isomerase | |
| prostaglandin endoperoxide E isomerases | |
| prostaglandin endoperoxide E2 isomerase | |
| prostaglandin H-E isomerase | |
| prostaglandin R-prostaglandin E isomerase | |
| prostaglandin R-prostaglandin E isomerases | |
| prostaglandin-H2 E-isomerase | |
| prostaglandin-H2 E-isomerases | |
| PTGES2 | |
| OTTMUSP00000012850 | |
| prostaglandin endoperoxide E2 isomerases | |
| 0610038H10 | |
| chromosome 9 open reading frame 15 | |
| endoperoxide isomerase | |
| endoperoxide isomerases | |
| FLJ14038 | |
| GBF I | |
| gamma-interferon-activated transcriptional element (GATE) binding factor I | |
| OTTHUMP00000215363 | |
| gamma-interferon-activated transcriptional element-binding factor I | |
| microsomal prostaglandin E synthetase-2 | |
| OTTHUMP00000022232 | |
| gamma-interferon-activated transcriptional element (GATE) binding factor 1 | |
| gate-binding factor I | |
| MGC6845 | |
| MGC11289 | |
| membrane-associated prostaglandin E synthetase II | |
| membrane-associated prostaglandin E synthetase 2 | |
| membrane-associated prostaglandin E synthase II | |
| OTTHUMP00000022231 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608152 |
|---|
| Unigene ID | Hs.495219 |
|---|---|
| Mm.28048 | |
| Rn.39290 |
| KEGG ID | hsa:80142 |
|---|---|
| mmu:96979 | |
| rno:311865 |
| Swiss-Prot Accession | A6NHH0 |
|---|---|
| Q9H7Z7 | |
| B3KPZ2 | |
| Q8BWM0 | |
| D4AE56 | |
| A2ASQ2 | |
| Q99J30 | |
| Q53EW9 | |
| Q5SYV6 | |
| Q96GI0 | |
| Q96GL2 |
| EC Number | 5.3.99.3 |
|---|
| GO ID | 0003677 |
|---|---|
| 0009055 | |
| 0050220 | |
| 0015035 | |
| 0045454 | |
| 0045893 | |
| 0001516 | |
| 0046903 | |
| 0000139 | |
| 0005829 | |
| 0016021 | |
| 0005739 | |
| 0005634 | |
| 0048471 | |
| 0016853 | |
| 0006633 | |
| 0006631 | |
| 0006629 | |
| 0055114 | |
| 0006693 | |
| 0005794 | |
| 0005737 | |
| 0016020 |
| Swiss-Prot ID | PGES2_MOUSE |
|---|---|
| PGES2_HUMAN |
| Cell Localization | Golgi apparatus membrane |
|---|---|
| Nucleus | |
| Cytoplasm | |
| perinuclear region | |
| Plasma membrane |
| IPI ID | IPI00312174 |
|---|---|
| IPI00303568 |
| Mouse chromosome position | 2 |
|---|
| Rat chromosome position | 3p11 |
|---|
| Homologene ID | 11819 |
|---|
| MGI ID | 1917592 |
|---|
| RGD ID | 1310836 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|