| URN | urn:agi-llid:1719 |
|---|---|
| Connectivity | 191 |
| Name | Dhfr |
| Description | dihydrofolate reductase |
| Notes | Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|---|
| folated mediated one carbon metabolic pathway |
| GO Molecular Function | dihydrofolic acid binding |
|---|---|
| drug binding | |
| oxidoreductase activity | |
| NADP or NADPH binding | |
| dihydrofolate reductase activity |
| GO Cellular Component | soluble fraction |
|---|
| GO Biological Process | oxidation reduction |
|---|---|
| one-carbon metabolic process | |
| dihydrofolate metabolic process | |
| tetrahydrofolate metabolic process | |
| tetrahydrofolate biosynthetic process | |
| glycine biosynthetic process | |
| nucleotide biosynthetic process | |
| response to nicotine | |
| response to methotrexate |
| Ariadne Ontology | Folate and pterins biosynthesis |
|---|
| Group | Folate and pterins biosynthesis |
|---|---|
| oxidation reduction | |
| one-carbon metabolic process | |
| dihydrofolate metabolic process | |
| tetrahydrofolate metabolic process | |
| tetrahydrofolate biosynthetic process | |
| glycine biosynthetic process | |
| nucleotide biosynthetic process | |
| response to nicotine | |
| response to methotrexate | |
| dihydrofolic acid binding | |
| drug binding | |
| oxidoreductase activity | |
| NADP or NADPH binding | |
| dihydrofolate reductase activity | |
| soluble fraction |
| MedScan ID | 1719 |
|---|
| Hugo ID | 2861 |
|---|---|
| 2862 |
| Human chromosome position | 5q11.2-q13.2 |
|---|
| LocusLink ID | 1719 |
|---|---|
| 13361 | |
| 24312 |
| Alias | DYR |
|---|---|
| DHFRP1 | |
| dihydrofolate reductase | |
| AA607882 | |
| AI662710 | |
| AW555094 | |
| 8430436I03Rik | |
| Dhfr1 | |
| Dihydrofolate reductase 1 (active) | |
| DHFR | |
| 7,8-dihydrofolate reductase | |
| 7,8-dihydrofolate reductases | |
| 8430436I03 | |
| Dhfr I | |
| Dihydrofolate reductase 1 | |
| Dihydrofolate reductase I | |
| dihydrofolate reductase:thymidylate synthase | |
| dihydrofolate reductase:thymidylate synthases | |
| dihydrofolate reductase:thymidylate synthetase | |
| dihydrofolate reductase:thymidylate synthetases | |
| dihydrofolic acid reductase | |
| dihydrofolic acid reductases | |
| dihydrofolic reductase | |
| dihydrofolic reductases | |
| folic acid reductase | |
| folic acid reductases | |
| folic reductase | |
| folic reductases | |
| LOC153814 | |
| LOC203373 | |
| NAD(P)H-dihydrofolate reductase | |
| NAD(P)H-dihydrofolate reductases | |
| NADP(H)-dihydrofolate reductase | |
| NADP(H)-dihydrofolate reductases | |
| NADPH-dihydrofolate reductase | |
| NADPH-dihydrofolate reductases | |
| pteridine reductase:dihydrofolate reductase | |
| pteridine reductase:dihydrofolate reductases | |
| tetrahydrofolate dehydrogenase | |
| tetrahydrofolate dehydrogenases | |
| thymidylate synthase-dihydrofolate reductase | |
| thymidylate synthase-dihydrofolate reductases | |
| thymidylate synthetase-dihydrofolate reductase | |
| thymidylate synthetase-dihydrofolate reductases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 126060 |
|---|
| Mouse chromosome position | 13 43.0 cM |
|---|
| GO ID | 0050661 |
|---|---|
| 0004146 | |
| 0051871 | |
| 0016491 | |
| 0046452 | |
| 0006545 | |
| 0009165 | |
| 0006730 | |
| 0055114 | |
| 0031427 | |
| 0046654 | |
| 0005625 | |
| 0008144 | |
| 0035094 | |
| 0046653 |
| Rat chromosome position | 2q12 |
|---|
| Swiss-Prot Accession | B0YJ76 |
|---|---|
| P00374 | |
| P00375 | |
| Q544T5 | |
| B0BMV8 | |
| Q920D2 | |
| Q14130 | |
| Q6IRW8 | |
| P70693 | |
| Q61485 | |
| Q61487 | |
| Q61579 |
| PIR ID | A22551 |
|---|---|
| S13096 |
| Unigene ID | Hs.592364 |
|---|---|
| Hs.648635 | |
| Mm.23695 | |
| Rn.24681 |
| KEGG ID | hsa:1719 |
|---|---|
| mmu:13361 | |
| rno:24312 |
| EC Number | 1.5.1.3 |
|---|
| Swiss-Prot ID | DYR_RAT |
|---|---|
| DYR_HUMAN | |
| DYR_MOUSE | |
| B0YJ76_HUMAN | |
| B0BMV8_RAT | |
| Q544T5_MOUSE |
| Cell Localization | Mitochondria |
|---|
| IPI ID | IPI00200419 |
|---|---|
| IPI00030357 | |
| IPI00230042 |
| Homologene ID | 56470 |
|---|
| RGD ID | 2500 |
|---|
| MGI ID | 94890 |
|---|