| URN | urn:agi-llid:1757 |
|---|---|
| Connectivity | 7 |
| Name | Sardh |
| Description | sarcosine dehydrogenase |
| Notes | This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | oxidoreductase activity |
|---|---|
| FAD binding | |
| aminomethyltransferase activity | |
| sarcosine dehydrogenase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| mitochondrion | |
| mitochondrial matrix |
| GO Biological Process | oxidation reduction |
|---|---|
| glycine biosynthetic process | |
| glycine catabolic process | |
| choline catabolic process |
| Ariadne Ontology | Ser-Gly metabolism |
|---|
| Group | Ser-Gly metabolism |
|---|---|
| oxidation reduction | |
| glycine biosynthetic process | |
| glycine catabolic process | |
| choline catabolic process | |
| oxidoreductase activity | |
| FAD binding | |
| aminomethyltransferase activity | |
| sarcosine dehydrogenase activity | |
| cytoplasm | |
| mitochondrion | |
| mitochondrial matrix |
| MedScan ID | 1757 |
|---|
| Hugo ID | 10536 |
|---|
| Human chromosome position | 9q33-q34 |
|---|
| LocusLink ID | 1757 |
|---|---|
| 192166 | |
| 114123 |
| Alias | SAR |
|---|---|
| SDH | |
| SARD | |
| DMGDHL1 | |
| FLJ36475 | |
| RP11-317B10.2 | |
| sarcosine dehydrogenase, mitochondrial | |
| BPR-2 | |
| OTTHUMP00000022506 | |
| dimethylglycine dehydrogenase-like 1 | |
| MGC6279 | |
| RP23-171K6.2 | |
| OTTMUSP00000012947 | |
| dimethylglycine dehydrogenase-like I | |
| DMGDHL I | |
| OTTHUMP00000022503 | |
| OTTHUMP00000064625 | |
| sarcosine dehydrogenase | |
| SARDH |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604455 |
|---|---|
| 268900 |
| Mouse chromosome position | 2 |
|---|
| GO ID | 0050660 |
|---|---|
| 0004047 | |
| 0016491 | |
| 0008480 | |
| 0006546 | |
| 0055114 | |
| 0005737 | |
| 0005759 | |
| 0005739 | |
| 0042426 | |
| 0006545 |
| Rat chromosome position | 3p12 |
|---|
| Swiss-Prot Accession | A8K596 |
|---|---|
| Q9UL12 | |
| O95173 | |
| O96023 | |
| Q05BT1 | |
| Q53F87 | |
| Q5SYU9 | |
| Q5SYV1 | |
| Q9UL10 | |
| Q9UL11 | |
| Q3TWI2 | |
| Q99LB7 | |
| Q3TQD9 | |
| Q8BU72 | |
| Q64380 | |
| B2RMR5 | |
| B7ZLT6 | |
| Q5SYV0 | |
| Q9Y280 | |
| Q9Y2Y3 | |
| O88499 |
| Unigene ID | Hs.198003 |
|---|---|
| Mm.278467 | |
| Rn.89832 |
| KEGG ID | hsa:1757 |
|---|---|
| mmu:192166 | |
| rno:114123 |
| EC Number | 1.5.99.1 |
|---|
| Swiss-Prot ID | SARDH_HUMAN |
|---|---|
| SARDH_RAT | |
| SARDH_MOUSE | |
| A8K596_HUMAN | |
| Q3TWI2_MOUSE |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Cytoplasm |
| IPI ID | IPI00034308 |
|---|---|
| IPI00209807 | |
| IPI00136213 | |
| IPI00807391 | |
| IPI00843980 | |
| IPI00514525 | |
| IPI00003579 | |
| IPI00642619 | |
| IPI00409324 | |
| IPI00755156 | |
| IPI00753655 | |
| IPI00751861 | |
| IPI00557713 | |
| IPI00781340 |
| Homologene ID | 5149 |
|---|
| RGD ID | 621125 |
|---|
| MGI ID | 2183102 |
|---|