| URN | urn:agi-llid:5745 |
|---|---|
| Connectivity | 268 |
| Name | Pth1r |
| Description | parathyroid hormone 1 receptor |
| Notes | The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] |
| Pathway | parathyroid hormone signaling pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| receptor activity | |
| transmembrane receptor activity | |
| G-protein coupled receptor activity | |
| parathyroid hormone receptor activity |
| GO Cellular Component | membrane |
|---|---|
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| nucleus | |
| basolateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| brush border membrane |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| ossification | |
| aging | |
| cell maturation | |
| skeletal system development | |
| bone mineralization | |
| osteoblast development | |
| chondrocyte differentiation | |
| signal transduction | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| cellular calcium ion homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| cell surface receptor linked signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| bone resorption |
| Ariadne Ontology | GPCR-Gq-sCR |
|---|
| Group | GPCR-Gq-sCR |
|---|---|
| negative regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| ossification | |
| aging | |
| cell maturation | |
| skeletal system development | |
| bone mineralization | |
| osteoblast development | |
| chondrocyte differentiation | |
| signal transduction | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| cellular calcium ion homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| cell surface receptor linked signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| bone resorption | |
| signal transducer activity | |
| receptor activity | |
| transmembrane receptor activity | |
| G-protein coupled receptor activity | |
| parathyroid hormone receptor activity | |
| membrane | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| nucleus | |
| basolateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| brush border membrane |
| MedScan ID | 5745 |
|---|
| Hugo ID | 9608 |
|---|
| Human chromosome position | 3p22-p21.1 |
|---|
| LocusLink ID | 5745 |
|---|---|
| 19228 | |
| 56813 |
| Alias | PFE |
|---|---|
| PTHR | |
| PTHR1 | |
| MGC138426 | |
| MGC138452 | |
| parathyroid hormone/parathyroid hormone-related peptide receptor | |
| PTH1 receptor | |
| PTH/PTHr receptor | |
| OTTHUMP00000209970 | |
| OTTHUMP00000209971 | |
| OTTHUMP00000209972 | |
| OTTHUMP00000209973 | |
| PTH/PTHrP type I receptor | |
| parathyroid hormone receptor 1 | |
| seven transmembrane helix receptor | |
| parathyroid hormone/parathyroid hormone-related protein receptor | |
| PPR | |
| PTH/PTHrP receptor | |
| PTH-related peptide receptor | |
| PTHrel | |
| LOC56813 | |
| parathyroid hormone 1 receptor | |
| parathyroid hormone receptor | |
| parathyroid hormone receptor I | |
| Parathyroid hormone/parathyroid hormone-related peptide receptors | |
| parathyroid hormone/parathyroid hormone-related protein receptors | |
| PTH receptor | |
| PTH/PTHR receptors | |
| PTH/PTHrP receptors | |
| PTH/PTHrP type I receptors | |
| PTH1R | |
| PTHR I | |
| PTH-related peptide receptors | |
| secreted protein SST3 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 168468 |
|---|---|
| 215045 | |
| 600002 | |
| 166000 | |
| 125350 | |
| 156400 |
| Mouse chromosome position | 9 58.0 cM |
|---|
| GO ID | 0004991 |
|---|---|
| 0007186 | |
| 0007187 | |
| 0001501 | |
| 0005737 | |
| 0005887 | |
| 0005634 | |
| 0005886 | |
| 0004930 | |
| 0004872 | |
| 0004871 | |
| 0004888 | |
| 0007189 | |
| 0007200 | |
| 0030282 | |
| 0045453 | |
| 0048469 | |
| 0007166 | |
| 0006874 | |
| 0002062 | |
| 0007204 | |
| 0008285 | |
| 0001503 | |
| 0002076 | |
| 0008284 | |
| 0007165 | |
| 0016323 | |
| 0031526 | |
| 0016021 | |
| 0005622 | |
| 0016020 | |
| 0007568 |
| Rat chromosome position | 8q32 |
|---|
| Swiss-Prot Accession | Q03431 |
|---|---|
| Q0VGD7 | |
| Q71UK6 | |
| Q8NHB4 | |
| Q80WU8 | |
| P41593 | |
| Q91WV4 | |
| P25961 | |
| Q76N28 | |
| Q2M1U3 |
| PIR ID | I54195 |
|---|---|
| I38139 |
| Unigene ID | Hs.1019 |
|---|---|
| Mm.3542 | |
| Rn.48025 |
| KEGG ID | hsa:5745 |
|---|---|
| mmu:19228 | |
| rno:56813 |
| Swiss-Prot ID | PTH1R_RAT |
|---|---|
| PTH1R_HUMAN | |
| Q80WU8_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00194506 |
|---|---|
| IPI00010732 | |
| IPI00330662 | |
| IPI00169244 | |
| IPI00791285 | |
| IPI00114634 |
| Homologene ID | 267 |
|---|
| RGD ID | 3442 |
|---|
| MGI ID | 97801 |
|---|