| URN | urn:agi-llid:10797 |
|---|---|
| Connectivity | 4 |
| Name | Mthfd2 |
| Description | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| Notes | This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| oxidoreductase activity | |
| phosphate binding | |
| magnesium ion binding | |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
| methenyltetrahydrofolate cyclohydrolase activity |
| GO Cellular Component | mitochondrion |
|---|
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| one-carbon metabolic process | |
| tetrahydrofolate metabolic process | |
| folic acid and derivative biosynthetic process | |
| response to heat |
| Ariadne Ontology | Folate and pterins biosynthesis |
|---|
| Group | Folate and pterins biosynthesis |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| one-carbon metabolic process | |
| tetrahydrofolate metabolic process | |
| folic acid and derivative biosynthetic process | |
| response to heat | |
| hydrolase activity | |
| oxidoreductase activity | |
| phosphate binding | |
| magnesium ion binding | |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
| methenyltetrahydrofolate cyclohydrolase activity | |
| mitochondrion |
| MedScan ID | 10797 |
|---|
| Hugo ID | 7434 |
|---|
| Human chromosome position | 2p13.1 |
|---|
| LocusLink ID | 10797 |
|---|---|
| 17768 | |
| 680308 |
| Alias | NMDMC |
|---|---|
| bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | |
| OTTHUMP00000203020 | |
| NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase | |
| methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase | |
| AW558851 | |
| OTTMUSP00000026807 | |
| methylenetetrahydrofolate dehydrogenase 2 | |
| methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase | |
| 1110019K23 | |
| 1110019K23Rik | |
| Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase | |
| LOC680308 | |
| LOC684490 | |
| methylene tetrahydrofolate dehydrogenase | |
| methylene tetrahydrofolate dehydrogenase (NAD dependent) 2 | |
| methylene tetrahydrofolate dehydrogenase (NAD dependent), methenyltetrahyd | |
| methylene tetrahydrofolate dehydrogenase (NAD+ dependent) 2 | |
| methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahyd | |
| methylene tetrahydrofolate dehydrogenase 2 | |
| methylenetetrahydrofolate dehydrogenase (NAD dependent), methenyltetrahydrofolate cyclohydrolase | |
| methylenetetrahydrofolate dehydrogenase (NADP dependent) 2, methenyltetrahydrofolate cyclohydrolase | |
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | |
| Mthfd2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604887 |
|---|
| Mouse chromosome position | 6 35.15 cM |
|---|
| GO ID | 0016787 |
|---|---|
| 0000287 | |
| 0004477 | |
| 0004487 | |
| 0004488 | |
| 0016491 | |
| 0042301 | |
| 0009396 | |
| 0006730 | |
| 0055114 | |
| 0046653 | |
| 0005739 | |
| 0003824 | |
| 0008152 | |
| 0009408 |
| Rat chromosome position | 4q34 |
|---|
| Swiss-Prot Accession | P13995 |
|---|---|
| Q7Z650 | |
| P18155 | |
| Q3U8E7 | |
| Q53G90 | |
| Q53GV5 | |
| Q53S36 | |
| Q3TMN4 |
| PIR ID | S14902 |
|---|---|
| A33267 |
| Unigene ID | Hs.469030 |
|---|---|
| Mm.443 | |
| Mm.475021 | |
| Rn.11744 |
| KEGG ID | hsa:10797 |
|---|---|
| mmu:17768 | |
| rno:680308 |
| EC Number | 1.5.1.15 |
|---|---|
| 3.5.4.9 |
| Swiss-Prot ID | MTDC_HUMAN |
|---|---|
| MTDC_MOUSE |
| Cell Localization | Mitochondrion |
|---|---|
| Mitochondria |
| IPI ID | IPI00011307 |
|---|---|
| IPI00109824 | |
| IPI00873127 | |
| IPI00743626 | |
| IPI00554213 |
| Homologene ID | 21321 |
|---|
| RGD ID | 1311313 |
|---|
| MGI ID | 1338850 |
|---|