| URN | urn:agi-llid:6470 |
|---|---|
| Connectivity | 42 |
| Name | Shmt1 |
| Description | serine hydroxymethyltransferase 1 (soluble) |
| Notes | This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|---|
| folated mediated one carbon metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| amino acid binding | |
| pyridoxal phosphate binding | |
| protein homodimerization activity | |
| methyltransferase activity | |
| glycine hydroxymethyltransferase activity | |
| L-allo-threonine aldolase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| mitochondrion |
| GO Biological Process | one-carbon metabolic process |
|---|---|
| folic acid metabolic process | |
| purine base biosynthetic process | |
| glycine biosynthetic process | |
| glycine biosynthetic process from serine | |
| L-serine catabolic process | |
| glycine metabolic process | |
| L-serine metabolic process | |
| protein tetramerization | |
| protein homotetramerization |
| Ariadne Ontology | Ser-Gly metabolism |
|---|
| Group | Ser-Gly metabolism |
|---|---|
| catalytic activity | |
| one-carbon metabolic process | |
| folic acid metabolic process | |
| purine base biosynthetic process | |
| glycine biosynthetic process | |
| glycine biosynthetic process from serine | |
| L-serine catabolic process | |
| glycine metabolic process | |
| L-serine metabolic process | |
| protein tetramerization | |
| protein homotetramerization | |
| transferase activity | |
| amino acid binding | |
| pyridoxal phosphate binding | |
| protein homodimerization activity | |
| methyltransferase activity | |
| glycine hydroxymethyltransferase activity | |
| L-allo-threonine aldolase activity | |
| cytoplasm | |
| cytosol | |
| mitochondrion |
| MedScan ID | 6470 |
|---|
| Hugo ID | 10850 |
|---|
| Human chromosome position | 17p11.2 |
|---|
| LocusLink ID | 6470 |
|---|---|
| 20425 | |
| 287379 |
| Alias | SHMT |
|---|---|
| CSHMT | |
| MGC15229 | |
| MGC24556 | |
| serine hydroxymethyltransferase, cytosolic | |
| 14 kDa protein | |
| serine methylase | |
| glycine hydroxymethyltransferase | |
| cytoplasmic serine hydroxymethyltransferase | |
| mshmt | |
| C81125 | |
| mshmt1 | |
| mshmt2 | |
| AI324848 | |
| AI385541 | |
| RP23-278I21.7 | |
| OTTMUSP00000008170 | |
| LRRGT00032 | |
| cytosolic Serine hydroxymethyltransferase | |
| Glycine hydroxymethyltransferase 1 | |
| Glycine hydroxymethyltransferase I | |
| mshmt I | |
| serine hydroxymethyl transferase 1 | |
| serine hydroxymethyl transferase 1 (soluble) | |
| serine hydroxymethyl transferase I | |
| serine hydroxymethyltransferase 1 | |
| serine hydroxymethyltransferase 1 (soluble) | |
| serine hydroxymethyltransferase I | |
| Serine methylase 1 | |
| Serine methylase I | |
| SHMT I | |
| SHMT1 | |
| soluble serine hydroxymethyltransferase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 182144 |
|---|
| Mouse chromosome position | 11 |
|---|
| GO ID | 0008732 |
|---|---|
| 0016597 | |
| 0004372 | |
| 0042803 | |
| 0030170 | |
| 0016740 | |
| 0006565 | |
| 0046655 | |
| 0019264 | |
| 0006730 | |
| 0051289 | |
| 0051262 | |
| 0009113 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0003824 | |
| 0008168 | |
| 0006563 | |
| 0006545 | |
| 0006544 |
| Rat chromosome position | 10q22 |
|---|
| Swiss-Prot Accession | P34896 |
|---|---|
| Q53ET7 | |
| Q9UMC8 | |
| Q9UMC9 | |
| Q9UMD0 | |
| Q8R0X9 | |
| P50431 | |
| Q9CWR5 | |
| Q6TXG7 | |
| Q4KLG7 | |
| Q96HY0 | |
| Q9UMD1 | |
| Q9UMD2 |
| PIR ID | A46746 |
|---|
| Unigene ID | Hs.513987 |
|---|---|
| Hs.636044 | |
| Mm.364956 | |
| Rn.3684 |
| KEGG ID | hsa:6470 |
|---|---|
| mmu:20425 | |
| rno:287379 |
| EC Number | 2.1.2.1 |
|---|
| Swiss-Prot ID | GLYC_HUMAN |
|---|---|
| Q6TXG7_RAT | |
| Q8R0X9_MOUSE | |
| Q96HY0_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00002519 |
|---|---|
| IPI00220668 | |
| IPI00220669 | |
| IPI00421364 | |
| IPI00608017 | |
| IPI00008665 | |
| IPI00793862 | |
| IPI00791841 | |
| IPI00796912 | |
| IPI00118059 | |
| IPI00627076 |
| Homologene ID | 3074 |
|---|
| RGD ID | 1312011 |
|---|
| MGI ID | 98299 |
|---|