| URN | urn:agi-llid:817 |
|---|---|
| Connectivity | 16 |
| Name | Camk2d |
| Description | calcium/calmodulin-dependent protein kinase II delta |
| Notes | The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns. |
| Pathway | New Pathway (3) |
|---|---|
| calcium/calmodulin dependent kinase 2 signaling pathway | |
| calcium-calmodulin dependent kinase 2 signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| calmodulin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| calmodulin-dependent protein kinase activity |
| GO Cellular Component | neuromuscular junction |
|---|---|
| plasma membrane | |
| cytoplasm | |
| calcium- and calmodulin-dependent protein kinase complex | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm | |
| nucleus | |
| T-tubule |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| cardiac muscle contraction | |
| regulation of cell growth | |
| G1-S transition of mitotic cell cycle | |
| regulation of G2-M transition of mitotic cell cycle | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| cellular potassium ion homeostasis | |
| response to hypoxia | |
| calcium ion transport |
| Ariadne Ontology | CAMK |
|---|
| Group | CAMK |
|---|---|
| positive regulation of cell proliferation | |
| cardiac muscle contraction | |
| regulation of cell growth | |
| G1-S transition of mitotic cell cycle | |
| regulation of G2-M transition of mitotic cell cycle | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| cellular potassium ion homeostasis | |
| response to hypoxia | |
| calcium ion transport | |
| nucleotide binding | |
| transferase activity | |
| calmodulin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| calmodulin-dependent protein kinase activity | |
| neuromuscular junction | |
| plasma membrane | |
| cytoplasm | |
| calcium- and calmodulin-dependent protein kinase complex | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm | |
| nucleus | |
| T-tubule |
| MedScan ID | 817 |
|---|
| Hugo ID | 1462 |
|---|
| Human chromosome position | 4q26 |
|---|
| LocusLink ID | 817 |
|---|---|
| 108058 | |
| 24246 |
| Alias | CAMKD |
|---|---|
| MGC44911 | |
| DKFZp686I2288 | |
| DKFZp686G23119 | |
| calcium/calmodulin-dependent protein kinase type II subunit delta | |
| OTTHUMP00000163830 | |
| CaMK-II delta subunit | |
| caMK-II subunit delta | |
| CaM-kinase II delta chain | |
| CaM kinase II delta subunit | |
| caM kinase II subunit delta | |
| calcium/calmodulin-dependent protein kinase type II delta chain | |
| calcium/calmodulin-dependent protein kinase (CaM kinase) II delta | |
| KIAA4163 | |
| MGC60852 | |
| mKIAA4163 | |
| [d]-CaMKII | |
| 2810011D23Rik | |
| 8030469K03Rik | |
| CaMK II | |
| OTTMUSP00000027703 | |
| OTTMUSP00000027704 | |
| OTTMUSP00000027705 | |
| OTTMUSP00000027708 | |
| OTTMUSP00000027709 | |
| OTTMUSP00000027710 | |
| CAMK1 | |
| Camk2 | |
| Camki | |
| RATCAMKI | |
| MGC124639 | |
| Ca++/calmodulin-dependent protein kinase 2 delta subunit | |
| Ca++/calmodulin-dependent protein kinase II delta subunit | |
| Ca++/calmodulin-dependent protein kinase II, delta subunit | |
| (d)-CaMKII | |
| 2810011D23 | |
| 8030469K03 | |
| Ca/calmodulin-dependent protein kinase 2 delta subunit | |
| Ca/calmodulin-dependent protein kinase II delta subunit | |
| calcium/calmodulin-dependent protein kinase (CaM kinase) delta | |
| calcium/calmodulin-dependent protein kinase II delta isoform 1 | |
| calcium/calmodulin-dependent protein kinase II delta isoform 2 | |
| calcium/calmodulin-dependent protein kinase II delta isoform 3 | |
| calcium/calmodulin-dependent protein kinase II delta isoform I | |
| calcium/calmodulin-dependent protein kinase II delta isoform II | |
| calcium/calmodulin-dependent protein kinase II delta isoform III | |
| calcium/calmodulin-dependent protein kinase II, delta | |
| CaM- kinase II delta chain | |
| Camk2d | |
| OTTHUMP00000163829 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607708 |
|---|
| Mouse chromosome position | 3 |
|---|
| GO ID | 0005524 |
|---|---|
| 0005516 | |
| 0004683 | |
| 0000166 | |
| 0016740 | |
| 0006468 | |
| 0001558 | |
| 0005954 | |
| 0005829 | |
| 0030666 | |
| 0005654 | |
| 0005886 | |
| 0016301 | |
| 0004672 | |
| 0004674 | |
| 0000082 | |
| 0006816 | |
| 0060048 | |
| 0030007 | |
| 0008284 | |
| 0046777 | |
| 0010389 | |
| 0001666 | |
| 0030315 | |
| 0005737 | |
| 0031594 | |
| 0005634 |
| Rat chromosome position | 2q42-q43 |
|---|
| Swiss-Prot Accession | A8MVS8 |
|---|---|
| Q13557 | |
| Q4G1A8 | |
| Q92991 | |
| Q6PHZ2 | |
| Q8CCM0 | |
| O70459 | |
| Q3V1X9 | |
| Q8C4I3 | |
| Q8C8X9 | |
| P15791 | |
| Q52PK4 | |
| Q59G21 | |
| Q8N553 | |
| Q9UGH6 | |
| Q9UQE9 | |
| Q3UF87 | |
| Q3UQH9 | |
| Q5DTK4 | |
| Q8CAC5 | |
| Q9CZE2 | |
| P97915 | |
| P97916 | |
| Q3B7L0 | |
| Q63904 | |
| Q63905 | |
| Q63906 | |
| Q63907 | |
| Q63908 |
| PIR ID | A34366 |
|---|
| Unigene ID | Hs.144114 |
|---|---|
| Mm.255822 | |
| Rn.87208 |
| KEGG ID | hsa:817 |
|---|---|
| mmu:108058 | |
| rno:24246 |
| EC Number | 2.7.11.17 |
|---|
| Swiss-Prot ID | KCC2D_HUMAN |
|---|---|
| KCC2D_MOUSE | |
| KCC2D_RAT | |
| A8MVS8_HUMAN | |
| Q8CCM0_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00172636 |
|---|---|
| IPI00430291 | |
| IPI00654569 | |
| IPI00827573 | |
| IPI00827606 | |
| IPI00827625 | |
| IPI00827717 | |
| IPI00828139 | |
| IPI00828178 | |
| IPI00112584 | |
| IPI00406790 | |
| IPI00475044 | |
| IPI00828919 | |
| IPI00212226 | |
| IPI00213583 | |
| IPI00231612 | |
| IPI00231613 | |
| IPI00231614 | |
| IPI00480684 | |
| IPI00480796 | |
| IPI00876923 | |
| IPI00857865 | |
| IPI00828081 | |
| IPI00915441 | |
| IPI00459096 | |
| IPI00858128 | |
| IPI00856305 | |
| IPI00858144 | |
| IPI00779028 | |
| IPI00778148 |
| Homologene ID | 55561 |
|---|
| RGD ID | 2263 |
|---|
| MGI ID | 1341265 |
|---|