| URN | urn:agi-llid:387 |
|---|---|
| Connectivity | 1431 |
| Name | Rhoa |
| Description | ras homolog gene family, member A |
| Notes | results provide first evidence that RhoA in vivo acts downstream of Wnt5 and Wnt11 to effect, without affecting cell fates, the convergence and extension movements in zebrafish embryos; it elicits such effect via both effectors, Rho kinase and Dia Results provide first evidence that RhoA in vivo acts downstream of Wnt5 and Wnt11 to effect, without affecting cell fates, the convergence and extension movements in zebrafish embryos; it elicits such effect via both effectors, Rho kinase and Dia. |
| Pathway | EphrinR -> actin signaling |
|---|---|
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| SerotoninR1 -> FOS signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| FrizzledR -> JUN/PAX2 signaling | |
| the planar cell polarity Wnt signaling pathway | |
| the planar cell polarity Wnt signaling pathway | |
| calcium signaling pathway via the calcium-sensing receptor |
| GO Molecular Function | nucleotide binding |
|---|---|
| protein domain specific binding | |
| myosin binding | |
| GTP binding | |
| magnesium ion binding | |
| GTPase activity |
| GO Cellular Component | membrane |
|---|---|
| intracellular | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| cytoskeleton | |
| nucleus | |
| membrane fraction | |
| axon |
| GO Biological Process | cell adhesion |
|---|---|
| interspecies interaction between organisms | |
| cell differentiation | |
| regulation of dendrite development | |
| negative regulation of axonogenesis | |
| negative regulation of neuron differentiation | |
| positive regulation of neuron differentiation | |
| positive regulation of axonogenesis | |
| regulation of axonogenesis | |
| skeletal muscle tissue development | |
| cell morphogenesis | |
| neuron projection morphogenesis | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| positive regulation of cell adhesion | |
| positive regulation of cell growth | |
| actin cytoskeleton organization | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of steroid hormone receptor signaling pathway | |
| small GTPase mediated signal transduction | |
| stress-activated protein kinase signaling pathway | |
| Rho protein signal transduction | |
| positive regulation of translation | |
| regulation of transcription from RNA polymerase II promoter | |
| positive regulation of actin filament polymerization | |
| positive regulation of cell migration | |
| positive regulation of stress fiber assembly | |
| positive regulation of neuron apoptosis | |
| negative regulation of neuron apoptosis | |
| positive regulation of NF-kappaB import into nucleus | |
| regulation of actin polymerization or depolymerization | |
| positive regulation of caspase activity | |
| negative regulation of calcium ion transport via voltage-gated calcium channel activity | |
| cell-matrix adhesion | |
| stress fiber assembly | |
| response to mechanical stimulus | |
| response to drug | |
| response to hypoxia | |
| response to amino acid stimulus | |
| response to ethanol | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| integrin-mediated signaling pathway | |
| androgen receptor signaling pathway |
| Ariadne Ontology | Rho |
|---|---|
| Oncogenes |
| Group | Rho |
|---|---|
| Oncogenes | |
| cell adhesion | |
| interspecies interaction between organisms | |
| cell differentiation | |
| regulation of dendrite development | |
| negative regulation of axonogenesis | |
| negative regulation of neuron differentiation | |
| positive regulation of neuron differentiation | |
| positive regulation of axonogenesis | |
| regulation of axonogenesis | |
| skeletal muscle tissue development | |
| cell morphogenesis | |
| neuron projection morphogenesis | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| positive regulation of cell adhesion | |
| positive regulation of cell growth | |
| actin cytoskeleton organization | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of steroid hormone receptor signaling pathway | |
| small GTPase mediated signal transduction | |
| stress-activated protein kinase signaling pathway | |
| Rho protein signal transduction | |
| positive regulation of translation | |
| regulation of transcription from RNA polymerase II promoter | |
| positive regulation of actin filament polymerization | |
| positive regulation of cell migration | |
| positive regulation of stress fiber assembly | |
| positive regulation of neuron apoptosis | |
| negative regulation of neuron apoptosis | |
| positive regulation of NF-kappaB import into nucleus | |
| regulation of actin polymerization or depolymerization | |
| positive regulation of caspase activity | |
| negative regulation of calcium ion transport via voltage-gated calcium channel activity | |
| cell-matrix adhesion | |
| stress fiber assembly | |
| response to mechanical stimulus | |
| response to drug | |
| response to hypoxia | |
| response to amino acid stimulus | |
| response to ethanol | |
| response to glucocorticoid stimulus | |
| response to glucose stimulus | |
| integrin-mediated signaling pathway | |
| androgen receptor signaling pathway | |
| nucleotide binding | |
| protein domain specific binding | |
| myosin binding | |
| GTP binding | |
| magnesium ion binding | |
| GTPase activity | |
| membrane | |
| intracellular | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| cytoskeleton | |
| nucleus | |
| membrane fraction | |
| axon |
| MedScan ID | 387 |
|---|
| Hugo ID | 667 |
|---|
| Human chromosome position | 3p21.3 |
|---|
| LocusLink ID | 387 |
|---|---|
| 11848 | |
| 117273 | |
| 50886 | |
| 51787 | |
| 107443 | |
| 297173 | |
| 338049 | |
| 336001 |
| Alias | ARHA |
|---|---|
| ARH12 | |
| RHO12 | |
| RHOH12 | |
| transforming protein RhoA | |
| h12 | |
| oncogene RHO H12 | |
| rho cDNA clone 12 | |
| OTTHUMP00000210783 | |
| OTTHUMP00000210785 | |
| Aplysia ras-related homolog 12 | |
| small GTP binding protein RhoA | |
| Arha1 | |
| Arha2 | |
| ras homolog A1 | |
| ras homolog A2 | |
| Rho family GTPase | |
| aplysia ras-related homolog A | |
| aplysia ras-related homolog A1 | |
| aplysia ras-related homolog A2 | |
| ras homolog gene family, member A1 | |
| ras homolog gene family, member A2 | |
| MGC72339 | |
| plysia ras-related homolog A2 | |
| Arha I | |
| MGC94489 | |
| RAS homolog gene family, member A | |
| Rho A | |
| Rho family GTPase A | |
| RHO H12 | |
| RhoA | |
| Rho-A | |
| RhoA activity | |
| RhoA small GTPase | |
| RSA-14-44 | |
| RHOH12s | |
| 4930544G11Rik | |
| Transforming protein RhoA (H12) | |
| RIKEN cDNA 4930544G11 gene | |
| Ras homolog gene family, member A (oncogene RHO H12) | |
| Aplysia ras-related homolog XII | |
| MGC114074 | |
| chromosome | |
| fj42e08 | |
| ras homolog gene family, member Ab | |
| rhoab | |
| scaffold | |
| small GTPase RhoA | |
| wu:fj42e08 | |
| zgc:92206 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 165390 |
|---|
| Mouse chromosome position | 9 |
|---|---|
| 9 F2 |
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0017022 | |
| 0000166 | |
| 0007266 | |
| 0030036 | |
| 0030521 | |
| 0007155 | |
| 0030154 | |
| 0000902 | |
| 0007160 | |
| 0044419 | |
| 0050771 | |
| 0043524 | |
| 0033144 | |
| 0043123 | |
| 0042346 | |
| 0050772 | |
| 0045666 | |
| 0051496 | |
| 0050770 | |
| 0006357 | |
| 0007519 | |
| 0007264 | |
| 0005737 | |
| 0005856 | |
| 0005622 | |
| 0005739 | |
| 0005634 | |
| 0005886 | |
| 0019904 | |
| 0007229 | |
| 0043124 | |
| 0051927 | |
| 0045665 | |
| 0030838 | |
| 0043280 | |
| 0030307 | |
| 0043525 | |
| 0050773 | |
| 0042493 | |
| 0043149 | |
| 0031098 | |
| 0030424 | |
| 0005829 | |
| 0016020 | |
| 0005624 | |
| 0005625 | |
| 0048812 | |
| 0045785 | |
| 0030335 | |
| 0045987 | |
| 0045727 | |
| 0045907 | |
| 0008064 | |
| 0043200 | |
| 0045471 | |
| 0051384 | |
| 0009749 | |
| 0001666 | |
| 0009612 | |
| 0000287 | |
| 0005515 | |
| 0004871 | |
| 0015031 | |
| 0005579 | |
| 0016055 | |
| 0035121 | |
| 0042074 | |
| 0048840 |
| Rat chromosome position | 16q12.5 |
|---|
| Swiss-Prot Accession | P61586 |
|---|---|
| Q9BVT0 | |
| Q4VAE6 | |
| Q9QUI0 | |
| Q3TN61 | |
| P61589 | |
| O35791 | |
| P06749 | |
| Q53HM4 | |
| Q5U024 | |
| Q9UDJ0 | |
| Q9UEJ4 | |
| O88336 | |
| RHOA_HUMAN |
| PIR ID | A26675 |
|---|
| Unigene ID | Hs.247077 |
|---|---|
| Mm.757 | |
| Mm.471622 | |
| Rn.107401 | |
| Hs.709788 | |
| Rn.47032 | |
| Bt.49678 | |
| Dr.25812 | |
| Hs.657976 |
| KEGG ID | hsa:387 |
|---|---|
| mmu:11848 | |
| rno:117273 |
| Swiss-Prot ID | RHOA_HUMAN |
|---|---|
| RHOA_MOUSE | |
| RHOA_RAT | |
| Q4VAE6_MOUSE | |
| Q9BVT0_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm | |
| cytoskeleton |
| IPI ID | IPI00478231 |
|---|---|
| IPI00315100 | |
| IPI00201699 | |
| IPI00789934 |
| Homologene ID | 1257 |
|---|
| RGD ID | 619921 |
|---|
| MGI ID | 1096342 |
|---|---|
| 1355308 |
| Microarray ID | 101111_at |
|---|---|
| 101112_g_at | |
| 101113_at | |
| 200059_s_at | |
| 1437628_s_at |
| FunctionalClass | GTP binding |
|---|---|
| GTPase | |
| magnesium ion binding | |
| nucleotide binding | |
| protein binding | |
| signal transducer |
| Mus musculus Chromosome position | 9 F2 |
|---|---|
| 9 | |
| 2 |
| Source | Curated |
|---|---|
| GO component |
| KEGG pathway | Adherens junction |
|---|---|
| Axon guidance | |
| Focal adhesion | |
| Leukocyte transendothelial migration | |
| Regulation of actin cytoskeleton | |
| T cell receptor signaling pathway | |
| TGF-beta signaling pathway | |
| Tight junction | |
| Wnt signaling pathway |
| Homo sapiens Chromosome position | 3p21.3 |
|---|
| Bos taurus Chromosome position | 22 |
|---|
| Rattus norvegicus Chromosome position | 16q12.5 |
|---|---|
| 4q31 |