| URN | urn:agi-llid:6472 |
|---|---|
| Connectivity | 0 |
| Name | Shmt2 |
| Description | serine hydroxymethyltransferase 2 (mitochondrial) |
| Notes | This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|---|
| folated mediated one carbon metabolic pathway |
| GO Molecular Function | transferase activity |
|---|---|
| amino acid binding | |
| pyridoxal phosphate binding | |
| methyltransferase activity | |
| glycine hydroxymethyltransferase activity | |
| L-allo-threonine aldolase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial inner membrane | |
| mitochondrial nucleoid | |
| mitochondrial intermembrane space | |
| mitochondrial matrix |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| one-carbon metabolic process | |
| glycine biosynthetic process | |
| L-serine biosynthetic process | |
| glycine biosynthetic process from serine | |
| glycine metabolic process | |
| L-serine metabolic process | |
| protein homotetramerization |
| Ariadne Ontology | Ser-Gly metabolism |
|---|
| Group | Ser-Gly metabolism |
|---|---|
| positive regulation of cell proliferation | |
| one-carbon metabolic process | |
| glycine biosynthetic process | |
| L-serine biosynthetic process | |
| glycine biosynthetic process from serine | |
| glycine metabolic process | |
| L-serine metabolic process | |
| protein homotetramerization | |
| transferase activity | |
| amino acid binding | |
| pyridoxal phosphate binding | |
| methyltransferase activity | |
| glycine hydroxymethyltransferase activity | |
| L-allo-threonine aldolase activity | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial nucleoid | |
| mitochondrial intermembrane space | |
| mitochondrial matrix |
| MedScan ID | 6472 |
|---|
| Hugo ID | 10852 |
|---|
| Human chromosome position | 12q12-q14 |
|---|
| LocusLink ID | 6472 |
|---|---|
| 108037 | |
| 299857 |
| Alias | GLYA |
|---|---|
| SHMT | |
| serine hydroxymethyltransferase, mitochondrial | |
| GLY A+ | |
| serine aldolase | |
| serine methylase | |
| threonine aldolase | |
| serine hydroxymethylase | |
| glycine hydroxymethyltransferase | |
| glycine auxotroph A, human complement for hamster | |
| AA408223 | |
| AA986903 | |
| 2700043D08Rik | |
| MGC105820 | |
| 2700043D08 | |
| Glycine hydroxymethyltransferase 2 | |
| Glycine hydroxymethyltransferase II | |
| mitochondrial serine hydroxymethyl transferase 2 | |
| mitochondrial serine hydroxymethyl transferase II | |
| mitochondrial Serine hydroxymethyltransferase | |
| serine hydroxymethyl transferase 2 | |
| serine hydroxymethyl transferase 2 (mitochondrial) | |
| serine hydroxymethyl transferase II | |
| serine hydroxymethyltransferase 2 (mitochondrial) | |
| Serine methylase 2 | |
| Serine methylase II | |
| SHMT2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138450 |
|---|
| Mouse chromosome position | 10 |
|---|
| GO ID | 0004372 |
|---|---|
| 0030170 | |
| 0016740 | |
| 0006563 | |
| 0006544 | |
| 0006730 | |
| 0005759 | |
| 0042645 | |
| 0005739 | |
| 0008732 | |
| 0016597 | |
| 0008168 | |
| 0006564 | |
| 0006545 | |
| 0019264 | |
| 0008284 | |
| 0051289 | |
| 0005743 | |
| 0005758 |
| Rat chromosome position | 7q22 |
|---|
| Swiss-Prot Accession | Q5BJF5 |
|---|---|
| Q8N1A5 | |
| B7Z9F1 | |
| P34897 | |
| Q5HYG8 | |
| B4DJQ3 | |
| Q53ET4 | |
| Q9CZN7 | |
| Q3TFD0 | |
| Q99K87 | |
| Q5U3Z7 | |
| O00740 |
| PIR ID | B46746 |
|---|
| Unigene ID | Hs.75069 |
|---|---|
| Mm.29890 | |
| Rn.9214 |
| KEGG ID | hsa:6472 |
|---|---|
| mmu:108037 | |
| rno:299857 |
| EC Number | 2.1.2.1 |
|---|
| Swiss-Prot ID | GLYM_HUMAN |
|---|---|
| Q8N1A5_HUMAN | |
| Q5U3Z7_RAT | |
| B4DJQ3_HUMAN | |
| Q9CZN7_MOUSE | |
| B7Z9F1_HUMAN | |
| Q5HYG8_HUMAN | |
| Q5BJF5_HUMAN |
| Cell Localization | Mitochondrion |
|---|---|
| Cytoplasm |
| IPI ID | IPI00002520 |
|---|---|
| IPI00795816 | |
| IPI00195109 | |
| IPI00454008 | |
| IPI00789370 | |
| IPI00748411 | |
| IPI00794572 | |
| IPI00386540 | |
| IPI00794549 | |
| IPI00794060 | |
| IPI00794657 | |
| IPI00795324 | |
| IPI00797816 | |
| IPI00797074 | |
| IPI00797146 |
| Homologene ID | 38048 |
|---|
| RGD ID | 1308582 |
|---|
| MGI ID | 1277989 |
|---|