| URN | urn:agi-llid:9759 |
|---|---|
| Connectivity | 239 |
| Name | Hdac4 |
| Description | histone deacetylase 4 |
| Notes | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq] |
| Pathway | calcium/calmodulin dependent kinase 2 signaling pathway |
|---|---|
| calcium-calmodulin dependent kinase 2 signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| transcription repressor activity | |
| transcription activator activity | |
| transcription factor binding | |
| transcription repressor binding | |
| transcription activator binding | |
| DNA binding | |
| histone deacetylase binding | |
| transcription corepressor activity | |
| sequence-specific DNA binding | |
| promoter binding | |
| potassium ion binding | |
| zinc ion binding | |
| protein deacetylase activity | |
| histone deacetylase activity | |
| specific transcriptional repressor activity |
| GO Cellular Component | neuromuscular junction |
|---|---|
| cytoplasm | |
| cytosol | |
| Z disc | |
| A band | |
| sarcomere | |
| actomyosin | |
| histone deacetylase complex | |
| transcriptional repressor complex | |
| nucleus |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| negative regulation of osteoblast differentiation | |
| skeletal system development | |
| nervous system development | |
| regulation of skeletal muscle fiber development | |
| negative regulation of myotube differentiation | |
| regulation of striated muscle cell differentiation | |
| osteoblast development | |
| B cell differentiation | |
| regulation of cardiac muscle contraction by calcium ion signaling | |
| cardiac muscle hypertrophy in response to stress | |
| regulation of transcription | |
| negative regulation of glycolysis | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of protein sumoylation | |
| positive regulation of transcription factor activity | |
| negative regulation of transcription factor activity | |
| B cell activation | |
| transcription | |
| histone deacetylation | |
| peptidyl-lysine deacetylation | |
| histone H3 deacetylation | |
| histone H4 deacetylation | |
| chromatin modification | |
| chromatin remodeling | |
| response to drug | |
| response to interleukin-1 | |
| inflammatory response | |
| response to denervation involved in regulation of muscle adaptation | |
| regulation of protein binding |
| Ariadne Ontology | Chromatin remodeling |
|---|
| Group | Chromatin remodeling |
|---|---|
| negative regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| negative regulation of osteoblast differentiation | |
| skeletal system development | |
| nervous system development | |
| regulation of skeletal muscle fiber development | |
| negative regulation of myotube differentiation | |
| regulation of striated muscle cell differentiation | |
| osteoblast development | |
| B cell differentiation | |
| regulation of cardiac muscle contraction by calcium ion signaling | |
| cardiac muscle hypertrophy in response to stress | |
| regulation of transcription | |
| negative regulation of glycolysis | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of protein sumoylation | |
| positive regulation of transcription factor activity | |
| negative regulation of transcription factor activity | |
| B cell activation | |
| transcription | |
| histone deacetylation | |
| peptidyl-lysine deacetylation | |
| histone H3 deacetylation | |
| histone H4 deacetylation | |
| chromatin modification | |
| chromatin remodeling | |
| response to drug | |
| response to interleukin-1 | |
| inflammatory response | |
| response to denervation involved in regulation of muscle adaptation | |
| regulation of protein binding | |
| hydrolase activity | |
| transcription repressor activity | |
| transcription activator activity | |
| transcription factor binding | |
| transcription repressor binding | |
| transcription activator binding | |
| DNA binding | |
| histone deacetylase binding | |
| transcription corepressor activity | |
| sequence-specific DNA binding | |
| promoter binding | |
| potassium ion binding | |
| zinc ion binding | |
| protein deacetylase activity | |
| histone deacetylase activity | |
| specific transcriptional repressor activity | |
| neuromuscular junction | |
| cytoplasm | |
| cytosol | |
| Z disc | |
| A band | |
| sarcomere | |
| actomyosin | |
| histone deacetylase complex | |
| transcriptional repressor complex | |
| nucleus |
| MedScan ID | 9759 |
|---|
| Hugo ID | 14063 |
|---|
| Human chromosome position | 2q37.3 |
|---|
| LocusLink ID | 9759 |
|---|---|
| 208727 | |
| 363287 |
| Alias | HD4 |
|---|---|
| HDACA | |
| HA6116 | |
| HDAC-A | |
| KIAA0288 | |
| histone deacetylase 4 | |
| histone deacetylase A | |
| AI047285 | |
| 4932408F19Rik | |
| 4932408F19 | |
| HDAC4 | |
| histone deacetylase IV | |
| LOC727809 | |
| LOC731622 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605314 |
|---|
| Mouse chromosome position | 1 |
|---|
| GO ID | 0004407 |
|---|---|
| 0042826 | |
| 0016787 | |
| 0030955 | |
| 0010843 | |
| 0033558 | |
| 0043565 | |
| 0016566 | |
| 0016563 | |
| 0033613 | |
| 0003714 | |
| 0008134 | |
| 0016564 | |
| 0070491 | |
| 0008270 | |
| 0042113 | |
| 0030183 | |
| 0014898 | |
| 0006338 | |
| 0070932 | |
| 0070933 | |
| 0016575 | |
| 0006954 | |
| 0008285 | |
| 0010553 | |
| 0045820 | |
| 0010832 | |
| 0045668 | |
| 0043433 | |
| 0000122 | |
| 0007399 | |
| 0002076 | |
| 0034983 | |
| 0008284 | |
| 0010552 | |
| 0033235 | |
| 0051091 | |
| 0010882 | |
| 0043393 | |
| 0048742 | |
| 0045449 | |
| 0014894 | |
| 0042493 | |
| 0070555 | |
| 0001501 | |
| 0031672 | |
| 0030018 | |
| 0042641 | |
| 0005737 | |
| 0005829 | |
| 0000118 | |
| 0031594 | |
| 0005634 | |
| 0017053 | |
| 0003677 | |
| 0016568 | |
| 0045892 | |
| 0051153 | |
| 0006350 | |
| 0030017 |
| Rat chromosome position | 9q36 |
|---|
| Swiss-Prot Accession | P56524 |
|---|---|
| Q86YH7 | |
| Q53SB4 | |
| Q53SM2 | |
| Q6NZM9 | |
| Q3TNU8 | |
| Q99P99 | |
| Q3TRZ9 | |
| Q3U2J3 | |
| Q3V3Y4 | |
| Q9UND6 |
| Unigene ID | Hs.20516 |
|---|---|
| Mm.318567 | |
| Rn.223109 |
| KEGG ID | hsa:9759 |
|---|---|
| mmu:208727 | |
| rno:363287 |
| EC Number | 3.5.1.98 |
|---|
| Swiss-Prot ID | HDAC4_MOUSE |
|---|---|
| HDAC4_HUMAN | |
| Q86YH7_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00411004 |
|---|---|
| IPI00466540 | |
| IPI00010088 | |
| IPI00892542 | |
| IPI00892631 | |
| IPI00892764 | |
| IPI00894354 | |
| IPI00894491 | |
| IPI00652439 | |
| IPI00367142 |
| Homologene ID | 55946 |
|---|
| RGD ID | 619979 |
|---|
| MGI ID | 3036234 |
|---|