| URN | urn:agi-llid:775 |
|---|---|
| Connectivity | 170 |
| Name | Cacna1c |
| Description | calcium channel, voltage-dependent, L type, alpha 1C subunit |
| Notes | This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq] |
| Pathway | calcium/calmodulin dependent kinase 2 signaling pathway |
|---|---|
| calcium-calmodulin dependent kinase 2 signaling pathway |
| GO Molecular Function | protein domain specific binding |
|---|---|
| calmodulin binding | |
| protein phosphatase 2A binding | |
| calcium ion binding | |
| ion channel activity | |
| voltage-gated ion channel activity | |
| calcium channel activity | |
| voltage-gated calcium channel activity | |
| dihydropyridine-sensitive calcium channel activity |
| GO Cellular Component | presynaptic membrane |
|---|---|
| postsynaptic density | |
| membrane | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| dendritic shaft | |
| Z disc | |
| nucleus | |
| membrane fraction | |
| caveolar macromolecular signaling complex | |
| T-tubule | |
| voltage-gated calcium channel complex | |
| integral to membrane | |
| dendrite | |
| sarcolemma |
| GO Biological Process | transmembrane transport |
|---|---|
| transport | |
| visual learning | |
| regulation of vasoconstriction | |
| smooth muscle contraction | |
| smooth muscle contraction involved in micturition | |
| adult walking behavior | |
| synaptic transmission | |
| regulation of calcium ion transport via voltage-gated calcium channel activity | |
| calcium ion-dependent exocytosis | |
| growth hormone secretion | |
| insulin secretion | |
| calcium ion transmembrane transport | |
| cellular calcium ion homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| calcium ion transport into cytosol | |
| regulation of organ growth | |
| ion transport | |
| calcium ion transport | |
| regulation of blood pressure | |
| glucose homeostasis |
| Ariadne Ontology | Voltage-dependent Ca++ import |
|---|
| Group | Voltage-dependent Ca++ import |
|---|---|
| transmembrane transport | |
| transport | |
| visual learning | |
| regulation of vasoconstriction | |
| smooth muscle contraction | |
| smooth muscle contraction involved in micturition | |
| adult walking behavior | |
| synaptic transmission | |
| regulation of calcium ion transport via voltage-gated calcium channel activity | |
| calcium ion-dependent exocytosis | |
| growth hormone secretion | |
| insulin secretion | |
| calcium ion transmembrane transport | |
| cellular calcium ion homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| calcium ion transport into cytosol | |
| regulation of organ growth | |
| ion transport | |
| calcium ion transport | |
| regulation of blood pressure | |
| glucose homeostasis | |
| protein domain specific binding | |
| calmodulin binding | |
| protein phosphatase 2A binding | |
| calcium ion binding | |
| ion channel activity | |
| voltage-gated ion channel activity | |
| calcium channel activity | |
| voltage-gated calcium channel activity | |
| dihydropyridine-sensitive calcium channel activity | |
| presynaptic membrane | |
| postsynaptic density | |
| membrane | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| dendritic shaft | |
| Z disc | |
| nucleus | |
| membrane fraction | |
| caveolar macromolecular signaling complex | |
| T-tubule | |
| voltage-gated calcium channel complex | |
| integral to membrane | |
| dendrite | |
| sarcolemma |
| MedScan ID | 775 |
|---|
| Hugo ID | 1390 |
|---|
| Human chromosome position | 12p13.3 |
|---|
| LocusLink ID | 775 |
|---|---|
| 12288 | |
| 24239 |
| Alias | TS |
|---|---|
| CACH2 | |
| CACN2 | |
| CaV1.2 | |
| CCHL1A1 | |
| CACNL1A1 | |
| MGC120730 | |
| voltage-dependent L-type calcium channel subunit alpha-1C | |
| OTTHUMP00000196730 | |
| OTTHUMP00000196731 | |
| OTTHUMP00000196732 | |
| OTTHUMP00000196733 | |
| OTTHUMP00000196734 | |
| OTTHUMP00000196735 | |
| OTTHUMP00000196736 | |
| OTTHUMP00000196737 | |
| OTTHUMP00000196738 | |
| OTTHUMP00000196739 | |
| OTTHUMP00000196740 | |
| OTTHUMP00000196741 | |
| OTTHUMP00000196742 | |
| OTTHUMP00000196744 | |
| OTTHUMP00000196746 | |
| OTTHUMP00000196747 | |
| OTTHUMP00000196748 | |
| OTTHUMP00000196749 | |
| OTTHUMP00000196750 | |
| OTTHUMP00000196751 | |
| DHPR, alpha-1 subunit | |
| voltage-gated calcium channel alpha subunit Cav1.2 | |
| voltage-gated calcium channel subunit alpha Cav1.2 | |
| calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit | |
| calcium channel, L type, alpha 1 polypeptide, isoform 1, cardic muscle | |
| calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | |
| voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10* | |
| MBC | |
| MELC-CC | |
| L-type Cav1.2 | |
| brain class C | |
| skeletal muscle-specific calcium channel | |
| calcium channel voltage-dependent alpha1c subunit | |
| neuronal voltage-gated calcium channel alpha 1C subunit | |
| RATIVS302 | |
| RBC | |
| L-type calcium channel alpha-1 subunit | |
| calcium channel, voltage-dependent, alpha 1C subunit | |
| CaV1.2-a | |
| (alpha)1 subunit C | |
| AK092125 | |
| Ca channel, voltage-dependent, L type, alpha 1c subunit | |
| Cacna1c | |
| CACNL1A I | |
| calcium channel, voltage-dependent, L type, alpha 1C subunit | |
| CCHL1A I | |
| LOC283439 | |
| Voltage-dependent L-type calcium channel alpha-1C subunit |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 114205 |
|---|---|
| 611875 | |
| 601005 |
| Mouse chromosome position | 6 56.0 cM |
|---|
| GO ID | 0005516 |
|---|---|
| 0015270 | |
| 0019904 | |
| 0051721 | |
| 0005245 | |
| 0005244 | |
| 0006816 | |
| 0060402 | |
| 0007204 | |
| 0006811 | |
| 0055085 | |
| 0030315 | |
| 0030018 | |
| 0005737 | |
| 0030425 | |
| 0016021 | |
| 0005624 | |
| 0005886 | |
| 0014069 | |
| 0005891 | |
| 0005262 | |
| 0005216 | |
| 0007628 | |
| 0017156 | |
| 0006874 | |
| 0042593 | |
| 0030252 | |
| 0030073 | |
| 0008217 | |
| 0046620 | |
| 0019229 | |
| 0006939 | |
| 0060083 | |
| 0007268 | |
| 0006810 | |
| 0008542 | |
| 0002095 | |
| 0043198 | |
| 0016020 | |
| 0043025 | |
| 0005634 | |
| 0042734 | |
| 0042383 | |
| 0070588 | |
| 0051925 | |
| 0005509 |
| Rat chromosome position | 4q42 |
|---|
| PIR ID | A23660 |
|---|---|
| A44363 | |
| A45290 | |
| B23660 | |
| C23660 | |
| I54168 | |
| A44467 |
| Unigene ID | Hs.118262 |
|---|---|
| Mm.436656 | |
| Rn.9827 |
| KEGG ID | hsa:775 |
|---|---|
| mmu:12288 | |
| rno:24239 |
| Swiss-Prot ID | CAC1C_HUMAN |
|---|---|
| CAC1C_RAT | |
| CAC1C_MOUSE | |
| Q0PCR6_MOUSE | |
| B7ZN95_MOUSE | |
| A0SLC4_RAT | |
| Q3UY08_MOUSE | |
| Q5S8D1_MOUSE | |
| Q71QJ6_RAT |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Plasma membrane |
| IPI ID | IPI00016709 |
|---|---|
| IPI00216095 | |
| IPI00607583 | |
| IPI00744784 | |
| IPI00789111 | |
| IPI00789708 | |
| IPI00793099 | |
| IPI00793792 | |
| IPI00794300 | |
| IPI00794357 | |
| IPI00794799 | |
| IPI00797606 | |
| IPI00798235 | |
| IPI00827513 | |
| IPI00827543 | |
| IPI00827553 | |
| IPI00827578 | |
| IPI00827633 | |
| IPI00827681 | |
| IPI00827766 | |
| IPI00827775 | |
| IPI00827851 | |
| IPI00827855 | |
| IPI00827887 | |
| IPI00827942 | |
| IPI00827956 | |
| IPI00827998 | |
| IPI00828000 | |
| IPI00828035 | |
| IPI00828116 | |
| IPI00828128 | |
| IPI00828174 | |
| IPI00828206 | |
| IPI00828210 | |
| IPI00900275 | |
| IPI00231323 | |
| IPI00392650 | |
| IPI00476992 | |
| IPI00948183 | |
| IPI00949968 | |
| IPI00229513 | |
| IPI00277044 | |
| IPI00875159 | |
| IPI00128362 | |
| IPI00652543 | |
| IPI00479852 | |
| IPI00384621 | |
| IPI00793781 | |
| IPI00829604 | |
| IPI00792275 | |
| IPI00396912 | |
| IPI00852959 | |
| IPI00853140 | |
| IPI00788391 | |
| IPI00558680 | |
| IPI00551614 | |
| IPI00476009 | |
| IPI00231320 |
| Homologene ID | 55484 |
|---|
| RGD ID | 2245 |
|---|
| MGI ID | 103013 |
|---|