Ariadne Genomics Inc. 5-methyl-THF Cbl Mtr polyGluTHF ---> monoGluTHF Folh1 uptaken folate ---> Slc25a32 diet/supplement THF 5,10-methylene-THF folate mediated one-carbon metabolic pathway methionine cycle/metabolic pathway homocysteine metabolic pathway mTHF sarcosine ---> 5,10-methylene-THF dimethylglycine ---> 5,10-methylene-THF mSer ---> 5,10-methylene-THF mGly ---> 5,10-methylene-THF mGly GCS CO2 sarcosine mSer dimethylglycine 5,10-methenyl-THF 10-formyl-THF formate PLP/B6 serine serine ---> 5,10-methylene-THF 5,10-methylene-THF <--> THF FAD Mtrr glutamate(s) DHF uptaken folate folate monoGluTHF polyGluTHF Shmt1 DHF ---> THF 10-formyl-THF ---- CO2 monoGluTHF ---> folate 5,10-methenyl-THF ---> 10-formyl-THF Mthfd2l uptaken folate ---> DHF 10-formyl-THF ---> formate 5,10-methylene-THF ---> 5,10-methenyl-THF 5,10-methenyl-THF ---> 5,10-methylene-THF 10-formyl-THF ---> 5,10-methenyl-THF formate ---> 10-formyl-THF 5-methyl-THF ---> THF THF ---> glutamate(s) Ggh glutamate(s) ---> THF Fpgs Slc25a32 Shmt2 diet/supplement ---> polyGluTHF Slc46a1 Sardh 10-formyl-THF ---> THF Mthfd1 Dhfr 5,10-methylene-THF ---> 5-methyl-THF Mthfr folate ---> uptaken folate Slc19a1 Folr2 Folr1 Mthfd1l Aldh1l1 Dmgdh THF ---> 10-formyl-THF Mthfd2 Mtrr ---> Mtr