Elsevier Inc. PGG2 PGG2 ---> PGH2 Ptgs2 Ptgs1 arachidonic acid ---> PGG2 TXA2 PGF2alpha PGI2 PGE2 PGD2 PGH2 arachidonic acid Ptges2 Ptges3 Ptges Tbxas1 Cbr1 Akr1c3 Akr1b1 Akr1a1 Ptgis Ptgds Hpgds thromboxane A2 signaling pathway prostaglandin F2alpha signaling pathway prostaglandin I2 signaling pathway prostaglandin E2 signaling pathway prostaglandin D2 signaling pathway PGH2 ---> PGD2 PGI2 ---> cardiovascular functions PGE2 ---> inflammatory response PGE2 ---> perception of pain PGE2 ---> cardiovascular functions PGE2 ---> immunomodulation TXA2 ---> cardiovascular functions reproduction PGF2alpha ---> reproduction PGD2 ---> inflammatory response PGD2 ---> immunomodulation immunomodulation inflammatory response perception of pain cardiovascular functions PGH2 ---> TXA2 PGH2 ---> PGE2 PGH2 ---> PGF2alpha PGD2 ---> PGF2alpha PGE2 ---> PGF2alpha Fam213b PGH2 ---> PGI2 cyclooxygenase mediated pathway of arachidonic acid metabolism