| URN | urn:agi-llid:2348 |
|---|---|
| Connectivity | 96 |
| Name | Folr1 |
| Description | folate receptor 1 (adult) |
| Notes | The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | folic acid binding |
|---|---|
| receptor activity | |
| folic acid transporter activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| plasma membrane | |
| brush border | |
| membrane fraction | |
| anchored to membrane | |
| anchored to plasma membrane | |
| integral to plasma membrane |
| GO Biological Process | cell death |
|---|---|
| receptor-mediated endocytosis | |
| folic acid metabolic process | |
| folic acid transport | |
| posttranslational protein targeting to membrane |
| Ariadne Ontology | Folate receptor |
|---|
| Group | Folate receptor |
|---|---|
| extracellular region | |
| cell death | |
| receptor-mediated endocytosis | |
| folic acid metabolic process | |
| folic acid transport | |
| posttranslational protein targeting to membrane | |
| folic acid binding | |
| receptor activity | |
| folic acid transporter activity | |
| membrane | |
| plasma membrane | |
| brush border | |
| membrane fraction | |
| anchored to membrane | |
| anchored to plasma membrane | |
| integral to plasma membrane |
| MedScan ID | 2348 |
|---|
| Hugo ID | 3791 |
|---|
| Human chromosome position | 11q13.3-q14.1 |
|---|
| LocusLink ID | 2348 |
|---|---|
| 14275 | |
| 171049 |
| Alias | FBP |
|---|---|
| FOLR | |
| folate receptor alpha | |
| FR-alpha | |
| KB cells FBP | |
| folate binding protein | |
| folate receptor, adult | |
| adult folate-binding protein | |
| ovarian tumor-associated antigen MOv18 | |
| FBP1 | |
| Folbp1 | |
| Folbp-1 | |
| OTTMUSP00000025090 | |
| OTTMUSP00000025091 | |
| OTTMUSP00000025092 | |
| OTTMUSP00000025093 | |
| OTTMUSP00000025095 | |
| OTTMUSP00000025098 | |
| OTTMUSP00000025099 | |
| OTTMUSP00000025101 | |
| OTTMUSP00000025105 | |
| folate binding protein 1 | |
| folate-binding protein 1 | |
| 0910001L11Rik | |
| Adult folate binding protein | |
| folate binding protein I | |
| folate receptor | |
| folate receptor (a) | |
| folate receptor [a] | |
| folate receptor 1 | |
| folate receptor 1 (adult) | |
| folate receptor 4 (delta) | |
| folate-binding protein | |
| Folbp I | |
| Folbp3 | |
| FOLR I | |
| FOLR1 | |
| Folr4 | |
| MOv18 | |
| Ovarian tumor- associated antigen MOv18 | |
| Ovarian tumour- associated antigen MOv18 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 136430 |
|---|---|
| 613068 |
| Mouse chromosome position | 7 |
|---|
| GO ID | 0005542 |
|---|---|
| 0004872 | |
| 0008219 | |
| 0046655 | |
| 0015884 | |
| 0006898 | |
| 0046658 | |
| 0005903 | |
| 0005576 | |
| 0005887 | |
| 0005624 | |
| 0005886 | |
| 0008517 | |
| 0006620 | |
| 0031225 | |
| 0016020 |
| Rat chromosome position | 1q32 |
|---|
| Swiss-Prot Accession | P15328 |
|---|---|
| O14597 | |
| Q6LDL1 | |
| Q96QD1 | |
| Q9NP04 | |
| Q9R222 | |
| P35846 | |
| Q8CFX6 | |
| Q9R223 | |
| Q9JL02 | |
| Q53EW2 | |
| Q6FGT8 | |
| Q6LC90 | |
| Q9UCT2 |
| PIR ID | A44904 |
|---|
| Unigene ID | Hs.73769 |
|---|---|
| Mm.2135 | |
| Rn.6912 |
| KEGG ID | hsa:2348 |
|---|---|
| mmu:14275 | |
| rno:171049 |
| Swiss-Prot ID | FOLR1_HUMAN |
|---|---|
| Q9JL02_RAT | |
| Q9R222_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00441498 |
|---|---|
| IPI00202950 | |
| IPI00331283 | |
| IPI00123114 | |
| IPI00831259 | |
| IPI00830684 | |
| IPI00830780 | |
| IPI00830200 | |
| IPI00830304 | |
| IPI00830420 | |
| IPI00830426 | |
| IPI00830531 | |
| IPI00831400 | |
| IPI00831506 |
| Homologene ID | 7322 |
|---|
| RGD ID | 71032 |
|---|
| MGI ID | 95568 |
|---|