| URN | urn:agi-llid:846 |
|---|---|
| Connectivity | 336 |
| Name | Casr |
| Description | calcium-sensing receptor |
| Notes | The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq] |
| Pathway | calcium/calcium-mediated signaling pathway |
|---|---|
| calcium-calcium-mediated signaling pathway | |
| calcium-calcium-mediated signaling pathway | |
| calcium signaling pathway via the calcium-sensing receptor |
| GO Molecular Function | signal transducer activity |
|---|---|
| phosphoinositide phospholipase C activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| axon terminus |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| anatomical structure morphogenesis | |
| ossification | |
| vasodilation | |
| signal transduction | |
| calcium-mediated signaling | |
| JNK cascade | |
| positive regulation of ATPase activity | |
| cellular calcium ion homeostasis | |
| chemosensory behavior | |
| detection of calcium ion | |
| regulation of calcium ion transport | |
| calcium ion transport | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | GPCR-Gq-iCR |
|---|
| Group | GPCR-Gq-iCR |
|---|---|
| positive regulation of cell proliferation | |
| anatomical structure morphogenesis | |
| ossification | |
| vasodilation | |
| signal transduction | |
| calcium-mediated signaling | |
| JNK cascade | |
| positive regulation of ATPase activity | |
| cellular calcium ion homeostasis | |
| chemosensory behavior | |
| detection of calcium ion | |
| regulation of calcium ion transport | |
| calcium ion transport | |
| G-protein coupled receptor protein signaling pathway | |
| signal transducer activity | |
| phosphoinositide phospholipase C activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| axon terminus |
| MedScan ID | 846 |
|---|
| Hugo ID | 1514 |
|---|
| Human chromosome position | 3q13 |
|---|
| LocusLink ID | 846 |
|---|---|
| 12374 | |
| 24247 |
| Alias | CAR |
|---|---|
| FHH | |
| FIH | |
| HHC | |
| EIG8 | |
| HHC1 | |
| NSHPT | |
| PCAR1 | |
| GPRC2A | |
| MGC138441 | |
| extracellular calcium-sensing receptor | |
| OTTHUMP00000215576 | |
| OTTHUMP00000215577 | |
| parathyroid Ca(2+)-sensing receptor 1 | |
| parathyroid cell calcium-sensing receptor | |
| cation sensing receptor | |
| G protein coupled receptor, family C, group 2, member A | |
| G protein-coupled receptor, family C, group 2, member A | |
| Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism) | |
| Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) | |
| 1700108E19Rik | |
| 4930562N12 | |
| 4930562N12Rik | |
| AK039689 | |
| calcium sensing receptor, related sequence 4 | |
| calcium sensing receptor, related sequence 5 | |
| calcium sensing receptor, related sequence IV | |
| calcium sensing receptor, related sequence V | |
| Calcium-sensing receptor | |
| calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hy | |
| calcium-sensing receptor related protein 3 | |
| calcium-sensing receptor related protein III | |
| Calcium-sensing receptors | |
| CASR | |
| CASR_HUMAN | |
| Casr-rs4 | |
| Casr-rs5 | |
| cation sensing receptors | |
| Extracellular calcium-sensing receptor precursors | |
| G protein-coupled [Ca(2)](o)-sensing receptor | |
| G protein-coupled [Ca(2+)](o)-sensing receptor | |
| Gprc2a-rs4 | |
| Gprc2a-rs5 | |
| HHC I | |
| LOC286914 | |
| LOC286981 | |
| LOC286982 | |
| LOC286983 | |
| LOC286984 | |
| LOC286985 | |
| LOC286986 | |
| LOC56544 | |
| LOC56552 | |
| parathyroid Ca(2)-sensing receptor 1 | |
| parathyroid Ca(2)-sensing receptor I | |
| parathyroid Ca(2+)-sensing receptor I | |
| parathyroid calcium-sensing receptor 1 | |
| parathyroid calcium-sensing receptor I | |
| Parathyroid Cell calcium-sensing receptors | |
| PCAR I | |
| severe neonatal hyperparathyroidism gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601199 |
|---|---|
| 612899 | |
| 239200 | |
| 146200 | |
| 145980 |
| Mouse chromosome position | 16 26.3 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0004435 | |
| 0004872 | |
| 0007186 | |
| 0009653 | |
| 0019722 | |
| 0006874 | |
| 0007635 | |
| 0005513 | |
| 0001503 | |
| 0005887 | |
| 0005886 | |
| 0004871 | |
| 0007254 | |
| 0006816 | |
| 0032781 | |
| 0008284 | |
| 0051924 | |
| 0007165 | |
| 0042311 | |
| 0043679 | |
| 0016021 | |
| 0016020 |
| Rat chromosome position | 11q22 |
|---|
| Swiss-Prot Accession | P41180 |
|---|---|
| Q2F3K1 | |
| Q2F3K2 | |
| Q2F3K3 | |
| Q2F3K4 | |
| Q2F3K5 | |
| Q2F3K6 | |
| Q86UN7 | |
| Q8CDP3 | |
| Q9QY96 | |
| O88982 | |
| P48442 | |
| Q80ZA8 | |
| O08968 | |
| O88519 | |
| Q9QY95 | |
| Q9QZU8 | |
| Q9R1D6 | |
| Q9R1Y2 | |
| Q13912 | |
| Q16108 | |
| Q16109 | |
| Q16110 | |
| Q16379 | |
| Q2M1T0 | |
| Q4PJ19 |
| PIR ID | I59362 |
|---|---|
| A56715 | |
| B56715 |
| Unigene ID | Hs.435615 |
|---|---|
| Mm.103619 | |
| Rn.10019 |
| KEGG ID | hsa:846 |
|---|---|
| mmu:12374 | |
| rno:24247 |
| Swiss-Prot ID | CASR_RAT |
|---|---|
| CASR_MOUSE | |
| CASR_HUMAN | |
| Q8CDP3_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00190846 |
|---|---|
| IPI00135702 | |
| IPI00230189 | |
| IPI00012817 | |
| IPI00216479 | |
| IPI00794666 | |
| IPI00569575 |
| Homologene ID | 332 |
|---|
| RGD ID | 2277 |
|---|
| MGI ID | 1351351 |
|---|