| URN | urn:agi-llid:2346 |
|---|---|
| Connectivity | 98 |
| Name | Folh1 |
| Description | folate hydrolase (prostate-specific membrane antigen) 1 |
| Notes | This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq] |
| Pathway | folate cycle metabolic pathway |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| calcium ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| dipeptidase activity | |
| carboxypeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| membrane fraction | |
| integral to plasma membrane |
| GO Biological Process | proteolysis |
|---|
| Group | proteolysis |
|---|---|
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| dipeptidase activity | |
| carboxypeptidase activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| membrane fraction | |
| integral to plasma membrane |
| MedScan ID | 2346 |
|---|
| Hugo ID | 3788 |
|---|
| Human chromosome position | 11p11.2 |
|---|
| LocusLink ID | 2346 |
|---|
| Alias | PSM |
|---|---|
| FGCP | |
| FOLH | |
| GCP2 | |
| PSMA | |
| mGCP | |
| GCPII | |
| NAALAD1 | |
| NAALAdase | |
| GIG27 | |
| glutamate carboxypeptidase 2 | |
| NAALADase I | |
| folate hydrolase 1 | |
| glutamate carboxylase II | |
| glutamate carboxypeptidase II | |
| cell growth-inhibiting protein 27 | |
| prostate-specific membrane antigen | |
| membrane glutamate carboxypeptidase | |
| cell growth-inhibiting gene 27 protein | |
| folylpoly-gamma-glutamate carboxypeptidase | |
| prostate specific membrane antigen variant F | |
| pteroylpoly-gamma-glutamate carboxypeptidase | |
| N-acetylated alpha-linked acidic dipeptidase 1 | |
| N-acetylated-alpha-linked acidic dipeptidase I | |
| folate hydrolase | |
| folate hydrolase (prostate-specific membrane antigen) 1 | |
| folate hydrolase (prostate-specific membrane antigen) I | |
| folate hydrolase 1 (prostate-specific membrane antigen) | |
| folate hydrolase I | |
| Folh I | |
| Folh1 | |
| GCP II | |
| glutamate carboxylase 2 | |
| LOC112734 | |
| LOC93212 | |
| mopsm | |
| Naalad | |
| PCMA | |
| PCM-C | |
| PCM-D | |
| Prostate-specific membrane antigen 1 | |
| prostate-specific membrane antigen homolog | |
| Prostate-specific membrane antigen I |
| Organism | Homo sapiens |
|---|
| OMIM ID | 600934 |
|---|
| GO ID | 0004180 |
|---|---|
| 0016805 | |
| 0046872 | |
| 0008237 | |
| 0008233 | |
| 0006508 | |
| 0005737 | |
| 0005887 | |
| 0016020 | |
| 0005624 | |
| 0005886 | |
| 0005509 | |
| 0008270 |
| Swiss-Prot Accession | Q04609 |
|---|---|
| Q2VPJ0 | |
| Q7Z5D2 | |
| A9CB79 | |
| B7Z343 | |
| O43748 | |
| Q16305 | |
| Q541A4 | |
| Q8TAY3 | |
| Q9NP15 | |
| Q9NYE2 | |
| Q9P1P8 |
| PIR ID | A56881 |
|---|
| Unigene ID | Hs.654487 |
|---|
| KEGG ID | hsa:2346 |
|---|
| EC Number | 3.4.17.21 |
|---|
| Swiss-Prot ID | FOLH1_HUMAN |
|---|---|
| Q541A4_HUMAN | |
| Q8TAY3_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm |
| IPI ID | IPI00028514 |
|---|---|
| IPI00216907 | |
| IPI00216908 | |
| IPI00216909 | |
| IPI00216910 | |
| IPI00411692 | |
| IPI00944595 | |
| IPI00944663 |
| RGD ID | 70963 |
|---|