| URN | urn:agi-llid:7430 |
|---|---|
| Connectivity | 332 |
| Name | Ezr |
| Description | ezrin |
| Notes | The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq] |
| Pathway | parathyroid hormone signaling pathway |
|---|
| GO Molecular Function | structural molecule activity |
|---|---|
| cytoskeletal protein binding | |
| cell adhesion molecule binding | |
| actin filament binding |
| GO Cellular Component | apical part of cell |
|---|---|
| cell projection | |
| membrane | |
| plasma membrane | |
| uropod | |
| ruffle | |
| microvillus | |
| filopodium | |
| cytoplasm | |
| microtubule basal body | |
| extrinsic to membrane | |
| cell cortex | |
| cytosol | |
| cortical cytoskeleton | |
| actin filament | |
| cytoskeleton | |
| actin cytoskeleton | |
| apical plasma membrane | |
| ruffle membrane | |
| microvillus membrane |
| GO Biological Process | epithelial cell differentiation |
|---|---|
| regulation of cell shape | |
| establishment or maintenance of apical-basal cell polarity | |
| membrane to membrane docking | |
| leukocyte cell-cell adhesion | |
| cytoskeletal anchoring at plasma membrane | |
| actin filament bundle assembly |
| Ariadne Ontology | Actin-based cytoskeleton assembly |
|---|
| Group | Actin-based cytoskeleton assembly |
|---|---|
| structural molecule activity | |
| epithelial cell differentiation | |
| regulation of cell shape | |
| establishment or maintenance of apical-basal cell polarity | |
| membrane to membrane docking | |
| leukocyte cell-cell adhesion | |
| cytoskeletal anchoring at plasma membrane | |
| actin filament bundle assembly | |
| cytoskeletal protein binding | |
| cell adhesion molecule binding | |
| actin filament binding | |
| apical part of cell | |
| cell projection | |
| membrane | |
| plasma membrane | |
| uropod | |
| ruffle | |
| microvillus | |
| filopodium | |
| cytoplasm | |
| microtubule basal body | |
| extrinsic to membrane | |
| cell cortex | |
| cytosol | |
| cortical cytoskeleton | |
| actin filament | |
| cytoskeleton | |
| actin cytoskeleton | |
| apical plasma membrane | |
| ruffle membrane | |
| microvillus membrane |
| MedScan ID | 7430 |
|---|
| Hugo ID | 12691 |
|---|
| Human chromosome position | 6q25.2-q26 |
|---|
| LocusLink ID | 7430 |
|---|---|
| 22350 | |
| 54319 |
| Alias | CVL |
|---|---|
| CVIL | |
| VIL2 | |
| MGC1584 | |
| FLJ26216 | |
| DKFZp762H157 | |
| ezrin | |
| p81 | |
| villin-2 | |
| cytovillin 2 | |
| villin 2 (ezrin) | |
| R75297 | |
| AW146364 | |
| MGC107499 | |
| villin 2 | |
| cytovillin | |
| OTTMUSP00000019758 | |
| MGC94076 | |
| cytovillins | |
| Ezrin (p81) (Cytovillin) (Villin 2) | |
| ezrins | |
| OTTHUMP00000017506 | |
| OTTHUMP00000017507 | |
| Villin II | |
| Villin-2 (cytovillin) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 123900 |
|---|
| Mouse chromosome position | 17 |
|---|
| GO ID | 0051015 |
|---|---|
| 0050839 | |
| 0008092 | |
| 0051017 | |
| 0007016 | |
| 0030855 | |
| 0035088 | |
| 0007159 | |
| 0022614 | |
| 0008360 | |
| 0015629 | |
| 0005884 | |
| 0045177 | |
| 0016324 | |
| 0005938 | |
| 0030863 | |
| 0005737 | |
| 0005829 | |
| 0019898 | |
| 0030175 | |
| 0005932 | |
| 0005902 | |
| 0031528 | |
| 0005886 | |
| 0001726 | |
| 0032587 | |
| 0001931 | |
| 0042995 | |
| 0005856 | |
| 0016020 | |
| 0005198 |
| Rat chromosome position | 1q11 |
|---|
| Swiss-Prot Accession | P15311 |
|---|---|
| Q6NUR7 | |
| Q9UJU1 | |
| Q9UJZ2 | |
| Q9UJZ6 | |
| Q9UJZ7 | |
| Q9UJZ8 | |
| Q9UK20 | |
| P26040 | |
| Q3UL48 | |
| Q4KML7 | |
| Q8CBU4 | |
| Q3TCP5 | |
| Q3UXR4 | |
| P31977 | |
| P23714 | |
| Q4VX75 | |
| Q96CU8 | |
| Q9NSJ4 | |
| Q5WQV4 | |
| Q66H97 | |
| Q8VHK3 |
| PIR ID | A34400 |
|---|---|
| S58759 |
| Unigene ID | Hs.487027 |
|---|---|
| Mm.277812 | |
| Rn.773 |
| KEGG ID | hsa:7430 |
|---|---|
| mmu:22350 | |
| rno:54319 |
| Swiss-Prot ID | EZRI_HUMAN |
|---|---|
| EZRI_RAT | |
| Q8CBU4_MOUSE | |
| Q3UL48_MOUSE | |
| EZRI_MOUSE | |
| Q4KML7_MOUSE |
| Cell Localization | Apical cell membrane |
|---|---|
| Cell projection | |
| microvillus membrane | |
| ruffle membrane | |
| Cytoplasm | |
| cell cortex | |
| cytoskeleton |
| IPI ID | IPI00843975 |
|---|---|
| IPI00470254 | |
| IPI00761216 | |
| IPI00330862 | |
| IPI00384282 | |
| IPI00746388 | |
| IPI00872684 | |
| IPI00563268 |
| Homologene ID | 55740 |
|---|
| RGD ID | 621161 |
|---|
| MGI ID | 98931 |
|---|