| URN | urn:agi-llid:8644 |
|---|---|
| Total Entities | 0 |
| Connectivity | 220 |
| Name | Akr1c3 |
| Description | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) |
| Notes | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|---|
| Secreted proteins |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| geranylgeranyl reductase activity | |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | |
| delta4-3-oxosteroid 5beta-reductase activity | |
| phenanthrene 9,10-monooxygenase activity | |
| ketosteroid monooxygenase activity | |
| oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor | |
| ketoreductase activity | |
| prostaglandin-F synthase activity | |
| aldo-keto reductase (NADP) activity | |
| 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity | |
| indanol dehydrogenase activity | |
| retinol dehydrogenase activity | |
| prostaglandin D2 11-ketoreductase activity | |
| 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase (NAD+) activity | |
| dihydrotestosterone 17-beta-dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase (NADP+) activity | |
| androsterone dehydrogenase activity | |
| androsterone dehydrogenase (A-specific) activity | |
| alditol:NADP+ 1-oxidoreductase activity | |
| retinal dehydrogenase activity | |
| prostaglandin F receptor activity |
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | parturition |
|---|---|
| regulation of retinoic acid receptor signaling pathway | |
| positive regulation of protein kinase B signaling cascade | |
| cellular response to starvation | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of reactive oxygen species metabolic process | |
| negative regulation of retinoic acid biosynthetic process | |
| regulation of testosterone biosynthetic process | |
| positive regulation of cell proliferation | |
| positive regulation of cell death | |
| positive regulation of endothelial cell apoptotic process | |
| keratinocyte differentiation | |
| retinal metabolic process | |
| farnesol catabolic process | |
| progesterone metabolic process | |
| testosterone biosynthetic process | |
| progesterone catabolic process | |
| cellular response to reactive oxygen species | |
| cellular response to prostaglandin stimulus | |
| cellular response to jasmonic acid stimulus | |
| cellular response to corticosteroid stimulus | |
| cellular response to calcium ion | |
| cellular response to cadmium ion | |
| response to nutrient | |
| response to prostaglandin stimulus | |
| regulation of steroid biosynthetic process | |
| male gonad development | |
| renal absorption | |
| multicellular organismal macromolecule metabolic process | |
| protein import into nucleus, translocation | |
| steroid metabolic process | |
| oxidation-reduction process | |
| doxorubicin metabolic process | |
| daunorubicin metabolic process | |
| prostaglandin metabolic process |
| Pathway | prostanoid biosynthetic pathway |
|---|
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| parturition | |
| regulation of retinoic acid receptor signaling pathway | |
| positive regulation of protein kinase B signaling cascade | |
| cellular response to starvation | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of reactive oxygen species metabolic process | |
| negative regulation of retinoic acid biosynthetic process | |
| regulation of testosterone biosynthetic process | |
| positive regulation of cell proliferation | |
| positive regulation of cell death | |
| positive regulation of endothelial cell apoptotic process | |
| keratinocyte differentiation | |
| retinal metabolic process | |
| farnesol catabolic process | |
| progesterone metabolic process | |
| testosterone biosynthetic process | |
| progesterone catabolic process | |
| cellular response to reactive oxygen species | |
| cellular response to prostaglandin stimulus | |
| cellular response to jasmonic acid stimulus | |
| cellular response to corticosteroid stimulus | |
| cellular response to calcium ion | |
| cellular response to cadmium ion | |
| response to nutrient | |
| response to prostaglandin stimulus | |
| regulation of steroid biosynthetic process | |
| male gonad development | |
| renal absorption | |
| multicellular organismal macromolecule metabolic process | |
| protein import into nucleus, translocation | |
| steroid metabolic process | |
| oxidation-reduction process | |
| doxorubicin metabolic process | |
| daunorubicin metabolic process | |
| prostaglandin metabolic process | |
| oxidoreductase activity | |
| geranylgeranyl reductase activity | |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | |
| delta4-3-oxosteroid 5beta-reductase activity | |
| phenanthrene 9,10-monooxygenase activity | |
| ketosteroid monooxygenase activity | |
| oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor | |
| ketoreductase activity | |
| prostaglandin-F synthase activity | |
| aldo-keto reductase (NADP) activity | |
| 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity | |
| indanol dehydrogenase activity | |
| retinol dehydrogenase activity | |
| prostaglandin D2 11-ketoreductase activity | |
| 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase (NAD+) activity | |
| dihydrotestosterone 17-beta-dehydrogenase activity | |
| testosterone 17-beta-dehydrogenase (NADP+) activity | |
| androsterone dehydrogenase activity | |
| androsterone dehydrogenase (A-specific) activity | |
| alditol:NADP+ 1-oxidoreductase activity | |
| retinal dehydrogenase activity | |
| prostaglandin F receptor activity | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 8644 |
|---|
| Hugo ID | 386 |
|---|
| Human chromosome position | 10p15-p14 |
|---|
| LocusLink ID | 8644 |
|---|---|
| 105349 | |
| 171516 |
| Alias | DD3 |
|---|---|
| DDX | |
| PGFS | |
| HAKRB | |
| HAKRe | |
| HA1753 | |
| HSD17B5 | |
| hluPGFS | |
| aldo-keto reductase family 1 member C3 | |
| indanol dehydrogenase | |
| prostaglandin F synthase | |
| 3-alpha-HSD type II, brain | |
| dihydrodiol dehydrogenase 3 | |
| dihydrodiol dehydrogenase X | |
| chlordecone reductase homolog HAKRb | |
| testosterone 17-beta-dehydrogenase 5 | |
| type IIb 3-alpha hydroxysteroid dehydrogenase | |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | |
| AW146047 | |
| aldo-keto reductase family 1 member C18 | |
| 20alpha-HSD | |
| 20-alpha-HSD | |
| 20alpha-hydroxysteroid dehydrogenase | |
| 20-alpha-hydroxysteroid dehydrogenase | |
| Akr1c18 | |
| HSD1 | |
| 20 alpha-hydroxysteroid dehydrogenase | |
| aldo-keto reductase family 1, member C18 | |
| KIAA0119 | |
| LOC93037 | |
| LOC88015 | |
| LOC51708 | |
| LOC96424 | |
| LOC171516 | |
| RGD1564865 | |
| hluPGFSs | |
| LOC191574 | |
| OTTHUMP00000018996 | |
| prostaglandin F synthetase | |
| steroid 3-alpha-dehydrogenase | |
| type II 3a-hydroxysteroid dehydrogenase | |
| 2610528B18Rik | |
| 3-alpha hydroxysteroid dehydrogenase type IIb | |
| AKR1C3 | |
| aldo-keto reductase family 1, member C3 | |
| aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | |
| 2610528B18 | |
| Dihydrodiol dehydrogenase, type I | |
| Dihydrodiol dehydrogenase III |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603966 |
|---|
| Unigene ID | Hs.78183 |
|---|---|
| Mm.41337 | |
| Rn.10030 |
| KEGG ID | hsa:8644 |
|---|---|
| mmu:105349 | |
| rno:171516 |
| Swiss-Prot Accession | P42330 |
|---|---|
| B4DKT3 | |
| Q3U538 | |
| Q8K023 | |
| P51652 | |
| A8K2V0 | |
| Q5T2L1 | |
| Q96DJ1 | |
| Q96KI8 | |
| Q99530 | |
| Q9UCX1 | |
| Q9UII3 | |
| Q9UKL9 | |
| Q99N44 | |
| Q498E4 |
| EC Number | 1.1.1.213 |
|---|---|
| 1.1.1.112 | |
| 1.1.1.188 | |
| 1.1.1.63 | |
| 1.1.1.64 | |
| 1.3.1.20 | |
| 1.1.1.149 | |
| 1.-.-.- | |
| 1.1.-.- |
| GO ID | 0047020 |
|---|---|
| 0004032 | |
| 0004033 | |
| 0047026 | |
| 0047023 | |
| 0047787 | |
| 0035410 | |
| 0045550 | |
| 0047718 | |
| 0045703 | |
| 0047086 | |
| 0016655 | |
| 0018636 | |
| 0036131 | |
| 0004958 | |
| 0047017 | |
| 0001758 | |
| 0004745 | |
| 0050327 | |
| 0047045 | |
| 0047115 | |
| 0007186 | |
| 0071276 | |
| 0071277 | |
| 0071384 | |
| 0071395 | |
| 0071379 | |
| 0034614 | |
| 0009267 | |
| 0044597 | |
| 0044598 | |
| 0016488 | |
| 0030216 | |
| 0008584 | |
| 0044259 | |
| 1900053 | |
| 0055114 | |
| 0010942 | |
| 0008284 | |
| 2000353 | |
| 0051897 | |
| 2000379 | |
| 0042448 | |
| 0006693 | |
| 0000060 | |
| 0048385 | |
| 2000224 | |
| 0070293 | |
| 0007584 | |
| 0034694 | |
| 0042574 | |
| 0008202 | |
| 0061370 | |
| 0005737 | |
| 0005622 | |
| 0005634 | |
| 0047006 | |
| 0016491 | |
| 0007567 | |
| 0006709 | |
| 0050810 | |
| 0005829 |
| PIR ID | B57407 |
|---|---|
| I73674 | |
| JC2330 |
| Swiss-Prot ID | AK1C3_HUMAN |
|---|---|
| AKC1H_MOUSE | |
| AKC1H_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Plasma membrane |
| IPI ID | IPI00291483 |
|---|---|
| IPI00118068 | |
| IPI00169481 | |
| IPI00204302 |
| Mouse chromosome position | 13 |
|---|
| Rat chromosome position | 17q12.3 |
|---|
| Homologene ID | 128661 |
|---|
| MGI ID | 2145420 |
|---|
| RGD ID | 708428 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|