Protein Akr1b1

URN	urn:agi-llid:231
Total Entities	0
Connectivity	191
Name	Akr1b1
Description	aldo-keto reductase family 1, member B1 (aldose reductase)
Notes	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Ariadne Ontology	Triacylglycerols biosynthesis
	Glucose metabolism
	Phospholipid biosynthesis
	Biofluids assayable substances

GO Molecular Function	electron carrier activity
	oxidoreductase activity
	aldo-keto reductase (NADP) activity
	alditol:NADP+ 1-oxidoreductase activity
	glyceraldehyde oxidoreductase activity

GO Biological Process	positive regulation of JAK-STAT cascade
	stress-activated protein kinase signaling cascade
	positive regulation of smooth muscle cell proliferation
	sorbitol biosynthetic process
	C21-steroid hormone biosynthetic process
	response to stress
	response to organic substance
	carbohydrate metabolic process
	steroid metabolic process
	oxidation-reduction process
	small molecule metabolic process
	doxorubicin metabolic process
	daunorubicin metabolic process

Pathway	prostanoid biosynthetic pathway

Group	Triacylglycerols biosynthesis
	Glucose metabolism
	Phospholipid biosynthesis
	positive regulation of JAK-STAT cascade
	stress-activated protein kinase signaling cascade
	positive regulation of smooth muscle cell proliferation
	sorbitol biosynthetic process
	C21-steroid hormone biosynthetic process
	response to stress
	response to organic substance
	carbohydrate metabolic process
	steroid metabolic process
	oxidation-reduction process
	small molecule metabolic process
	doxorubicin metabolic process
	daunorubicin metabolic process
	electron carrier activity
	oxidoreductase activity
	aldo-keto reductase (NADP) activity
	alditol:NADP+ 1-oxidoreductase activity
	glyceraldehyde oxidoreductase activity
	nucleolus
	cytoplasm
	cytosol
	nucleus
	extracellular space
	Biofluids assayable substances

MedScan ID	231
	601354

Hugo ID	381

Human chromosome position	7q35

Alias	AR
	ADR
	ALR2
	ALDR1
	aldose reductase
	aldehyde reductase 1
	low Km aldose reductase
	Lii5-2 CTCL tumor antigen
	aldo-keto reductase family 1 member B1
	Ahr1
	Ahr-1
	Akr1b1
	Aldor1
	aldo-keto reductase family 1, member B1 (aldose reductase)
	Akr1b3p
	EG626009
	mCG_117541
	Alr
	ALDRED
	Akr1b3
	Akr1b4
	ALR-P-I
	RATALDRED
	aldo-keto reductase family 1, member B4 (aldose reductase)
	Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
	Lii5-2 CTCL tumour antigen
	ALDR I
	LOC214223
	MGC1804
	OTTHUMP00000207728
	OTTMUSP00000015654
	Ahr I
	Akr1b I
	Aldor I
	aldehyde reductase I
	aldo-keto reductase family 1, member B1
	aldo-keto reductase family 1, member B3 (aldose reductase)
	LOC632243
	Gm6644

OMIM ID	103880

EC Number	1.1.1.21

Cell Localization	Cytoplasm
	Mitochondria

Mouse chromosome position	6 13.0 cM
	1

Rat chromosome position	4q22

MGI ID	1353494
	3644951

RGD ID	2092

Primary Cell Localization	Cytoplasm
	Mitochondria