| URN | urn:agi-llid:94032 |
|---|---|
| Connectivity | 5 |
| Name | Camk2n2 |
| Description | calcium/calmodulin-dependent protein kinase II inhibitor 2 |
| Notes | This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq] |
| Pathway | calcium/calmodulin dependent kinase 2 signaling pathway |
|---|---|
| calcium-calmodulin dependent kinase 2 signaling pathway |
| GO Molecular Function | protein kinase binding |
|---|---|
| kinase activity | |
| protein kinase inhibitor activity | |
| calcium-dependent protein kinase inhibitor activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| nucleus |
| GO Biological Process | regulation of synaptic plasticity |
|---|
| Group | regulation of synaptic plasticity |
|---|---|
| protein kinase binding | |
| kinase activity | |
| protein kinase inhibitor activity | |
| calcium-dependent protein kinase inhibitor activity | |
| cytoplasm | |
| cytosol | |
| nucleus |
| MedScan ID | 94032 |
|---|
| Hugo ID | 24197 |
|---|
| Human chromosome position | 3q27.1 |
|---|
| LocusLink ID | 94032 |
|---|---|
| 73047 | |
| 59314 |
| Alias | CAMKIIN |
|---|---|
| CAM-KIIN | |
| calcium/calmodulin-dependent protein kinase II inhibitor 2 | |
| CaM-KII inhibitory protein | |
| 2900075A18Rik | |
| caM-KIINbeta | |
| 2900075A18 | |
| camk2n2 | |
| LOC59314 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608721 |
|---|
| Mouse chromosome position | 16 |
|---|
| GO ID | 0004860 |
|---|---|
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0008427 | |
| 0016301 | |
| 0019901 | |
| 0048167 |
| Rat chromosome position | 11q23 |
|---|
| Swiss-Prot Accession | Q96S95 |
|---|---|
| B2RXL5 | |
| Q78WH7 | |
| Q9Z2N6 |
| Unigene ID | Hs.585003 |
|---|---|
| Mm.425977 | |
| Rn.42880 |
| KEGG ID | hsa:94032 |
|---|---|
| mmu:73047 | |
| rno:59314 |
| Swiss-Prot ID | CK2N2_RAT |
|---|---|
| CK2N2_HUMAN | |
| CK2N2_MOUSE | |
| B2RXL5_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| cytosol |
| IPI ID | IPI00210058 |
|---|---|
| IPI00045539 | |
| IPI00131245 |
| Homologene ID | 36398 |
|---|
| RGD ID | 708411 |
|---|
| MGI ID | 1920297 |
|---|