| URN | urn:agi-llid:4522 |
|---|---|
| Connectivity | 33 |
| Name | Mthfd1 |
| Description | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
| Notes | This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|---|
| folated mediated one carbon metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| hydrolase activity | |
| oxidoreductase activity | |
| ligase activity | |
| ATP binding | |
| formyltetrahydrofolate dehydrogenase activity | |
| methylenetetrahydrofolate dehydrogenase activity | |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
| formate-tetrahydrofolate ligase activity | |
| methenyltetrahydrofolate cyclohydrolase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| mitochondrion |
| GO Biological Process | metabolic process |
|---|---|
| oxidation reduction | |
| one-carbon metabolic process | |
| methionine biosynthetic process | |
| tetrahydrofolate metabolic process | |
| purine nucleotide biosynthetic process | |
| histidine catabolic process | |
| histidine biosynthetic process | |
| folic acid and derivative biosynthetic process | |
| cellular amino acid biosynthetic process | |
| nucleotide metabolic process |
| Ariadne Ontology | Folate and pterins biosynthesis |
|---|
| Group | Folate and pterins biosynthesis |
|---|---|
| catalytic activity | |
| metabolic process | |
| oxidation reduction | |
| one-carbon metabolic process | |
| methionine biosynthetic process | |
| tetrahydrofolate metabolic process | |
| purine nucleotide biosynthetic process | |
| histidine catabolic process | |
| histidine biosynthetic process | |
| folic acid and derivative biosynthetic process | |
| cellular amino acid biosynthetic process | |
| nucleotide metabolic process | |
| nucleotide binding | |
| hydrolase activity | |
| oxidoreductase activity | |
| ligase activity | |
| ATP binding | |
| formyltetrahydrofolate dehydrogenase activity | |
| methylenetetrahydrofolate dehydrogenase activity | |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
| formate-tetrahydrofolate ligase activity | |
| methenyltetrahydrofolate cyclohydrolase activity | |
| cytoplasm | |
| mitochondrion |
| MedScan ID | 4522 |
|---|
| Hugo ID | 7432 |
|---|
| Human chromosome position | 14q24 |
|---|
| LocusLink ID | 4522 |
|---|---|
| 108156 | |
| 64300 |
| Alias | MTHFC |
|---|---|
| MTHFD | |
| C-1-tetrahydrofolate synthase, cytoplasmic | |
| C1-THF synthase | |
| cytoplasmic C-1-tetrahydrofolate synthase | |
| 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase | |
| Dcs | |
| E430024A07Rik | |
| C1-tetrahydrofolate synthase | |
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase | |
| 10-formyltetrahydrofolate synthase | |
| 10-formyltetrahydrofolate synthetase | |
| 5,10-methylenetetrahydrofolate cyclohydrolase | |
| 5,10-methylenetetrahydrofolate dehydrogenase | |
| 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthase | |
| 5,10-methylenetetrahydrofolate:NADP oxidoreductase | |
| C1-tetrahydrofolate synthetase | |
| C-1-tetrahydrofolate synthetase, cytoplasmic | |
| C1-THF synthetase | |
| Citrovorum factor cyclodehydrase | |
| cyclohydrolase | |
| cyclohydrolases | |
| cytoplasmic C-1-tetrahydrofolate synthetase | |
| E430024A07 | |
| formyl-methenyl-methylenetetrahydrofolate synthase | |
| formyl-methenyl-methylenetetrahydrofolate synthases | |
| formyl-methenyl-methylenetetrahydrofolate synthetase | |
| formyl-methenyl-methylenetetrahydrofolate synthetases | |
| formyltetrahydrofolate synthase | |
| formyltetrahydrofolate synthetase | |
| LOC64300 | |
| methenyltetrahydrofolate cyclohydrolase | |
| methylenetetrahydrofolate dehydrogenase | |
| methylenetetrahydrofolate dehydrogenase (NADP dependent) | |
| methylenetetrahydrofolate dehydrogenase (NADP dependent) 1 | |
| methylenetetrahydrofolate dehydrogenase (NADP dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase | |
| methylenetetrahydrofolate dehydrogenase (NADP dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | |
| methylenetetrahydrofolate dehydrogenase (NADP) | |
| methylenetetrahydrofolate dehydrogenase (NADP) 1 | |
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) | |
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 | |
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase | |
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | |
| methylenetetrahydrofolate dehydrogenase 1 | |
| methylenetetrahydrofolate dehydrogenase I | |
| Mthfd I | |
| Mthfd1 | |
| N5,N10-methylenetetrahydrofolate dehydrogenase | |
| NADP-dependent cyclohydrolase/formyltetrahydrofolate synthase | |
| NADP-dependent cyclohydrolase/formyltetrahydrofolate synthetase | |
| NEUT2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 172460 |
|---|---|
| 601634 |
| Mouse chromosome position | 12 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004329 | |
| 0016155 | |
| 0016787 | |
| 0016874 | |
| 0004477 | |
| 0004488 | |
| 0004486 | |
| 0000166 | |
| 0016491 | |
| 0008652 | |
| 0009396 | |
| 0000105 | |
| 0006548 | |
| 0009086 | |
| 0006730 | |
| 0055114 | |
| 0006164 | |
| 0005737 | |
| 0005739 | |
| 0003824 | |
| 0008152 | |
| 0009117 | |
| 0046653 |
| Rat chromosome position | 6q24 |
|---|
| Swiss-Prot Accession | P11586 |
|---|---|
| Q3TW74 | |
| Q8BXX7 | |
| Q8R013 | |
| Q3UZH3 | |
| Q8BY49 | |
| Q922D8 | |
| P27653 | |
| Q5EBC3 | |
| B2R5Y2 | |
| Q86VC9 | |
| Q9BVP5 | |
| Q62808 |
| PIR ID | A31903 |
|---|---|
| A35367 |
| Unigene ID | Hs.652308 |
|---|---|
| Mm.29584 | |
| Rn.1114 |
| KEGG ID | hsa:4522 |
|---|---|
| mmu:108156 | |
| rno:64300 |
| EC Number | 6.3.4.3 |
|---|---|
| 1.5.1.5 | |
| 3.5.4.9 |
| Swiss-Prot ID | C1TC_HUMAN |
|---|---|
| C1TC_RAT | |
| Q3TW74_MOUSE | |
| Q8BXX7_MOUSE | |
| Q8R013_MOUSE | |
| C1TC_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondria |
| IPI ID | IPI00218342 |
|---|---|
| IPI00231356 | |
| IPI00953783 | |
| IPI00122862 |
| Homologene ID | 55940 |
|---|
| RGD ID | 708531 |
|---|
| MGI ID | 1342005 |
|---|