| URN | urn:agi-llid:2350 |
|---|---|
| Connectivity | 19 |
| Name | Folr2 |
| Description | folate receptor 2 (fetal) |
| Notes | The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | folic acid binding |
|---|---|
| receptor activity | |
| folic acid transporter activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| plasma membrane | |
| membrane fraction | |
| anchored to membrane |
| GO Biological Process | folic acid transport |
|---|---|
| posttranslational protein targeting to membrane |
| Ariadne Ontology | Folate receptor |
|---|
| Group | Folate receptor |
|---|---|
| extracellular region | |
| folic acid transport | |
| posttranslational protein targeting to membrane | |
| folic acid binding | |
| receptor activity | |
| folic acid transporter activity | |
| membrane | |
| plasma membrane | |
| membrane fraction | |
| anchored to membrane |
| MedScan ID | 2350 |
|---|
| Hugo ID | 3793 |
|---|
| Human chromosome position | 11q13.3-q13.5 |
|---|
| LocusLink ID | 2350 |
|---|---|
| 14276 | |
| 293154 |
| Alias | FR-P3 |
|---|---|
| FR-BETA | |
| BETA-HFR | |
| FBP/PL-1 | |
| folate receptor beta | |
| FBP | |
| folate receptor, beta | |
| folate receptor, fetal/placental | |
| placental folate-binding protein | |
| folate-binding protein, fetal/placental | |
| FBP2 | |
| Folbp2 | |
| Folbp-2 | |
| folate binding protein 2 | |
| folate-binding protein 2 | |
| FBP/PL I | |
| folate binding protein II | |
| folate receptor 2 | |
| folate receptor 2 (fetal) | |
| FOLR2 | |
| Placental folate binding protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 136425 |
|---|
| Mouse chromosome position | 7 |
|---|
| GO ID | 0005542 |
|---|---|
| 0004872 | |
| 0015884 | |
| 0031225 | |
| 0005576 | |
| 0005624 | |
| 0005886 | |
| 0008517 | |
| 0006620 | |
| 0016020 |
| Rat chromosome position | 1q32 |
|---|
| Swiss-Prot Accession | P14207 |
|---|---|
| Q6GTE8 | |
| A0AUM2 | |
| O14596 | |
| Q05CA5 | |
| Q53HP1 | |
| Q05685 |
| PIR ID | A53315 |
|---|---|
| B40969 |
| Unigene ID | Hs.433159 |
|---|---|
| Mm.439666 | |
| Rn.8801 |
| KEGG ID | hsa:2350 |
|---|---|
| mmu:14276 | |
| rno:293154 |
| Swiss-Prot ID | FOLR2_HUMAN |
|---|---|
| FOLR2_MOUSE | |
| Q6GTE8_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00784257 |
|---|---|
| IPI00113158 | |
| IPI00039050 | |
| IPI00371177 |
| Homologene ID | 627 |
|---|
| RGD ID | 1308515 |
|---|
| MGI ID | 95569 |
|---|