| URN | urn:agi-llid:5740 |
|---|---|
| Total Entities | 0 |
| Connectivity | 313 |
| Name | Ptgis |
| Description | prostaglandin I2 (prostacyclin) synthase |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | electron carrier activity |
|---|---|
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| isomerase activity | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| prostaglandin-I synthase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| caveola | |
| integral to membrane | |
| endoplasmic reticulum | |
| nucleus | |
| extracellular space |
| GO Biological Process | positive regulation of peroxisome proliferator activated receptor signaling pathway |
|---|---|
| negative regulation of nitric oxide biosynthetic process | |
| negative regulation of NF-kappaB transcription factor activity | |
| positive regulation of apoptotic process | |
| xenobiotic metabolic process | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| cellular response to interleukin-6 | |
| cellular response to interleukin-1 | |
| cellular response to hypoxia | |
| response to hypoxia | |
| negative regulation of inflammatory response | |
| positive regulation of angiogenesis | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| icosanoid metabolic process | |
| prostaglandin metabolic process |
| Pathway | IL1A Expression Targets |
|---|---|
| prostanoid biosynthetic pathway |
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| positive regulation of peroxisome proliferator activated receptor signaling pathway | |
| negative regulation of nitric oxide biosynthetic process | |
| negative regulation of NF-kappaB transcription factor activity | |
| positive regulation of apoptotic process | |
| xenobiotic metabolic process | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| cellular response to interleukin-6 | |
| cellular response to interleukin-1 | |
| cellular response to hypoxia | |
| response to hypoxia | |
| negative regulation of inflammatory response | |
| positive regulation of angiogenesis | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| icosanoid metabolic process | |
| prostaglandin metabolic process | |
| electron carrier activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| isomerase activity | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| prostaglandin-I synthase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| caveola | |
| integral to membrane | |
| endoplasmic reticulum | |
| nucleus | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5740 |
|---|
| Hugo ID | 9603 |
|---|
| Human chromosome position | 20q13.13 |
|---|
| LocusLink ID | 5740 |
|---|---|
| 19223 | |
| 25527 |
| Alias | CYP8 |
|---|---|
| PGIS | |
| PTGI | |
| CYP8A1 | |
| prostacyclin synthase | |
| prostaglandin I2 synthase | |
| cytochrome P450, family 8, subfamily A, polypeptide 1 | |
| RP23-105M23.1 | |
| prostagladin I2 synthase | |
| Prostacyclin synthase (Prostaglandin I2 synthase) | |
| Prostacyclin synthetase | |
| Prostacyclin synthetase (Prostaglandin I2 synthetase) | |
| prostacycline synthase | |
| prostacycline synthases | |
| prostacycline synthetase | |
| prostacycline synthetases | |
| prostagladin I2 synthases | |
| prostagladin I2 synthetase | |
| prostagladin I2 synthetases | |
| Prostaglandin I2 synthetase | |
| prostaglandin I2 (prostacyclin) synthase | |
| PTGIS | |
| prostaglandin I2 (prostacyclin) synthetase | |
| OTTHUMP00000031777 | |
| cytochrome P450 8A1 | |
| cytochrome P4508A1 | |
| MGC126858 | |
| CYP8A I | |
| OTTMUSP00000001112 | |
| PGI2 synthases | |
| MGC126860 | |
| PGI2 synthetase | |
| P450 (CYP) 8A1 | |
| PGI2 synthase | |
| P4508A1 | |
| P450 8A1 | |
| PGI2 synthetases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601699 |
|---|---|
| 145500 |
| Unigene ID | Hs.302085 |
|---|---|
| Mm.2339 | |
| Rn.73051 |
| KEGG ID | hsa:5740 |
|---|---|
| mmu:19223 | |
| rno:25527 |
| Swiss-Prot Accession | Q16647 |
|---|---|
| A2A5T5 | |
| O35074 | |
| Q62969 | |
| Q3MII8 | |
| Q9HAX2 | |
| Q9HAX3 | |
| Q9HAX4 |
| EC Number | 5.3.99.4 |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0005506 | |
| 0004497 | |
| 0016705 | |
| 0008116 | |
| 0071456 | |
| 0071347 | |
| 0071354 | |
| 0006690 | |
| 0032088 | |
| 0050728 | |
| 0045019 | |
| 0045766 | |
| 0043065 | |
| 0035360 | |
| 0001516 | |
| 0044281 | |
| 0006805 | |
| 0005901 | |
| 0005783 | |
| 0005789 | |
| 0005615 | |
| 0016021 | |
| 0005634 | |
| 0016853 | |
| 0046872 | |
| 0016491 | |
| 0006633 | |
| 0006631 | |
| 0006629 | |
| 0055114 | |
| 0006693 | |
| 0016020 | |
| 0001666 |
| PIR ID | JC2231 |
|---|
| Swiss-Prot ID | PTGIS_HUMAN |
|---|---|
| PTGIS_RAT | |
| PTGIS_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00003411 |
|---|---|
| IPI00210318 | |
| IPI00126498 |
| Mouse chromosome position | 2 |
|---|
| Rat chromosome position | 3q42 |
|---|
| Homologene ID | 37374 |
|---|
| MGI ID | 1097156 |
|---|
| RGD ID | 3438 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|