| URN | urn:agi-llid:409 |
|---|---|
| Connectivity | 316 |
| Name | Arrb2 |
| Description | arrestin, beta 2 |
| Notes | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq] |
| Pathway | epinephrine signaling pathway via adrenergic receptor beta |
|---|---|
| angiotensin II signaling pathway via AT1 receptor | |
| corticotropin-releasing hormone signaling pathway | |
| calcium signaling pathway via the calcium-sensing receptor | |
| parathyroid hormone signaling pathway |
| GO Molecular Function | protein domain specific binding |
|---|---|
| clathrin binding | |
| receptor binding | |
| ubiquitin protein ligase binding | |
| G-protein-coupled receptor binding | |
| angiotensin receptor binding | |
| protein kinase B binding |
| GO Cellular Component | postsynaptic membrane |
|---|---|
| membrane | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| coated pit | |
| cytoplasmic vesicle | |
| cytoplasmic membrane-bounded vesicle | |
| nucleus |
| GO Biological Process | transport |
|---|---|
| negative regulation of interleukin-12 production | |
| negative regulation of tumor necrosis factor production | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-1 beta production | |
| positive regulation of synaptic transmission, dopaminergic | |
| sensory perception | |
| adult walking behavior | |
| endocytosis | |
| signal transduction | |
| negative regulation of signal transduction | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| negative regulation of toll-like receptor signaling pathway | |
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| regulation of cAMP catabolic process | |
| negative regulation of protein ubiquitination | |
| regulation of protein amino acid phosphorylation | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of cAMP biosynthetic process | |
| negative regulation of natural killer cell mediated cytotoxicity | |
| receptor internalization | |
| G-protein coupled receptor internalization | |
| cell chemotaxis | |
| transcription from RNA polymerase II promoter | |
| protein ubiquitination | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| protein transport | |
| G-protein coupled receptor protein signaling pathway | |
| transforming growth factor beta receptor signaling pathway |
| Group | transport |
|---|---|
| negative regulation of interleukin-12 production | |
| negative regulation of tumor necrosis factor production | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-1 beta production | |
| positive regulation of synaptic transmission, dopaminergic | |
| sensory perception | |
| adult walking behavior | |
| endocytosis | |
| signal transduction | |
| negative regulation of signal transduction | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| negative regulation of toll-like receptor signaling pathway | |
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| regulation of cAMP catabolic process | |
| negative regulation of protein ubiquitination | |
| regulation of protein amino acid phosphorylation | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of cAMP biosynthetic process | |
| negative regulation of natural killer cell mediated cytotoxicity | |
| receptor internalization | |
| G-protein coupled receptor internalization | |
| cell chemotaxis | |
| transcription from RNA polymerase II promoter | |
| protein ubiquitination | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| protein transport | |
| G-protein coupled receptor protein signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| protein domain specific binding | |
| clathrin binding | |
| receptor binding | |
| ubiquitin protein ligase binding | |
| G-protein-coupled receptor binding | |
| angiotensin receptor binding | |
| protein kinase B binding | |
| postsynaptic membrane | |
| membrane | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| coated pit | |
| cytoplasmic vesicle | |
| cytoplasmic membrane-bounded vesicle | |
| nucleus |
| MedScan ID | 409 |
|---|
| Hugo ID | 712 |
|---|
| Human chromosome position | 17p13 |
|---|
| LocusLink ID | 409 |
|---|---|
| 216869 | |
| 25388 |
| Alias | ARB2 |
|---|---|
| ARR2 | |
| BARR2 | |
| DKFZp686L0365 | |
| beta-arrestin-2 | |
| arrestin 3 | |
| arrestin beta-2 | |
| AI326910 | |
| AW122872 | |
| RP23-42P20.7 | |
| DN-491F10.4 | |
| beta arr2 | |
| beta-arrestin2 | |
| OTTMUSP00000006315 | |
| OTTMUSP00000006316 | |
| OTTMUSP00000006318 | |
| BARRES | |
| MGC105502 | |
| ARRB2 | |
| arrestin 2 | |
| arrestin beta 2 | |
| arrestin beta II | |
| arrestin II | |
| Beta-arrestin II | |
| LOC216869 | |
| arrestin, beta 2 | |
| Beta-arrestin 2 | |
| Beta-arrestin 2 (Arrestin, beta 2) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 107941 |
|---|
| Mouse chromosome position | 11 45.0 cM |
|---|
| GO ID | 0001664 |
|---|---|
| 0031701 | |
| 0005102 | |
| 0031625 | |
| 0002031 | |
| 0060326 | |
| 0002032 | |
| 0032088 | |
| 0045953 | |
| 0031397 | |
| 0009968 | |
| 0070374 | |
| 0043161 | |
| 0015031 | |
| 0016567 | |
| 0031623 | |
| 0007600 | |
| 0006366 | |
| 0007179 | |
| 0005905 | |
| 0005737 | |
| 0016023 | |
| 0031410 | |
| 0005634 | |
| 0005886 | |
| 0019904 | |
| 0043422 | |
| 0007186 | |
| 0007628 | |
| 0006897 | |
| 0032691 | |
| 0032695 | |
| 0032715 | |
| 0034122 | |
| 0032720 | |
| 0051897 | |
| 0032226 | |
| 0008277 | |
| 0001932 | |
| 0007165 | |
| 0006810 | |
| 0005622 | |
| 0016020 | |
| 0045211 | |
| 0030276 | |
| 0030817 | |
| 0030820 | |
| 0005515 | |
| 0050896 |
| Rat chromosome position | 10q24 |
|---|
| Swiss-Prot Accession | P32121 |
|---|---|
| Q59EM5 | |
| Q68DZ5 | |
| Q91YI4 | |
| Q3TRC8 | |
| Q3UCU5 | |
| Q5F2D9 | |
| P29067 | |
| Q3TCM2 | |
| Q5F2D8 | |
| Q5F2E0 | |
| B5B0C0 | |
| B7WPL3 | |
| Q0Z8D3 | |
| Q2PP19 | |
| Q6ICT3 | |
| Q8N7Y2 | |
| Q9UEQ6 | |
| D3DTK2 |
| PIR ID | A59279 |
|---|---|
| S18984 |
| Unigene ID | Hs.435811 |
|---|---|
| Mm.203747 | |
| Rn.32973 |
| KEGG ID | hsa:409 |
|---|---|
| mmu:216869 | |
| rno:25388 |
| Swiss-Prot ID | ARRB2_RAT |
|---|---|
| ARRB2_MOUSE | |
| ARRB2_HUMAN | |
| D3DTK2_HUMAN | |
| B5B0C0_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane | |
| Membrane | |
| clathrin-coated pit | |
| Cytoplasmic vesicle |
| IPI ID | IPI00231135 |
|---|---|
| IPI00130214 | |
| IPI00647964 | |
| IPI00180375 | |
| IPI00783893 | |
| IPI00786904 | |
| IPI00395607 | |
| IPI00795723 | |
| IPI00793794 | |
| IPI00648751 | |
| IPI00777302 |
| Homologene ID | 3183 |
|---|
| RGD ID | 2157 |
|---|
| MGI ID | 99474 |
|---|