| URN | urn:agi-llid:815 |
|---|---|
| Connectivity | 144 |
| Name | Camk2a |
| Description | calcium/calmodulin-dependent protein kinase II alpha |
| Notes | The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] |
| Pathway | New Pathway (3) |
|---|---|
| calcium/calmodulin dependent kinase 2 signaling pathway | |
| calcium-calmodulin dependent kinase 2 signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| calmodulin binding | |
| glutamate receptor binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| calmodulin-dependent protein kinase activity |
| GO Cellular Component | synapse |
|---|---|
| presynaptic membrane | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| calcium- and calmodulin-dependent protein kinase complex | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm | |
| cell junction | |
| dendrite |
| GO Biological Process | regulation of neurotransmitter secretion |
|---|---|
| regulation of neuronal synaptic plasticity | |
| G1-S transition of mitotic cell cycle | |
| positive regulation of NF-kappaB transcription factor activity | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| calcium ion transport | |
| ionotropic glutamate receptor signaling pathway |
| Ariadne Ontology | CAMK |
|---|
| Group | CAMK |
|---|---|
| synapse | |
| regulation of neurotransmitter secretion | |
| regulation of neuronal synaptic plasticity | |
| G1-S transition of mitotic cell cycle | |
| positive regulation of NF-kappaB transcription factor activity | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| calcium ion transport | |
| ionotropic glutamate receptor signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| calmodulin binding | |
| glutamate receptor binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| calmodulin-dependent protein kinase activity | |
| presynaptic membrane | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| calcium- and calmodulin-dependent protein kinase complex | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm | |
| cell junction | |
| dendrite |
| MedScan ID | 815 |
|---|
| Hugo ID | 1460 |
|---|
| Human chromosome position | 5q32 |
|---|
| LocusLink ID | 815 |
|---|---|
| 12322 | |
| 25400 |
| Alias | CAMKA |
|---|---|
| KIAA0968 | |
| calcium/calmodulin-dependent protein kinase type II subunit alpha | |
| CaMKIINalpha | |
| CaMK-II alpha subunit | |
| caMK-II subunit alpha | |
| CaM-kinase II alpha chain | |
| CaM kinase II alpha subunit | |
| caM kinase II subunit alpha | |
| calcium/calmodulin-dependent protein kinase II alpha-B subunit | |
| calcium/calmodulin-dependent protein kinase type II alpha chain | |
| calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha | |
| CaMKII | |
| R74975 | |
| mKIAA0968 | |
| CaMK II | |
| alpha-CaMKII | |
| OTTMUSP00000017498 | |
| OTTMUSP00000017499 | |
| OTTMUSP00000017500 | |
| OTTMUSP00000022295 | |
| PKCCD | |
| PK2CDD | |
| alpha CaM kinase II | |
| Ca2+/calmodulin-dependent protein kinase II alpha | |
| calcium/calmodulin-dependent protein kinase II alpha subunit | |
| Ca/calmodulin-dependent protein kinase 2 alpha | |
| Ca/calmodulin-dependent protein kinase 2A | |
| Ca/calmodulin-dependent protein kinase II alpha | |
| Ca/calmodulin-dependent protein kinase IIA | |
| Ca/CaM-dependent protein kinase 2 alpha | |
| Ca/CaM-dependent protein kinase 2A | |
| Ca/CaM-dependent protein kinase II alpha | |
| Ca/CaM-dependent protein kinase IIA | |
| Ca++/calmodulin-dependent protein kinase 2 alpha | |
| Ca++/calmodulin-dependent protein kinase 2A | |
| Ca++/calmodulin-dependent protein kinase II alpha | |
| Ca++/calmodulin-dependent protein kinase IIA | |
| Ca++/CaM-dependent protein kinase 2 alpha | |
| Ca++/CaM-dependent protein kinase 2A | |
| Ca++/CaM-dependent protein kinase II alpha | |
| Ca++/CaM-dependent protein kinase IIA | |
| Ca2/calmodulin-dependent protein kinase II alpha | |
| Ca2/calmodulin-dependent protein kinase IIA | |
| Ca2/CaM-dependent protein kinase 2 alpha | |
| Ca2/CaM-dependent protein kinase 2A | |
| Ca2/CaM-dependent protein kinase II alpha | |
| Ca2/CaM-dependent protein kinase IIA | |
| Ca2+/calmodulin-dependent protein kinase IIA | |
| Ca2+/CaM-dependent protein kinase 2 alpha | |
| Ca2+/CaM-dependent protein kinase 2A | |
| Ca2+/CaM-dependent protein kinase II alpha | |
| Ca2+/CaM-dependent protein kinase IIA | |
| calcium/calmodulin-dependent kinase IIA | |
| calcium/calmodulin-dependent protein kinase (CaM kinase) alpha | |
| calcium/calmodulin-dependent protein kinase II alpha | |
| calcium/calmodulin-dependent protein kinase IIA isoform 1 | |
| calcium/calmodulin-dependent protein kinase IIA isoform 2 | |
| calcium/calmodulin-dependent protein kinase IIA isoform I | |
| calcium/calmodulin-dependent protein kinase IIA isoform II | |
| CaM kinase II alpha | |
| CAMK2A | |
| CaMKII alpha | |
| CaMK-II alpha | |
| CaM-KIIalpha | |
| KIAA0968 protein; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calmodulin-dependent protein kinase II alpha | |
| LOC291570 | |
| LOC51618 | |
| OTTHUMP00000165787 | |
| OTTHUMP00000165788 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 114078 |
|---|
| Mouse chromosome position | 18 33.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0005516 | |
| 0004683 | |
| 0016301 | |
| 0000166 | |
| 0016740 | |
| 0051092 | |
| 0006468 | |
| 0030054 | |
| 0005829 | |
| 0030666 | |
| 0005654 | |
| 0005886 | |
| 0042734 | |
| 0045202 | |
| 0035254 | |
| 0004672 | |
| 0004674 | |
| 0000082 | |
| 0006816 | |
| 0035235 | |
| 0046777 | |
| 0048168 | |
| 0046928 | |
| 0005954 | |
| 0005737 | |
| 0030425 | |
| 0016020 |
| Rat chromosome position | 18q11 |
|---|
| Swiss-Prot Accession | A8K161 |
|---|---|
| Q8IWE0 | |
| Q7LDD5 | |
| Q9UQM7 | |
| P11798 | |
| Q80TN1 | |
| P11275 | |
| Q924T0 | |
| Q61284 | |
| Q6ZWN4 | |
| Q9UL21 | |
| Q9Y2H4 | |
| Q9Y352 |
| PIR ID | JC6083 |
|---|---|
| S04365 | |
| A30355 |
| Unigene ID | Hs.724403 |
|---|---|
| Mm.131530 | |
| Rn.107499 |
| KEGG ID | hsa:815 |
|---|---|
| mmu:12322 | |
| rno:25400 |
| EC Number | 2.7.11.17 |
|---|
| Swiss-Prot ID | KCC2A_MOUSE |
|---|---|
| KCC2A_RAT | |
| KCC2A_HUMAN | |
| A8K161_HUMAN | |
| Q80TN1_MOUSE | |
| Q8IWE0_HUMAN | |
| Q7LDD5_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Cell junction | |
| synapse | |
| presynaptic cell membrane |
| IPI ID | IPI00230096 |
|---|---|
| IPI00621806 | |
| IPI00192337 | |
| IPI00215715 | |
| IPI00550056 | |
| IPI00420725 | |
| IPI00877169 | |
| IPI00792729 | |
| IPI00874363 | |
| IPI00754301 | |
| IPI00749647 | |
| IPI00830424 | |
| IPI00779826 | |
| IPI00778098 |
| Homologene ID | 56577 |
|---|
| RGD ID | 2261 |
|---|
| MGI ID | 88256 |
|---|