| URN | urn:agi-llid:6573 |
|---|---|
| Connectivity | 58 |
| Name | Slc19a1 |
| Description | solute carrier family 19 (folate transporter), member 1 |
| Notes | Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[supplied by OMIM] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | folic acid binding |
|---|---|
| folic acid transporter activity | |
| methotrexate transporter activity | |
| reduced folate carrier activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| membrane fraction | |
| basolateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | female pregnancy |
|---|---|
| transport | |
| folic acid transport |
| Ariadne Ontology | Vitamin import |
|---|
| Group | Vitamin import |
|---|---|
| female pregnancy | |
| transport | |
| folic acid transport | |
| folic acid binding | |
| folic acid transporter activity | |
| methotrexate transporter activity | |
| reduced folate carrier activity | |
| membrane | |
| plasma membrane | |
| membrane fraction | |
| basolateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 6573 |
|---|
| Hugo ID | 10937 |
|---|
| Human chromosome position | 21q22.3 |
|---|
| LocusLink ID | 6573 |
|---|---|
| 20509 | |
| 29723 |
| Alias | CHMD |
|---|---|
| FOLT | |
| IFC1 | |
| REFC | |
| RFC1 | |
| folate transporter 1 | |
| RFC | |
| IFC-1 | |
| intestinal folate carrier 1 | |
| placental folate transporter | |
| reduced folate carrier protein | |
| solute carrier family 19 member 1 | |
| RFC-1 | |
| AI323572 | |
| OTTMUSP00000045639 | |
| OTTMUSP00000045641 | |
| reduced folate carrier 1 | |
| intestinal folate carrier protein | |
| MTX1 | |
| MGC93506 | |
| methotrexate carrier 1 | |
| methotrexate carrier 2 | |
| methotrexate carrier 5 | |
| methotrexate carrier 6 | |
| solute carrier family 19, member 1 | |
| solute carrier family 19 (sodium/hydrogen exchanger), member 1 | |
| Folate transporter I | |
| homologue of mutant Chinese hamster cell methotrexate uptake deficiency | |
| human reduced folate carrier | |
| IFC I | |
| Intestinal folate carrier | |
| methotrexate carrier I | |
| reduced folate carrier | |
| RFC carrier | |
| RFC I | |
| RFC transporter | |
| Slc19a I | |
| Slc19a1 | |
| solute carrier family 19 | |
| solute carrier family 19 (folate transporter), member 1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600424 |
|---|
| Mouse chromosome position | 10 41.3 cM |
|---|
| GO ID | 0005542 |
|---|---|
| 0008517 | |
| 0015350 | |
| 0008518 | |
| 0015884 | |
| 0006810 | |
| 0005887 | |
| 0016020 | |
| 0005624 | |
| 0016323 | |
| 0016021 | |
| 0005886 | |
| 0007565 |
| Rat chromosome position | 20p12 |
|---|
| Swiss-Prot Accession | P41440 |
|---|---|
| Q59GP0 | |
| Q9BTX8 | |
| Q9UET3 | |
| P41438 | |
| Q542F3 | |
| O35170 | |
| Q8BKT9 | |
| Q9DCR3 | |
| Q9QUM8 | |
| Q5UD31 | |
| Q5UD32 | |
| Q62866 | |
| Q9QYB9 | |
| Q62450 | |
| Q62451 | |
| B2R7U8 | |
| O00553 | |
| O60227 | |
| Q13026 |
| PIR ID | A53092 |
|---|---|
| I38924 | |
| I52728 |
| Unigene ID | Hs.84190 |
|---|---|
| Mm.265060 | |
| Rn.9042 |
| KEGG ID | hsa:6573 |
|---|---|
| mmu:20509 | |
| rno:29723 |
| Swiss-Prot ID | S19A1_MOUSE |
|---|---|
| S19A1_HUMAN | |
| Q542F3_MOUSE | |
| Q9QUM8_RAT | |
| B2R7U8_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00113966 |
|---|---|
| IPI00227964 | |
| IPI00474196 | |
| IPI00375452 | |
| IPI00569731 | |
| IPI00556340 | |
| IPI00748975 | |
| IPI00789082 | |
| IPI00790970 | |
| IPI00473857 | |
| IPI00655244 | |
| IPI00480772 | |
| IPI00480737 | |
| IPI00209262 |
| Homologene ID | 57139 |
|---|
| RGD ID | 3695 |
|---|
| MGI ID | 103182 |
|---|