Ariadne Genomics Inc. Calm3 Calm1 Calm2 calmodulin Ca2+ ---- Calm3 Ca2+ Ca2+ ---- Calm1 Ca2+ ---- calmodulin Ca2+ ---- Calm2 Grin2b other Camk2 partners Camk2 phosphatases Cacng2 Gria1 Hdac5 Hdac4 Ryr2 Scn5a Cacna1c Cacng2 ---> Gria1 Camk2a ---> long-term synaptic potentiation Camk2b ---- other Camk2 partners Camk2a ---- other Camk2 partners Camk2a ---> Cacng2 Camk2a ---> Gria1 Camk2b ---> long-term synaptic potentiation long-term synaptic potentiation Camk2n1 ---| Camk2a Camk2n2 ---| Camk2a Camk2a Camk2n2 Camk2n1 Camk2a ---- Grin2b Camk2b ---- Grin2b Camk2b Camk2d ---> Ryr2 Camk2 phosphatases ---| Camk2a Camk2 phosphatases ---| Camk2g Camk2 phosphatases ---| Camk2b Camk2g Camk2 phosphatases ---| Camk2d calmodulin --+> Camk2b calmodulin --+> Camk2g calmodulin ---- Camk2g calmodulin --+> Camk2a calmodulin ---- Camk2a calmodulin --+> Camk2d calmodulin ---- Camk2d ROS ROS --+> Camk2d calmodulin ---- Camk2b Camk2d ---> Cacna1c Camk2d ---> excitation-contraction coupling Camk2d ---> Scn5a Camk2d ---> excitation-transcription coupling excitation-contraction coupling excitation-transcription coupling Camk2d ---> Hdac4 Camk2d Camk2d ---> Hdac5 Cacnb2 Camk2d ---> Cacnb2