Ariadne Genomics Inc. Arrb2 Arrb1 G protein mediated signaling pathway via Galphai family --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway DAG IP3 Flna Rhoa increased DAG/IP3 via PLC activation Arrb2 ---- Casr Arrb1 ---- Casr Casr ---| parathyroid hormone signaling pathway Casr ---| PTH secretion Ca absoprtion, water balance calcimimetics ---- Casr calcilytics ---- Casr calcimimetics --+> Casr calcilytics ---| Casr Ca2+ ---- Casr G protein mediated signaling pathway via Galphaq family ---> increased DAG/IP3 via PLC activation Casr ---- Casr binding partners Casr ---> Ca absoprtion, water balance Casr --+> G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphaq family --+> Rho/Rac/Cdc42 mediated signaling pathway G protein mediated signaling pathway via Galpha12/Galpha13 family --+> Rho/Rac/Cdc42 mediated signaling pathway inhibition of adenylyl cyclases/decreased cAMP G protein mediated signaling pathway via Galphai family ---> inhibition of adenylyl cyclases/decreased cAMP RGS proteins ---| G protein mediated signaling pathway via Galphai family Arrb1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Arrb2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Casr RGS proteins ---| G protein mediated signaling pathway via Galphaq family RGS proteins ---| G protein mediated signaling pathway via Galpha12/Galpha13 family Casr ---- Flna G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galpha12/Galpha13 family Rho/Rac/Cdc42 mediated signaling pathway protein kinase C (PKC) signaling pathway parathyroid hormone signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway Casr binding partners GRKs RGS proteins receptor desensitization PTH secretion calcimimetics calcilytics Ca2+ Casr --+> G protein mediated signaling pathway via Galphai family Casr --+> G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway via Galphaq family --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway increased DAG/IP3 via PLC activation --+> protein kinase C (PKC) signaling pathway GRKs ---| Casr