| URN | urn:agi-llid:2904 |
|---|---|
| Connectivity | 256 |
| Name | Grin2b |
| Description | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| Notes | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq] |
| Pathway | reelin signaling pathway |
|---|---|
| Reelin signaling pathway | |
| Reelin signaling pathway | |
| calcium/calmodulin dependent kinase 2 signaling pathway | |
| calcium-calmodulin dependent kinase 2 signaling pathway |
| GO Molecular Function | transporter activity |
|---|---|
| drug binding | |
| neurotransmitter binding | |
| beta-catenin binding | |
| cell adhesion molecule binding | |
| receptor binding | |
| glutamate receptor binding | |
| protein heterodimerization activity | |
| ionotropic glutamate receptor binding | |
| D2 dopamine receptor binding | |
| glycine binding | |
| metal ion binding | |
| magnesium ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| receptor activity | |
| ionotropic glutamate receptor activity | |
| N-methyl-D-aspartate selective glutamate receptor activity | |
| ion channel activity | |
| cation channel activity | |
| calcium channel activity | |
| extracellular-glutamate-gated ion channel activity |
| GO Cellular Component | synapse |
|---|---|
| presynaptic membrane | |
| postsynaptic membrane | |
| postsynaptic density | |
| synaptic vesicle | |
| synaptic cleft | |
| membrane | |
| plasma membrane | |
| outer membrane-bounded periplasmic space | |
| neuron projection | |
| dendritic spine | |
| Z disc | |
| membrane fraction | |
| synaptosome | |
| flotillin complex | |
| cell junction | |
| integral to membrane | |
| integral to plasma membrane | |
| N-methyl-D-aspartate selective glutamate receptor complex | |
| terminal button |
| GO Biological Process | rhythmic process |
|---|---|
| embryonic development | |
| multicellular organismal response to stress | |
| response to other organism | |
| transport | |
| suckling behavior | |
| cerebral cortex development | |
| hippocampus development | |
| sensory organ development | |
| in utero embryonic development | |
| fear response | |
| positive regulation of synaptic transmission | |
| regulation of synaptic plasticity | |
| regulation of neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| learning or memory | |
| startle response | |
| memory | |
| learning | |
| associative learning | |
| long-term memory | |
| behavioral response to pain | |
| behavioral fear response | |
| positive regulation of cell death | |
| positive regulation of glutamate secretion | |
| synaptic transmission | |
| regulation of MAPKKK cascade | |
| cellular response to magnesium starvation | |
| receptor clustering | |
| regulation of action potential | |
| regulation of postsynaptic membrane potential | |
| regulation of excitatory postsynaptic membrane potential | |
| cellular response to growth factor stimulus | |
| cellular response to lipid | |
| cellular response to dsRNA | |
| cellular response to protein stimulus | |
| cellular response to organic cyclic substance | |
| cellular response to amino acid stimulus | |
| cellular response to manganese ion | |
| response to mechanical stimulus | |
| response to electrical stimulus | |
| response to acid | |
| response to fungicide | |
| response to organic cyclic substance | |
| response to methylmercury | |
| response to carbohydrate stimulus | |
| response to ethanol | |
| response to cytokine stimulus | |
| response to magnesium ion | |
| response to manganese ion | |
| response to calcium ion | |
| response to cocaine | |
| response to amine stimulus | |
| response to growth hormone stimulus | |
| response to amphetamine | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| ion transport | |
| cation transport | |
| calcium ion transport | |
| glutamate signaling pathway | |
| ionotropic glutamate receptor signaling pathway |
| Group | synapse |
|---|---|
| transporter activity | |
| rhythmic process | |
| embryonic development | |
| multicellular organismal response to stress | |
| response to other organism | |
| transport | |
| suckling behavior | |
| cerebral cortex development | |
| hippocampus development | |
| sensory organ development | |
| in utero embryonic development | |
| fear response | |
| positive regulation of synaptic transmission | |
| regulation of synaptic plasticity | |
| regulation of neuronal synaptic plasticity | |
| regulation of long-term neuronal synaptic plasticity | |
| learning or memory | |
| startle response | |
| memory | |
| learning | |
| associative learning | |
| long-term memory | |
| behavioral response to pain | |
| behavioral fear response | |
| positive regulation of cell death | |
| positive regulation of glutamate secretion | |
| synaptic transmission | |
| regulation of MAPKKK cascade | |
| cellular response to magnesium starvation | |
| receptor clustering | |
| regulation of action potential | |
| regulation of postsynaptic membrane potential | |
| regulation of excitatory postsynaptic membrane potential | |
| cellular response to growth factor stimulus | |
| cellular response to lipid | |
| cellular response to dsRNA | |
| cellular response to protein stimulus | |
| cellular response to organic cyclic substance | |
| cellular response to amino acid stimulus | |
| cellular response to manganese ion | |
| response to mechanical stimulus | |
| response to electrical stimulus | |
| response to acid | |
| response to fungicide | |
| response to organic cyclic substance | |
| response to methylmercury | |
| response to carbohydrate stimulus | |
| response to ethanol | |
| response to cytokine stimulus | |
| response to magnesium ion | |
| response to manganese ion | |
| response to calcium ion | |
| response to cocaine | |
| response to amine stimulus | |
| response to growth hormone stimulus | |
| response to amphetamine | |
| detection of mechanical stimulus involved in sensory perception of pain | |
| ion transport | |
| cation transport | |
| calcium ion transport | |
| glutamate signaling pathway | |
| ionotropic glutamate receptor signaling pathway | |
| drug binding | |
| neurotransmitter binding | |
| beta-catenin binding | |
| cell adhesion molecule binding | |
| receptor binding | |
| glutamate receptor binding | |
| protein heterodimerization activity | |
| ionotropic glutamate receptor binding | |
| D2 dopamine receptor binding | |
| glycine binding | |
| metal ion binding | |
| magnesium ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| receptor activity | |
| ionotropic glutamate receptor activity | |
| N-methyl-D-aspartate selective glutamate receptor activity | |
| ion channel activity | |
| cation channel activity | |
| calcium channel activity | |
| extracellular-glutamate-gated ion channel activity | |
| presynaptic membrane | |
| postsynaptic membrane | |
| postsynaptic density | |
| synaptic vesicle | |
| synaptic cleft | |
| membrane | |
| plasma membrane | |
| outer membrane-bounded periplasmic space | |
| neuron projection | |
| dendritic spine | |
| Z disc | |
| membrane fraction | |
| synaptosome | |
| flotillin complex | |
| cell junction | |
| integral to membrane | |
| integral to plasma membrane | |
| N-methyl-D-aspartate selective glutamate receptor complex | |
| terminal button |
| MedScan ID | 2904 |
|---|
| Hugo ID | 4586 |
|---|
| Human chromosome position | 12p12 |
|---|
| LocusLink ID | 2904 |
|---|---|
| 14812 | |
| 24410 |
| Alias | NR2B |
|---|---|
| hNR3 | |
| NMDAR2B | |
| MGC142178 | |
| MGC142180 | |
| glutamate [NMDA] receptor subunit epsilon-2 | |
| NR3 | |
| glutamate receptor subunit epsilon-2 | |
| N-methyl-D-aspartate receptor subunit 3 | |
| N-methyl D-aspartate receptor subtype 2B | |
| AW490526 | |
| GluRepsilon2 | |
| OTTMUSP00000017581 | |
| N-methyl D-aspartate receptor 2B | |
| glutamate receptor, ionotropic, NMDA2B | |
| Glutamate (NMDA) receptor subunit epsilon 2 | |
| glutamate receptor, ionotropic, NMDA2B (epsilon 2) | |
| glutamate receptor, ionotropic, N-methyl D-aspartate 2B | |
| Grin2b | |
| NMDA receptor subtype 2B | |
| NMDA2B | |
| N-methyl D- aspartate receptor subtype 2B | |
| N-methyl-D- aspartate receptor subunit 3 | |
| N-methyl-D- aspartate receptor subunit III | |
| N-methyl-D-aspartate receptor subunit 2B | |
| N-methyl-D-aspartate receptor subunit 2B precursor | |
| Glutamate (NMDA) receptor subunit epsilon 2 precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138252 |
|---|
| Mouse chromosome position | 6 64.5 cM |
|---|
| GO ID | 0031749 |
|---|---|
| 0004972 | |
| 0005262 | |
| 0050839 | |
| 0005234 | |
| 0016594 | |
| 0046872 | |
| 0042165 | |
| 0046982 | |
| 0004872 | |
| 0005102 | |
| 0005215 | |
| 0008270 | |
| 0008306 | |
| 0001662 | |
| 0048266 | |
| 0006816 | |
| 0006812 | |
| 0050966 | |
| 0009790 | |
| 0007215 | |
| 0001701 | |
| 0035235 | |
| 0007611 | |
| 0007613 | |
| 0014049 | |
| 0043408 | |
| 0001508 | |
| 0060079 | |
| 0048169 | |
| 0048167 | |
| 0045471 | |
| 0048511 | |
| 0007423 | |
| 0001964 | |
| 0001967 | |
| 0007268 | |
| 0006810 | |
| 0017146 | |
| 0030018 | |
| 0030054 | |
| 0043197 | |
| 0005887 | |
| 0043005 | |
| 0030288 | |
| 0005886 | |
| 0014069 | |
| 0045211 | |
| 0042734 | |
| 0045202 | |
| 0043083 | |
| 0008021 | |
| 0019717 | |
| 0005261 | |
| 0035254 | |
| 0005216 | |
| 0004970 | |
| 0071445 | |
| 0042596 | |
| 0006811 | |
| 0007612 | |
| 0010942 | |
| 0050806 | |
| 0048168 | |
| 0060078 | |
| 0016600 | |
| 0016021 | |
| 0016020 | |
| 0005624 | |
| 0043195 | |
| 0008013 | |
| 0008144 | |
| 0035255 | |
| 0071230 | |
| 0071359 | |
| 0071363 | |
| 0071396 | |
| 0010350 | |
| 0071287 | |
| 0071407 | |
| 0021987 | |
| 0021766 | |
| 0007616 | |
| 0033555 | |
| 0043113 | |
| 0001101 | |
| 0014075 | |
| 0001975 | |
| 0051592 | |
| 0009743 | |
| 0042220 | |
| 0034097 | |
| 0051602 | |
| 0060992 | |
| 0060416 | |
| 0032026 | |
| 0010042 | |
| 0009612 | |
| 0051597 | |
| 0014070 | |
| 0051707 | |
| 0005509 | |
| 0000287 | |
| 0005515 |
| Rat chromosome position | 4q43 |
|---|
| Swiss-Prot Accession | Q13224 |
|---|---|
| Q59HA9 | |
| Q01097 | |
| Q3TR00 | |
| Q8CG67 | |
| Q8CG68 | |
| Q8CG69 | |
| Q00960 | |
| Q9DCB2 | |
| Q62684 | |
| Q12919 | |
| Q13220 | |
| Q13225 | |
| Q14CU4 | |
| Q9UM56 |
| PIR ID | I49704 |
|---|---|
| B43274 | |
| I39066 | |
| S52086 |
| Unigene ID | Hs.654430 |
|---|---|
| Mm.436649 | |
| Rn.9711 |
| KEGG ID | hsa:2904 |
|---|---|
| mmu:14812 | |
| rno:24410 |
| Swiss-Prot ID | NMDE2_MOUSE |
|---|---|
| NMDE2_RAT | |
| NMDE2_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| postsynaptic cell membrane |
| IPI ID | IPI00321320 |
|---|---|
| IPI00326061 | |
| IPI00297933 | |
| IPI00653592 | |
| IPI00607077 | |
| IPI00655211 |
| Homologene ID | 646 |
|---|
| RGD ID | 2738 |
|---|
| MGI ID | 95821 |
|---|