| URN | urn:agi-llid:816 |
|---|---|
| Connectivity | 57 |
| Name | Camk2b |
| Description | calcium/calmodulin-dependent protein kinase II beta |
| Notes | The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq] |
| Pathway | New Pathway (3) |
|---|---|
| calcium/calmodulin dependent kinase 2 signaling pathway | |
| calcium-calmodulin dependent kinase 2 signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| calmodulin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| calmodulin-dependent protein kinase activity |
| GO Cellular Component | plasma membrane |
|---|---|
| calcium- and calmodulin-dependent protein kinase complex | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm |
| GO Biological Process | signal transduction |
|---|---|
| G1-S transition of mitotic cell cycle | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| calcium ion transport |
| Ariadne Ontology | CAMK |
|---|
| Group | CAMK |
|---|---|
| signal transduction | |
| G1-S transition of mitotic cell cycle | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| calcium ion transport | |
| nucleotide binding | |
| transferase activity | |
| calmodulin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| calmodulin-dependent protein kinase activity | |
| plasma membrane | |
| calcium- and calmodulin-dependent protein kinase complex | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm |
| MedScan ID | 816 |
|---|
| Hugo ID | 1461 |
|---|
| Human chromosome position | 22q12 |
|---|
| LocusLink ID | 816 |
|---|---|
| 12323 | |
| 24245 |
| Alias | CAM2 |
|---|---|
| CAMK2 | |
| CAMKB | |
| MGC29528 | |
| calcium/calmodulin-dependent protein kinase type II subunit beta | |
| OTTHUMP00000159355 | |
| OTTHUMP00000159356 | |
| OTTHUMP00000209344 | |
| caMK-II subunit beta | |
| CaM-kinase II beta chain | |
| CaM kinase II beta subunit | |
| caM kinase II subunit beta | |
| proline rich calmodulin-dependent protein kinase | |
| calcium/calmodulin-dependent protein kinase type II beta chain | |
| Camk2d | |
| MGC90738 | |
| RP23-340E18.5 | |
| CaMK II | |
| OTTMUSP00000005321 | |
| OTTMUSP00000005323 | |
| OTTMUSP00000005326 | |
| calcium/calmodulin-dependent protein kinase II, delta | |
| Ck2b | |
| Ca++/calmodulin-dependent protein kinase II beta subunit | |
| calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | |
| Ca/calmodulin-dependent protein kinase II | |
| Ca/calmodulin-dependent protein kinase II beta subunit | |
| Ca++/calmodulin-dependent protein kinase II | |
| Ca2/calmodulin-dependent protein kinase II beta | |
| Ca2+/calmodulin-dependent protein kinase II beta | |
| calcium/calmodulin-dependent kinase IIB | |
| calcium/calmodulin-dependent protein kinase (CaM kinase) beta | |
| calcium/calmodulin-dependent protein kinase beta | |
| calcium/calmodulin-dependent protein kinase II beta subunit | |
| calcium/calmodulin-dependent protein kinase II, beta | |
| calcium/calmodulin-dependent protein kinase IIB isoform 1 | |
| calcium/calmodulin-dependent protein kinase IIB isoform 2 | |
| calcium/calmodulin-dependent protein kinase IIB isoform 3 | |
| calcium/calmodulin-dependent protein kinase IIB isoform 4 | |
| calcium/calmodulin-dependent protein kinase IIB isoform 5 | |
| calcium/calmodulin-dependent protein kinase IIB isoform 6 | |
| calcium/calmodulin-dependent protein kinase IIB isoform 7 | |
| calcium/calmodulin-dependent protein kinase IIB isoform 8 | |
| calcium/calmodulin-dependent protein kinase IIB isoform I | |
| calcium/calmodulin-dependent protein kinase IIB isoform II | |
| calcium/calmodulin-dependent protein kinase IIB isoform III | |
| calcium/calmodulin-dependent protein kinase IIB isoform IV | |
| calcium/calmodulin-dependent protein kinase IIB isoform V | |
| calcium/calmodulin-dependent protein kinase IIB isoform VI | |
| calcium/calmodulin-dependent protein kinase IIB isoform VII | |
| calcium/calmodulin-dependent protein kinase IIB isoform VIII | |
| CaM- kinase II beta chain | |
| CAM2 beta | |
| Camk2b | |
| CaMKII beta | |
| CaMK-II beta | |
| CaMK-II beta subunit |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607707 |
|---|
| Mouse chromosome position | 11 0.5 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0005516 | |
| 0004683 | |
| 0000166 | |
| 0016740 | |
| 0000082 | |
| 0006816 | |
| 0046777 | |
| 0006468 | |
| 0007165 | |
| 0005829 | |
| 0030666 | |
| 0005654 | |
| 0005886 | |
| 0016301 | |
| 0004672 | |
| 0004674 | |
| 0005954 |
| Rat chromosome position | 14q21 |
|---|
| PIR ID | A45025 |
|---|---|
| A26464 | |
| S68470 |
| Unigene ID | Hs.351887 |
|---|---|
| Mm.439733 | |
| Rn.9743 |
| KEGG ID | hsa:816 |
|---|---|
| mmu:12323 | |
| rno:24245 |
| EC Number | 2.7.11.17 |
|---|
| Swiss-Prot ID | KCC2B_MOUSE |
|---|---|
| KCC2B_HUMAN | |
| KCC2B_RAT | |
| A4D2J9_HUMAN | |
| Q63094_RAT | |
| A4D2K5_HUMAN | |
| Q68EG2_MOUSE | |
| A4D2K0_HUMAN | |
| A4D2K3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00474502 |
|---|---|
| IPI00182944 | |
| IPI00183066 | |
| IPI00219165 | |
| IPI00219166 | |
| IPI00221305 | |
| IPI00298090 | |
| IPI00334271 | |
| IPI00211185 | |
| IPI00326171 | |
| IPI00377174 | |
| IPI00470962 | |
| IPI00745560 | |
| IPI00875723 | |
| IPI00515172 | |
| IPI00649296 | |
| IPI00624499 | |
| IPI00515669 | |
| IPI00649778 | |
| IPI00475302 | |
| IPI00648630 | |
| IPI00209824 | |
| IPI00568840 | |
| IPI00777454 | |
| IPI00781597 | |
| IPI00765054 |
| Homologene ID | 111050 |
|---|
| RGD ID | 2262 |
|---|
| MGI ID | 88257 |
|---|