| URN | urn:agi-llid:57620 |
|---|---|
| Connectivity | 20 |
| Name | Stim2 |
| Description | stromal interaction molecule 2 |
| Notes | This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq] |
| Pathway | calcium transport pathway |
|---|---|
| calcium/calcium-mediated signaling pathway | |
| calcium-calcium-mediated signaling pathway | |
| calcium-calcium-mediated signaling pathway |
| GO Molecular Function | calcium channel regulator activity |
|---|---|
| calcium ion binding |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| GO Biological Process | transport |
|---|---|
| negative regulation of calcium ion transport via store-operated calcium channel activity | |
| activation of store-operated calcium channel activity | |
| cellular calcium ion homeostasis | |
| positive regulation of calcium ion transport | |
| ion transport | |
| calcium ion transport |
| Group | transport |
|---|---|
| negative regulation of calcium ion transport via store-operated calcium channel activity | |
| activation of store-operated calcium channel activity | |
| cellular calcium ion homeostasis | |
| positive regulation of calcium ion transport | |
| ion transport | |
| calcium ion transport | |
| calcium channel regulator activity | |
| calcium ion binding | |
| membrane | |
| plasma membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| MedScan ID | 57620 |
|---|
| Hugo ID | 19205 |
|---|
| Human chromosome position | 4p15.2 |
|---|
| LocusLink ID | 57620 |
|---|---|
| 116873 | |
| 117087 |
| Alias | FLJ39527 |
|---|---|
| KIAA1482 | |
| stromal interaction molecule 2 | |
| OTTHUMP00000123457 | |
| OTTHUMP00000123458 | |
| OTTHUMP00000216198 | |
| OTTMUSP00000032575 | |
| LOC305379 | |
| STIM2 | |
| stromal interacting molecule 2 | |
| stromal interacting molecule II | |
| stromal interaction molecule II | |
| stromal interactive molecule 2 | |
| stromal interactive molecule II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 610841 |
|---|
| Mouse chromosome position | 5 34.0 cM |
|---|
| GO ID | 0005246 |
|---|---|
| 0005509 | |
| 0032237 | |
| 0006874 | |
| 0006811 | |
| 0032235 | |
| 0051928 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0005886 | |
| 0006816 | |
| 0006810 | |
| 0016020 |
| Rat chromosome position | 14q11 |
|---|
| Swiss-Prot Accession | Q9P246 |
|---|---|
| Q05BJ5 | |
| A5CVE4 | |
| P83093 | |
| Q8BIM2 | |
| Q8C4Z8 | |
| Q96BF1 | |
| Q9BQH2 | |
| Q9H8R1 | |
| Q69ZI3 | |
| Q80VF4 | |
| A6H8L7 | |
| B3KUB5 |
| Unigene ID | Hs.724550 |
|---|---|
| Mm.265985 | |
| Rn.162277 |
| KEGG ID | hsa:57620 |
|---|---|
| mmu:116873 | |
| rno:117087 |
| Swiss-Prot ID | STIM2_HUMAN |
|---|---|
| STIM2_MOUSE | |
| A6H8L7_HUMAN | |
| B3KUB5_HUMAN | |
| A5CVE4_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|
| IPI ID | IPI00942329 |
|---|---|
| IPI00830628 | |
| IPI00658128 | |
| IPI00001727 | |
| IPI00874542 | |
| IPI00464163 | |
| IPI00780770 | |
| IPI00776567 | |
| IPI00364551 |
| Homologene ID | 32490 |
|---|
| RGD ID | 1304641 |
|---|
| MGI ID | 2151156 |
|---|