| URN | urn:agi-llid:8836 |
|---|---|
| Connectivity | 13 |
| Name | Ggh |
| Description | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
| Notes | This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| exopeptidase activity | |
| omega peptidase activity | |
| gamma-glutamyl-peptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| cytosol | |
| lysosome | |
| melanosome |
| GO Biological Process | glutamine metabolic process |
|---|---|
| response to drug | |
| response to ethanol | |
| response to zinc ion | |
| response to insulin stimulus |
| Ariadne Ontology | Folate and pterins biosynthesis |
|---|
| Group | Folate and pterins biosynthesis |
|---|---|
| extracellular region | |
| catalytic activity | |
| glutamine metabolic process | |
| response to drug | |
| response to ethanol | |
| response to zinc ion | |
| response to insulin stimulus | |
| hydrolase activity | |
| peptidase activity | |
| exopeptidase activity | |
| omega peptidase activity | |
| gamma-glutamyl-peptidase activity | |
| extracellular space | |
| cytosol | |
| lysosome | |
| melanosome |
| MedScan ID | 8836 |
|---|
| Hugo ID | 4248 |
|---|
| Human chromosome position | 8q12.3 |
|---|
| LocusLink ID | 8836 |
|---|---|
| 14590 | |
| 25455 |
| Alias | GH |
|---|---|
| gamma-glutamyl hydrolase | |
| conjugase | |
| gamma-Glu-X carboxypeptidase | |
| folylpolygammaglutamyl hydrolase | |
| gamma-GH | |
| RP23-259B18.3 | |
| FGPH | |
| folylpolyglutamate hydrolase | |
| MGC105496 | |
| gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | |
| GGH | |
| LOC667301 | |
| OTTMUSP00000006742 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601509 |
|---|
| Mouse chromosome position | 4 |
|---|
| GO ID | 0008238 |
|---|---|
| 0034722 | |
| 0016787 | |
| 0008242 | |
| 0006541 | |
| 0042493 | |
| 0045471 | |
| 0032868 | |
| 0010043 | |
| 0005829 | |
| 0005576 | |
| 0005615 | |
| 0005764 | |
| 0042470 | |
| 0003824 | |
| 0008233 |
| Rat chromosome position | 5q21 |
|---|
| Swiss-Prot Accession | Q92820 |
|---|---|
| B1AWC1 | |
| Q91XH7 | |
| Q91XP1 | |
| Q9Z0L8 | |
| Q62867 |
| PIR ID | JC6115 |
|---|
| Unigene ID | Hs.78619 |
|---|---|
| Mm.20461 | |
| Rn.10260 |
| KEGG ID | hsa:8836 |
|---|---|
| mmu:14590 | |
| rno:25455 |
| EC Number | 3.4.19.9 |
|---|
| Swiss-Prot ID | GGH_HUMAN |
|---|---|
| GGH_RAT | |
| B1AWC1_MOUSE |
| Cell Localization | Secreted |
|---|---|
| extracellular space | |
| Lysosome | |
| Melanosome | |
| Mitochondria |
| IPI ID | IPI00023728 |
|---|---|
| IPI00209265 | |
| IPI00828662 | |
| IPI00129243 | |
| IPI00322167 | |
| IPI00874295 |
| Homologene ID | 2881 |
|---|
| RGD ID | 2682 |
|---|
| MGI ID | 1329035 |
|---|