| URN | urn:agi-llid:6786 |
|---|---|
| Connectivity | 104 |
| Name | Stim1 |
| Description | stromal interaction molecule 1 |
| Notes | This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. |
| Pathway | calcium transport pathway |
|---|---|
| calcium/calcium-mediated signaling pathway | |
| calcium-calcium-mediated signaling pathway | |
| calcium-calcium-mediated signaling pathway |
| GO Molecular Function | microtubule plus-end binding |
|---|---|
| calcium ion binding |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to endoplasmic reticulum membrane | |
| microtubule | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | transport |
|---|---|
| activation of store-operated calcium channel activity | |
| detection of calcium ion | |
| regulation of calcium ion transport | |
| ion transport | |
| cation transport | |
| calcium ion transport |
| Group | transport |
|---|---|
| activation of store-operated calcium channel activity | |
| detection of calcium ion | |
| regulation of calcium ion transport | |
| ion transport | |
| cation transport | |
| calcium ion transport | |
| microtubule plus-end binding | |
| calcium ion binding | |
| membrane | |
| plasma membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to endoplasmic reticulum membrane | |
| microtubule | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 6786 |
|---|
| Hugo ID | 11386 |
|---|
| Human chromosome position | 11p15.5 |
|---|
| LocusLink ID | 6786 |
|---|---|
| 20866 | |
| 361618 |
| Alias | GOK |
|---|---|
| D11S4896E | |
| stromal interaction molecule 1 | |
| SIM | |
| LOC293159 | |
| STIM I | |
| STIM1 | |
| stromal interacting molecule 1 | |
| stromal interacting molecule I | |
| stromal interaction molecule I | |
| stromal interactive molecule 1 | |
| stromal interactive molecule I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605921 |
|---|---|
| 612783 |
| Mouse chromosome position | 7 50.0 cM |
|---|
| GO ID | 0005509 |
|---|---|
| 0051010 | |
| 0032237 | |
| 0006812 | |
| 0005513 | |
| 0051924 | |
| 0005783 | |
| 0005789 | |
| 0030176 | |
| 0005887 | |
| 0005874 | |
| 0005886 | |
| 0006816 | |
| 0006811 | |
| 0006810 | |
| 0016021 | |
| 0016020 |
| Rat chromosome position | 1q32 |
|---|
| Swiss-Prot Accession | Q13586 |
|---|---|
| Q8K1E1 | |
| P70302 | |
| Q3TUX9 | |
| P84903 | |
| Q8N382 |
| Unigene ID | Hs.501735 |
|---|---|
| Mm.645 | |
| Rn.106771 |
| KEGG ID | hsa:6786 |
|---|---|
| mmu:20866 | |
| rno:361618 |
| Swiss-Prot ID | STIM1_RAT |
|---|---|
| STIM1_HUMAN | |
| Q8K1E1_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Endoplasmic reticulum membrane |
| IPI ID | IPI00365792 |
|---|---|
| IPI00299063 | |
| IPI00108041 | |
| IPI00331631 |
| Homologene ID | 20681 |
|---|
| RGD ID | 1306831 |
|---|
| MGI ID | 107476 |
|---|