| URN | urn:agi-llid:25902 |
|---|---|
| Connectivity | 2 |
| Name | Mthfd1l |
| Description | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
| Notes | One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).[supplied by OMIM] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| ligase activity | |
| protein homodimerization activity | |
| ATP binding | |
| formate-tetrahydrofolate ligase activity |
| GO Cellular Component | mitochondrion |
|---|
| GO Biological Process | metabolic process |
|---|---|
| one-carbon metabolic process | |
| folic acid and derivative metabolic process | |
| tetrahydrofolate metabolic process | |
| folic acid and derivative biosynthetic process | |
| 10-formyltetrahydrofolate biosynthetic process | |
| formate metabolic process |
| Group | catalytic activity |
|---|---|
| metabolic process | |
| one-carbon metabolic process | |
| folic acid and derivative metabolic process | |
| tetrahydrofolate metabolic process | |
| folic acid and derivative biosynthetic process | |
| 10-formyltetrahydrofolate biosynthetic process | |
| formate metabolic process | |
| nucleotide binding | |
| ligase activity | |
| protein homodimerization activity | |
| ATP binding | |
| formate-tetrahydrofolate ligase activity | |
| mitochondrion |
| MedScan ID | 25902 |
|---|
| Hugo ID | 21055 |
|---|
| Human chromosome position | 6q25.1 |
|---|
| LocusLink ID | 25902 |
|---|---|
| 270685 | |
| 361472 |
| Alias | FLJ21145 |
|---|---|
| FTHFSDC1 | |
| MTC1THFS | |
| dJ292B18.2 | |
| RP1-292B18.2 | |
| DKFZp586G1517 | |
| monofunctional C1-tetrahydrofolate synthase, mitochondrial | |
| 10-formyl-THF synthetase | |
| mitochondrial C1-tetrahydrofolate synthase | |
| mitochondrial C1-tetrahydrofolate synthetase | |
| formyltetrahydrofolate synthetase domain containing 1 | |
| AI647056 | |
| 2410004L15Rik | |
| OTTMUSP00000038447 | |
| OTTMUSP00000038449 | |
| 2410004L15 | |
| formyltetrahydrofolate synthase domain containing 1 | |
| formyltetrahydrofolate synthase domain containing I | |
| formyltetrahydrofolate synthetase domain containing I | |
| methylenetetrahydrofolate dehydrogenase (NADP dependent) 1-like | |
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | |
| mthfd1l | |
| OTTHUMP00000017418 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 611427 |
|---|
| Mouse chromosome position | 10 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004329 | |
| 0016874 | |
| 0000166 | |
| 0042803 | |
| 0009396 | |
| 0006760 | |
| 0015942 | |
| 0008152 | |
| 0006730 | |
| 0046653 | |
| 0005739 | |
| 0003824 | |
| 0009257 |
| Rat chromosome position | 1p11 |
|---|
| Swiss-Prot Accession | Q6UB35 |
|---|---|
| Q4VXV2 | |
| Q5JYA1 | |
| Q5JYA3 | |
| Q5JYA4 | |
| Q5JYA5 | |
| Q5JYA8 | |
| Q3V3R1 | |
| Q2TBF3 | |
| Q8WVW0 | |
| Q96HG8 | |
| Q9H789 | |
| Q9UFU8 | |
| Q3TVQ0 | |
| Q3V402 | |
| Q80V98 | |
| Q8CAL0 | |
| Q8K2N5 |
| PIR ID | T17244 |
|---|
| Unigene ID | Hs.591343 |
|---|---|
| Mm.184752 | |
| Rn.18065 |
| KEGG ID | hsa:25902 |
|---|---|
| mmu:270685 | |
| rno:361472 |
| EC Number | 6.3.4.3 |
|---|
| Swiss-Prot ID | C1TM_HUMAN |
|---|---|
| C1TM_MOUSE |
| Cell Localization | Mitochondrion |
|---|
| IPI ID | IPI00552054 |
|---|---|
| IPI00939493 | |
| IPI00875833 | |
| IPI00291646 | |
| IPI00644471 | |
| IPI00647214 | |
| IPI00643937 | |
| IPI00646698 | |
| IPI00644940 | |
| IPI00843850 | |
| IPI00643337 | |
| IPI00874041 | |
| IPI00228113 | |
| IPI00365405 |
| Homologene ID | 56706 |
|---|
| RGD ID | 1307311 |
|---|
| MGI ID | 1924836 |
|---|